Fine needle aspiration cytology of cystic primary adult granulosa cell tumor of the ovary: Potential diagnostic pitfalls with other cystic ovarian lesions

Abstract

FNA of CAGCT of ovary can be a challenging diagnosis as classic cytologic features may not be present and can be confused with benign follicular cyst especially when the ultrasound study favor benign cystic lesion. Rarely this tumor may show prominent papillary component and can be confused for a more clinically aggressive tumor such as papillary serous carcinoma. Diagn. Cytopathol. 2016;44:461-465. © 2016 Wiley Periodicals, Inc.

Cytologic features of needle aspiration of ovarian sex cord tumor with annular tubules: Report of two cases and literature review

“…Cytologically, granulosa cell tumors often show poorly formed Call‐Exner body‐like rosettes composed of round‐to‐oval tumor cells with granular cytoplasm and nuclear grooves . The Call‐Exner bodies do not appear three‐dimensional and are less cellular than the rosette‐like structures in SCTAT . Although both tumors demonstrate a rosette pattern, the characteristic antipodal nuclear arrangement and abundant hyaline cores characteristic of SCTAT are not seen in granular cell tumors.…”

Cytologic features of sex cord‐stromal tumors in women

“…Although cytologic features of SCSTs have been previously described in the literature, they are limited to small case series and/or case reports 5,18‐21 . Among the few reported studies, only 1 cytological preparation (ie, fine‐needle biopsy; FNB) was used to describe the morphology 6,9,22 . In this study, we describe the cytomorphologic features, in a variety of sample types, of a large cohort of AGCTs and compare them to those seen in other types of SCST.…”

“…AGCTs constitute 2% of all ovarian malignancies 4‐6 and 85% of malignant SCSTs 7 . They occur primarily in perimenopausal women, with a peak between 50 and 55 years of age, 8,9 but can occur in any age group. AGCTs usually present with abdominal pain and abnormal uterine bleeding.…”