Intraoperative Cytological Diagnosis of Ovarian Cancer

Rady, Helmy A.; Mohammed, Noha; Farag, Mohammed M.

doi:10.1007/s40944-019-0297-y

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…Serous carcinomas have been reported as the most common type of malignant tumors in previous studies from Pakistan, India, and Bangladesh; however, all these studies have reported mucinous carcinoma to be the second common cancer, in contrast to endometrioid carcinoma in our study. [8][9][10] Globally, ovarian cancer has a high incidence in European descent, and Serous carcinoma is the most common malignant ovarian tumor in Europe and the USA. In contrast, Japan, Thailand, and Singapore report a high percentage of Endometrioid, Mucinous, and Clear cell carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Significance of peritoneal washing cytology in the accurate staging of malignant ovarian tumors

et al. 2021

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Objectives: To identify the percentage of ovarian cancers with positive peritoneal cytology and to correlate the positive cytology with the prognostic factors. Methods: This retrospective, cross-sectional study, evaluated the data of surgical specimens of malignant ovarian tumors, received in the Department of Pathology, Dow University of Health Sciences over a period of three years. The peritoneal cytology was correlated with these prognostic parameters: the size of the tumor, stage, capsular invasion, omental, and lymph node metastasis. Results: Eighty malignant ovarian tumors were diagnosed. Serous carcinoma was the most common ovarian tumor, diagnosed in 24 (30.0%) cases, followed by endometrioid carcinoma in 17 (21.25%) and Granulosa cell tumor in 11 (13.75%) cases. The mean age of the patients was 41.91 years (range 7-71 years). The mean size of the tumors was 10.03 cm (SD 5.62 cm). The ovarian capsular invasion was present in 27 (33.75%) tumors. Peritoneal cytology was positive in 10/24 cases, with a detection rate of 41.66%. Omentum was involved in 12/34 (35.29%) cases. Lymph node dissection was performed in three cases, two were reported as positive for metastasis. Peritoneal cytology significantly correlated with the tumor size (p=0.045), and with ovarian capsular invasion (p=0.054) and omental metastasis (p=0.052). Most of the tumors were staged as FIGO stage IA. Conclusion: Peritoneal cytology correlates with the tumor size, stage, and omental metastasis of the malignant ovarian tumors. It should be routinely performed at the time of surgery for the optimal staging of the patients. doi: https://doi.org/10.12669/pjms.38.1.4393 How to cite this:Gulzar R, Shahid R, Mumtaz S, Hassan JA. Significance of peritoneal washing cytology in the accurate staging of malignant ovarian tumors. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4393 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Significance of peritoneal washing cytology in the accurate staging of malignant ovarian tumors

et al. 2021

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“…Older literature has shown lower technical success of TVUS‐FNAB compared to TVUS‐CNB; however, most of these analyses were published in the 1990s 8,21–23 . Several studies have also previously reported favorable rates of diagnostic accuracy of transabdominal or intraoperative FNAB although these differ by technique 24–32 …”

Section: Discussionmentioning

confidence: 99%

“…8,[21][22][23] Several studies have also previously reported favorable rates of diagnostic accuracy of transabdominal or intraoperative FNAB although these differ by technique. [24][25][26][27][28][29][30][31][32] This retrospective study assessing TVUS-FNAB for pelvic masses found an overall relatively high adequacy rate of 85%. Although this is slightly lower than reported adequacy of core biopsy (as high as 96%), 33 the addition of a core biopsy in select cases when preliminary cytopathology review lacked diagnostic confidence provided a diagnosis in the remaining patients (4/17; 24%) for whom CNB was performed.…”

Section: Discussionmentioning

confidence: 99%

Transvaginal Ultrasound‐Guided Fine‐Needle Aspiration Biopsy of Pelvic Lesions

Penna

Pōder

Jha

et al. 2021

J of Ultrasound Medicine

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Objectives To assess adequacy of transvaginal ultrasound‐guided fine‐needle aspiration biopsy (TVUS‐FNAB) for pathologic diagnosis of pelvic masses performed using onsite cytopathology consultation. Methods In this Institutional Review Board approved, Health Insurance Portability and Accountability Act (HIPAA) compliant study, radiology records were retrospectively queried to identify patients who underwent TVUS‐FNAB of a pelvic mass over a 11‐year duration. TVUS‐FNAB adequacy was determined by correlating cytopathology results with transvaginal ultrasound‐guided core‐needle biopsy (TVUS‐CNB) or surgical pathology results when available, and with clinical diagnostic confidence when additional pathology confirmation was not available. Secondary analysis included patient age, history of hysterectomy, or pelvic malignancy. Target‐specific features analyzed included mass size, depth, location, and final pathologic diagnosis. Results Sixty patients underwent TVUS‐FNAB of pelvic masses, 43 of which underwent FNAB only and 17 underwent both TVUS‐FNAB and TVUS‐CNB during the same procedure. TVUS‐FNAB alone was adequate for diagnosis in 51 (85%) cases and addition of core‐needle biopsy (CNB) achieved a diagnosis in additional 4 patients, increasing overall diagnostic accuracy to 92% (55/60). FNAB inadequacy had statistically significant association with increasing mass depth, occurrence of a minor intraprocedural complication, and decision to perform a CNB (P <.05). Number of FNAB passes, mass size, history of hysterectomy, and final diagnosis were not statistically significant predictors of FNAB adequacy. Conclusion TVUS‐FNAB has a high specimen adequacy rate when performed with an onsite cytopathologist and can be considered first‐line approach for image‐guided sampling of pelvic lesions with option to add CNB if preliminary cytopathologic review does not confirm sample adequacy.

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Intraoperative Diagnosis: Imprint Cytology and Frozen Section in Ovarian Tumor, Averting Additional Surgery

Lanjewar,

Deotale,

Vagha

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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A granulosa cell tumor (GCT) is a type of ovarian cancer that constitutes approximately 10% of all ovarian malignancies. In this case, a female patient with hypothyroidism and a history of irregular periods was diagnosed with polycystic ovarian disease (PCOD) after a radiological examination, which subsequently recommended surgery. Frozen section analysis and imprint cytology assisted in the intraoperative diagnosis of the tumor. These diagnostic tools helped adopt a minimally invasive surgery where only the affected ovary was removed, thus avoiding an extra surgical procedure. It is usually described as a low-grade cancer, but it can recur many years later. Therefore, repeated imaging and tumor markers should be used to monitor the patient after the treatment and ensure early detection of the relapse, thus improving the patient’s prognosis.

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Intraoperative Cytological Diagnosis of Ovarian Cancer

Cited by 3 publications

References 24 publications

Significance of peritoneal washing cytology in the accurate staging of malignant ovarian tumors

Significance of peritoneal washing cytology in the accurate staging of malignant ovarian tumors

Transvaginal Ultrasound‐Guided Fine‐Needle Aspiration Biopsy of Pelvic Lesions

Intraoperative Diagnosis: Imprint Cytology and Frozen Section in Ovarian Tumor, Averting Additional Surgery

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