Significance of peritoneal washing cytology in the accurate staging of malignant ovarian tumors

Gulzar, Rubina; Shahid, Rabia; Mumtaz, Shazia; Hasan, Jahan Ara

doi:10.12669/pjms.38.1.4393

Cited by 5 publications

(7 citation statements)

References 17 publications

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“…The absence of peritoneal cytology with the surgical specimen results in an incomplete staging of the ovarian cancers. The prognostic significance of malignant cells in washings or brushings varies, depending on the primary ovarian lesion, for example in serous borderline tumour or serous papillary carcinoma 20,21 . Moreover, positive washing cytology may be associated with adnexal involvement of endometrial carcinoma 22 .…”

Section: Discussionmentioning

confidence: 99%

“…The prognostic significance of malignant cells in washings or brushings varies, depending on the primary ovarian lesion, for example in serous borderline tumour or serous papillary carcinoma. 20,21 Moreover, positive washing cytology may be associated with adnexal involvement of endometrial carcinoma. 22 The significance of positive washings remains controversial for most types of uterine carcinoma, and staging for prognosis now requires histological confirmation of serosal/adnexal involvement.…”

Section: Tis Effusion Diagnostic Categoriesmentioning

confidence: 99%

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Categorisation of peritoneal serous effusions using the International System for Reporting Serous Fluid Cytopathology—A study on gynaecological samples

et al. 2023

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Background Cytology of serous effusions is an indispensable diagnostic tool for the diagnosis of non‐neoplastic as well as neoplastic effusions, aiding in the categorisation, staging, and prognostication of the patient. This study focuses on reclassifying cases of peritoneal fluid cytology following the International System for Reporting Serous Fluid Cytopathology (TIS), highlighting various challenges encountered and adding to the body of data regarding the risk of malignancy (ROM), focussing on peritoneal effusions due to gynaecological causes. Methods Peritoneal effusion samples were retrieved from our department's archives and reclassified according to the TIS. The ROM for each category was calculated based on available surgical follow‐up. Results A total of 818 peritoneal effusions were studied. Following the definitions and guidelines of the TIS, the cases were reclassified with 125 (15.2%) in the category of non‐diagnostic (ND), 595 (72.7%) as negative for malignancy (NFM), 26 (3.2%) as atypia of undetermined significance (AUS), 12 (1.5%) as suspicious for malignancy (SFM), and 60 (7.3%) as malignant (MAL). The respective ROM values for each category were 16.9%, 12.1%, 50%, 80%, and 100%, respectively. By considering the MAL and SFM groups as positive, and the ND, NFM, and AUS groups as negative, the diagnostic accuracy, sensitivity, specificity, and positive and negative predictive values were determined as 85.2%, 36.7%, 99.1%, 91.7%, and 84.5%, respectively. Conclusions Peritoneal cytology categorisation following the proposed TIS offered a practical approach for categorisation of the fluids received. The ROMs reported in our study were mostly concordant with those published according to the TIS.

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Section: Discussionmentioning

confidence: 99%

Section: Tis Effusion Diagnostic Categoriesmentioning

confidence: 99%

Categorisation of peritoneal serous effusions using the International System for Reporting Serous Fluid Cytopathology—A study on gynaecological samples

et al. 2023

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“…Various studies have been conducted to determine the detection rate of peritoneal spread by peritoneal cytology that varied with various studies. Gulzar et al reported a cytology detection rate of 41.6%, Ozkara et al reported a rate of 62.2%, and Sanches and Matsubara reported a rate of 20% [ 21 - 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…A study was conducted in Pakistan by Gulzar et al on the significance of PWC for accurate staging of OCs. They found positive peritoneal cytology to be correlated to tumor stage [ 21 ]. A study was conducted by Yoshimura et al, in which 90 patients with OCs were examined.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Parameters Associated With Peritoneal Involvement in Epithelial Ovarian Tumors

Hashmi¹,

Rashid²,

Asif³

et al. 2023

Cureus

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IntroductionOvarian tumors remain one of the leading malignancies of the female genital tract, with a high mortality rate due to their insidious onset and lack of detection at an earlier stage. These tumors metastasize by direct extension into the neighboring pelvic organs; hence, the detection of peritoneal metastasis is valuable for staging and prognostic purposes. Peritoneal wash cytological analysis is an effective predictor of the involvement of the ovarian surface and peritoneal dissemination even in subclinical involvement of the peritoneum. The study aims to determine the significance of peritoneal wash cytology as a prognostic parameter and correlate it with various clinicohistological features.

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“…Although full inspection of peritoneal cavity could not be achieved in three (9%) patients, peritoneal lavage could be performed in all patients. Peritoneal cytology (CY) has been used widely in the diagnosis and staging of various cancers, such as ovarian, and gastric cancer (15)(16)(17). Positive peritoneal cytology (CY+) in patients with PC is equivalent to metastatic disease and Stage IV according to the American Joint Committee on Cancer and the NCCN (18,19).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Staging Laparoscopy in Patients With Pancreatic Cancer: A Single Center Prospective Cohort Study

SHINDO,

TOKUMITSU,

MATSUI

et al. 2023

In Vivo

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Background/Aim: Staging laparoscopy (SL) for pancreatic cancer (PC) is considered useful to improve accuracy of staging and resectability. However, given the current accuracy of preoperative imaging, the routine application of SL remains unclear. Therefore, we aimed to investigate the importance of SL in patients with PC without radiological distant metastasis. Patients and Methods: This was a prospective, cohort, observational study. SL was performed in all patients with PC without radiological distant metastasis before pancreatectomy or chemotherapy at the Yamaguchi University Hospital. Results: Between July 2020 and March 2023, 55 patients underwent SL with peritoneal cytology. The median age was 71, with 53% male patients. SL revealed occult metastasis in six (11%) patients including positive peritoneal cytology (n=6), and peritoneal dissemination (n=1). The resectability of unresectable locally advanced (UR-LA) was associated with a significantly increased risk of occult metastasis (p=0.0211). The median operative time was 40 min, and the median volume of blood loss was 3 ml. There were no severe complications (Clavien-Dindo III or higher). Conclusion: SL with peritoneal cytology regardless of previous abdominal surgery is safe and effective to determine accurate staging. Therefore, SL with peritoneal cytology should be considered for patients with PC without radiological distant metastasis, especially in those with UR-LA. Patients and MethodsPatients. This study was a single-center prospective cohort study including patients with PC without distant metastasis at the Yamaguchi University Hospital (Ube, Japan) (UMIN000043376). All 55 patients had pathological evidence of PC before or during 2704

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Significance of peritoneal washing cytology in the accurate staging of malignant ovarian tumors

Cited by 5 publications

References 17 publications

Categorisation of peritoneal serous effusions using the International System for Reporting Serous Fluid Cytopathology—A study on gynaecological samples

Categorisation of peritoneal serous effusions using the International System for Reporting Serous Fluid Cytopathology—A study on gynaecological samples

Clinicopathological Parameters Associated With Peritoneal Involvement in Epithelial Ovarian Tumors

Efficacy of Staging Laparoscopy in Patients With Pancreatic Cancer: A Single Center Prospective Cohort Study

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