Fine needle aspiration cytology of pulmonary, well‐differentiated fetal adenocarcinoma prepared by the ThinPrep<sup>®</sup> method

Kneafsey, Paul; Duggan, Máire A.; McFadden, Sean

doi:10.1046/j.1365-2303.2003.00031.x

Cited by 10 publications

(14 citation statements)

References 8 publications

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“…9,18-21 Additionally, there has been noted, in some studies, a focal tigroid background commonly identified at the edge of cellular aggregates. 9,[18][19][20][21] The findings in this case were in agreement with previous reports with respect to the identification of two distinct populations of cells in the presence of abundant stroma. These similar findings can also be suggestive of hamartoma or pleomorphic adenoma, however, this case, did not have the typical epithelial morphology of these latter two diagnoses.…”

Section: Discussionsupporting

confidence: 92%

“…The cytomorphologic features of WDFA have been reported in a limited number of reports and have shown the presence of a dual population of cells: (1) small cells, uniform in appearance with inconspicuous nucleoli, prominent subnuclear vacuoles and less often supranuclear vacuoles that show an acinar and glandular architecture and (2) larger squamoid cells with prominent nucleoli, dense cytoplasm with morule formation . Additionally, there has been noted, in some studies, a focal tigroid background commonly identified at the edge of cellular aggregates …”

Section: Discussionmentioning

confidence: 98%

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Well‐differentiated fetal adenocarcinoma of the lung mimicking adenoid cystic carcinoma on fine needle aspiration: A case report

Rerkpichaisuth

Collins

Boonyaarunnate

et al. 2016

Diagnostic Cytopathology

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Well-differentiated fetal adenocarcinoma (WDFA) of the lung is a rare variant of adenocarcinoma with an unusual morphology. Although the histologic features of this rare neoplasm have been well established, there is a deficit in the literature with regards to its discrete cytomorphologic features. We report the fine needle aspiration (FNA) findings of a case of this unusual malignancy in a 44-year-old man with an incidental lung nodule. FNA revealed three-dimensional clusters of epithelial cells with scant cytoplasm, hyperchromatic nuclei that are associated with an extracellular metachromatic matrix. The original cytology report was signed out as an epithelial neoplasm favor adenoid cystic carcinoma. Consequently, a wedge resection of the lung was done and the histologic diagnosis was WDFA of the lung. The findings of minimal nuclear atypia in association with focally abundant spheres of extracellular matrix can mimic adenoid cystic carcinoma. WDFA has good prognosis and therefore, pre-operative cytologic diagnosis is critical to clinical management. We present the cytomorphologic features of this neoplasm with particular emphasis on a potential diagnostic pitfall of this rare entity. Diagn. Cytopathol. 2016;44:917-920. © 2016 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Well‐differentiated fetal adenocarcinoma of the lung mimicking adenoid cystic carcinoma on fine needle aspiration: A case report

Rerkpichaisuth

Collins

Boonyaarunnate

et al. 2016

Diagnostic Cytopathology

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“…[2][3][4] However, in no reported case the aspirated tumor cells showed similar cytologic features with the ones present in the bronchial brush of our patient. Our case of pulmonary WFA was apparently the first reported example of this neoplasm with correct cytologic diagnosis by bronchial brush and immunocytochemistry.…”

Section: Dear Dr Bedrossianmentioning

confidence: 53%

Pulmonary well-differentiated fetal adenocarcinoma diagnosed by bronchial brush and immunocytochemistry

Odashiro¹,

Nguyen

2006

Diagn. Cytopathol.

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A 41-yr-old man with a long history of cigarette smoking presented to his family physician with an intermittent cough of 4-wk duration. Physical examination revealed no remarkable findings. A chest roentgenogram showed a 3-cm mass lesion located near the hilum of his right lung. A chest CT-scan confirmed the lesion to be a well-demarcated and solid tumor located in the lobar bronchus of the right middle lobe. No hilar lymphadenopathy was identified. The patient underwent a bronchoscopy, and a tumor involving the lobar bronchus of the right middle lobe was visualized. A cell sample was obtained by bronchial wash, and the bronchial lesion was brushed two times. Four direct smears prepared from two bronchial brushes and four cytospin smears prepared from the bronchial wash were fixed in 95% ethanol and stained with Papanicolaou method. Two tumor tissue fragments measuring 3 mm in greatest dimension obtained by biopsy were fixed in formalin and processed for routine histologic examination.The bronchial wash was negative for malignant cells. The four smears prepared from two bronchial brushes were cellular and revealed irregular, monolayered sheets of malignant epithelial cells showing clear, ill-defined cytoplasm, slightly pleomorphic, round or oval nuclei and inconspicuous nucleoli. In a few tumor cell groups nuclear crowding and overlapping were noted. The cytologic findings were in keeping with an adenocarcinoma with clear cell change (Fig. 1). However, a pulmonary welldifferentiated fetal adenocarcinoma (WFA) was not ruled out with certainty.Two Papanicolaou-stained smears containing tumor cells were stained with periodic acid-Schiff (PAS) and with PAS with prior diastase digestion (PASD). The tumor cell cytoplasm reacted positively with PAS and negatively with PASD, indicating a nonmucus secreting adenocarcinoma that was rich in glycogen contents. One Papanicolaou-stained smear was stained with commercial chromogranin antibody by the avidin-biotin-complex (ABC) technique without prior destaining. The tumor cells that were present reacted positively with this antibody. The cytologic, cytochemical, and immunocytochemical features of the patient's tumor were in keeping with a pulmonary WFA. The two biopsied tumor tissue fragments showed severe crushing artifacts and were nondiagnostic.The patient's lung tumor was subsequently removed by right pneumonectomy. The resected right lung showed a round, solid malignant tumor arising from the middle lobe lobar bronchus with minimal invasion into the surrounding lung parenchyma. Several tumor tissue blocks were fixed in formalin and processed for histologic, histochemical, and immunohistochemical studies. Histologically, the lung tumor consisted of branching tubules lined by a single layer of columnar epithelial cells with clear cytoplasm, basally located, oval, slightly pleomorphic, hyperchromatic nuclei and inconspicuous nucleoli (Fig. 2). In most tumor cells a large supranuclear cytoplasmic clear vacuole was present. The stroma contained capillary blood vessels and scatt...

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“…The more worrying symptoms are haemoptysis and chest pain [2,3,7,13,[15][16][17]. One of the rare causes of chest pain is the presence of fluid in the pleural cavity caused by its involvement with cancer, or secondary lesions connected with emboli in the pulmonary vessels accompanying the adenocarcinoma [15,18]. The patient, whose case is discussed here, reported mainly a cough and chest pain.…”

Section: Discussionmentioning

confidence: 99%

Fetal adenocarcinoma — a rare variant of lung adenocarcinoma with good prognosis

Winek¹,

Caban²,

Zych³

et al. 2017

Nowotwory. Journal of Oncology

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Fetal adenocarcinoma (FA) is a rare variant of lung adenocarcinoma with a good prognosis which represents approximately 0.5% of all primary lung neoplasms. The tumour has nonciliated tubules with morules in the lumen resembling fetal lung at 10 to 16 weeks of gestation. FA typically occurs in young patients 75-80% of whom are tobacco smokers. FA occurs in low-and high-grade forms. Surgical procedure is usually necessary to obtain final diagnosis and a complete surgical resection is the standard treatment. The 5-year survival rate for FA is about 75-80%. We report a case of 32-year-old male, a smoker, who had an incomplete regression of parenchymal consolidations after antibiotic treatment, which led to further diagnostics. An intravenous tumour in one of the pulmonary veins with concomitant development of collateral circulation and pulmonary venous infarction were additional diagnostic problems. Based on the intraoperative microscopic examination, fetal adenocarcinoma was diagnosed. An upper right bilobectomy with intrapericardial ligation of the right superior pulmonary vein was performed as radical treatment. At the 9-month follow-up stage, there has been no evidence of disease recurrence. NOWOTWORY J Oncol 2016; 66, 5: 381-385

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Fine needle aspiration cytology of pulmonary, well‐differentiated fetal adenocarcinoma prepared by the ThinPrep^® method

Cited by 10 publications

References 8 publications

Well‐differentiated fetal adenocarcinoma of the lung mimicking adenoid cystic carcinoma on fine needle aspiration: A case report

Well‐differentiated fetal adenocarcinoma of the lung mimicking adenoid cystic carcinoma on fine needle aspiration: A case report

Pulmonary well-differentiated fetal adenocarcinoma diagnosed by bronchial brush and immunocytochemistry

Fetal adenocarcinoma — a rare variant of lung adenocarcinoma with good prognosis

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Fine needle aspiration cytology of pulmonary, well‐differentiated fetal adenocarcinoma prepared by the ThinPrep® method

Cited by 10 publications

References 8 publications

Well‐differentiated fetal adenocarcinoma of the lung mimicking adenoid cystic carcinoma on fine needle aspiration: A case report

Well‐differentiated fetal adenocarcinoma of the lung mimicking adenoid cystic carcinoma on fine needle aspiration: A case report

Pulmonary well-differentiated fetal adenocarcinoma diagnosed by bronchial brush and immunocytochemistry

Fetal adenocarcinoma — a rare variant of lung adenocarcinoma with good prognosis

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Fine needle aspiration cytology of pulmonary, well‐differentiated fetal adenocarcinoma prepared by the ThinPrep^® method