Fine needle aspiration cytology of metastatic polymorphous low‐grade adenocarcinoma of the palate in a cervical lymph node

Kawahara, Akihiko; Harada, Hiroshi; Abe, Hideyuki; Yamaguchi, Tomohiko; Taira, Tomoki; Mihashi, Hiroyuki; Naito, Yoshiki; Akiba, Jun; Kage, Masayoshi

doi:10.1111/j.1365-2303.2011.00921.x

Cited by 6 publications

(14 citation statements)

References 6 publications

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“…We found a total of 12 articles describing findings from a total of 44 patients. [7][8][9][10][11][12][13][14][15][16][17]19 Main features are summarized in Tables 2 and 3…”

Section: Review Of the Cytologic Literaturementioning

confidence: 99%

“…Reflecting the rarity of the tumor and peculiar locations, the cytologic experience is still limited with few reported series. [7][8][9][10][11][12][13][14][15][16][17] The recent discovery of a specific mutation in PAC (E710D in PRKD1 gene) is of considerable diagnostic interest. 18 In contrast to PAC, most cribriform adenocarcinomas of minor salivary glands (CAMSGs) show rearrangements rather than mutations in PRKD genes (PRKD1-3), including ARID1A-PRKD1 and DDX3X-PRKD1 gene fusions.…”

Section: Introductionmentioning

confidence: 99%

“…The histologic diagnosis of PAC can be very difficult in small biopsies 6 or in fine needle aspiration (FNA) cytology samples. Reflecting the rarity of the tumor and peculiar locations, the cytologic experience is still limited with few reported series 7‐17 . The recent discovery of a specific mutation in PAC (E710D in PRKD1 gene) is of considerable diagnostic interest 18 .…”

Section: Introductionmentioning

confidence: 99%

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Fine needle aspiration cytology of polymorphous adenocarcinoma of the salivary glands: A report of 11 patients and review of the literature

Jiménez‐Heffernan

Rodríguez-García

González‐Peramato

et al. 2020

Diagnostic Cytopathology

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Background: Polymorphous adenocarcinoma (PAC) is a rare malignant tumor of the minor salivary glands. It has an infiltrative growth, variable architectural patterns, neurotropism and cellular monomorphism. Approximately 75% of the cases show a specific mutation in the protein kinase D1 (PRKD1) gene. Reflecting the rarity of the tumor and intraoral location, the cytologic experience is limited with few reported series. In this study we analyze our cytologic experience to determine if a preoperative diagnosis is possible. Methods: A retrospective study of 11 patients with PAC in which a cytologic study was available. A review of the literature was also performed. Results: Our study shows that PAC has relatively constant cytological features. The analysis of the cytological literature although it shows some heterogeneity, also reveals repetitive cytological findings. Smears are cellular with irregular groups some showing pseudopapillary branching morphology. Monolayered clusters and small acinar structures are also present. Most cases have small metachromatic globules embedded within the groups determining a cylindromatous pattern. Tumoral cells are small and uniform with scarce to moderate cytoplasm. Nuclei are round and oval with occasional grooves and small nucleoli. Conclusion: PAC has characteristic cytological features that together with its location in minor salivary gland must make us consider it preoperatively. It may resemble basal cell adenoma and epithelial-rich pleomorphic adenoma so we should be cautious in the final diagnosis. Whenever possible, the characteristic cytomorphology of PCA should make us evaluate the mutational status of PRKD1 gene since it may permit a more accurate diagnosis.

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“…We found a total of 12 articles describing findings from a total of 44 patients. [7][8][9][10][11][12][13][14][15][16][17]19 Main features are summarized in Tables 2 and 3…”

Section: Review Of the Cytologic Literaturementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fine needle aspiration cytology of polymorphous adenocarcinoma of the salivary glands: A report of 11 patients and review of the literature

Jiménez‐Heffernan

Rodríguez-García

González‐Peramato

et al. 2020

Diagnostic Cytopathology

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“…These globoid structures were so obvious in two of our cases that a mistaken diagnosis of AdCC was issued. Hyaline spherules/globules are commonly mentioned as features in nearly all prior cytologic reports of PAC 7‐11,14,17,19,22 . In fact, from the review of Jiménez‐Heffernan et al, 9 AdCC was the most common diagnosis incorrectly rendered.…”

Section: Discussionmentioning

confidence: 99%

“…PAC has a predilection to affect minor SG sites of the oral cavity such as the hard and soft palate, buccal mucosa, base of tongue, and lip—sites where diagnostic FNA biopsy is not typically employed in most medical centres. To our knowledge, merely five cytologic series of PAC having greater than five patients have been published in the English literature 7‐11 with the rest consisting of single or dual case reports 12‐19 …”

Section: Introductionmentioning

confidence: 99%

Classic polymorphous adenocarcinoma: Fine needle aspiration cytopathology of eight cases

Wakely

Lott-Limbach

2021

Cytopathology

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Introduction The cytopathology and diagnostic accuracy of salivary gland (SG) polymorphous adenocarcinoma (PAC) is the subject of a limited number of reports. We undertook a review of our experience with fine needle aspiration (FNA) biopsy and PAC. Materials and methods A search was made of our cytopathology files for PAC cases that also had histopathological confirmation. FNA biopsy smears and cell‐blocks were performed and examined using standard techniques. Results Eight FNA biopsy cases of histologically proven PAC from 7 patients [F:M = 1.3:1, age 39‐75 years, mean = 58] met study inclusion. Metastatic aspirates were most common (4), followed by 3 primary cases and 1 locally recurrent neoplasm. Primary FNA sites included hard palate (1 case), lip (1), and lateral tongue (1); all metastatic sites were in the neck. A precise cytologic diagnosis was made in 38% of cases; however, when applying the Milan classification system, 100% could be categorised as either malignant or of uncertain malignant potential. Ancillary immunohistochemical testing performed in 44% of the cases was non‐specific. Cytologic smears showed cellular uniformity and structural variety of cell groups with tubular, branching, cribriform, and convex patterns as well as variable, but occasionally abundant globular myxoid stroma leading to confusion with adenoid cystic carcinoma. Conclusion The imitative cytopathology of PAC with other SG neoplasms as well as its infrequency in routine FNA biopsy practice makes specific interpretation difficult, but using a classification system allows for appropriate patient management. Molecular testing in future specimens holds promise for enhancing diagnostic accuracy.

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Cytology of low‐grade cribriform cystadenocarcinoma in salivary glands: Cytological and immunohistochemical distinctions from other salivary gland neoplasms

Ohta

Hirota

Kohno

et al. 2015

Diagnostic Cytopathology

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Low-grade cribriform cystadenocarcinoma of the parotid gland is rare malignancy that is classified as a variant of cystadenocarcinoma. In routine cytologic slides from fine-needle aspiration of a parotid gland, we found several pseudopapillary clusters comprising mucus-producing cells. They included a few tumor cells having three-dimensional nuclear atypia and slight hyperchromatism, although most of the tumor cells showed bland nuclei. Our initial cytological diagnosis was: "Indeterminate. Uncertain whether cystadenocarcinoma or cystadenoma." The subsequent histological diagnosis was low-grade cribriform cystadenocarcinoma. Immunohistochemical staining showed diffuse and strong reactivity for S-100; tumor nests that were rimmed by p63(+) cells, which suggests intraductal proliferation. Here, we report cytomorphological findings of this case, and discuss cytological and immunohistochemical distinctions between low-grade cribriform cystadenocarcinoma and other salivary gland tumors, including a review of the literature.

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Fine needle aspiration cytology of metastatic polymorphous low‐grade adenocarcinoma of the palate in a cervical lymph node

Cited by 6 publications

References 6 publications

Fine needle aspiration cytology of polymorphous adenocarcinoma of the salivary glands: A report of 11 patients and review of the literature

Fine needle aspiration cytology of polymorphous adenocarcinoma of the salivary glands: A report of 11 patients and review of the literature

Classic polymorphous adenocarcinoma: Fine needle aspiration cytopathology of eight cases

Cytology of low‐grade cribriform cystadenocarcinoma in salivary glands: Cytological and immunohistochemical distinctions from other salivary gland neoplasms

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