Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Leon, Marino E.; Deschler, Daniel G.; Wu, Sijian; Galindo, Lorenzo M.

doi:10.1159/000326740

Cited by 13 publications

(12 citation statements)

References 48 publications

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“…Beside dissociated cells, the background contained abundant myxoid extracellular material and naked oval nuclei. [2][3][4][5][6][7][8] Thin branching capillaries were observed in most of the tissue fragments. On the other hand, some differences were also observed between cases on record.…”

Section: Discussionmentioning

confidence: 99%

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Cytological features of lipoblastoma: A report of three cases

Kloboves-Prevodnik

Us‐Krašovec

Gale³

et al. 2005

Diagnostic Cytopathology

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Lipoblastoma is a rare benign neoplasm occurring mostly in children under the age of three. Accurate preoperative diagnosis is mandatory for planning the treatment. The main aim of this study is to establish the cytological features of lipoblastoma and to answer the question: "Is cytological diagnosis of lipoblastoma reliable?"Preoperative fine-needle aspiration biopsy (FNAB) and tissue sections of three children treated for lipoblastoma at the Division of Pediatrics, University Medical Center, Ljubljana, Slovenia, in the period from 1997 to 2004 were reexamined. The Giemsa- and Papanicolaou-stained FNAB smears were moderately or poorly cellular and contained lipocytes, lipoblasts, and spindle cells in various proportions. The tumor cells were in clusters and tissue fragments or as single cells. Thin branching capillaries were observed in most of the clusters and tissue fragments. In the background, abundant myxoid extracellular material and naked oval nuclei were present. In the first case, the cytological diagnosis was benign soft-tissue tumor, in the second the diagnosis was not conclusive and the last case was correctly diagnosed as lipoblastoma. In the differential diagnosis of the second case, both lipoblastoma and liposarcoma were considered cytologically as well as histologically. At 7-yr follow-up, there is no evidence of the disease.Thus, we conclude that lipoblastoma with typical cytological features could be accurately diagnosed by FNAB. However, tumors containing numerous lipoblasts could pose a diagnostic problem.

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Section: Discussionmentioning

confidence: 99%

“…Only a few sporadic reports of this tumor have appeared in cytological literature. [2][3][4][5][6][7][8] However, fine-needle aspiration biopsy (FNAB) offers quick, nontraumatic evaluation of tumors and tumor-like conditions in children. Supported by ancillary studies FNAB could give an accurate preoperative diagnosis.…”

mentioning

confidence: 99%

Cytological features of lipoblastoma: A report of three cases

Kloboves-Prevodnik

Us‐Krašovec

Gale³

et al. 2005

Diagnostic Cytopathology

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“…All of the previous reports and our own observations consistently describe the typical cytological characteristics of lipoblastoma as a mixed population of lipoblasts and mature adipocytes immersed in a myxoid background with a rich network of capillary vessels, surrounded by spindle cells and naked nuclei, mostly with no cytological atypia. [3][4][5][6][7][8][9][10][11] Although these features allow a correct and straightforward diagnosis by way of FNA in the appropriate clinical setting, problems arise when dealing with lesions in unusual locations, especially in the adolescent or adult age group.…”

Section: Discussionmentioning

confidence: 99%

“…There are only a few published case reports and small case series on the diagnosis of these lesions by fine-needle aspiration (FNA) cytology. [3][4][5][6][7][8][9][10][11] Although the clinical diagnosis can be straightforward in the appropriate setting, problems arise when dealing with lesions in unusual locations, especially in adolescent patients. [12][13][14] In about 70% of cases, patients harbor the PLAG1 (Pleomorphic Adenoma Gene 1) gene rearrangement, which can be found easily using fluorescent in situ hybridization (FISH).…”

Section: Introductionmentioning

confidence: 99%

Fine‐needle aspiration of lipoblastoma: Cytological, molecular, and clinical features

Ferreira¹,

Esteves²,

Fonseca³

et al. 2017

Cancer Cytopathology

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“…Lipoblastomas mainly arise in extremities and trunk and rarely in head and neck; only 3 cases of lipoblastomas in the parotid region have been described. The prognosis is good, with a low recurrence rate after complete surgical excision [20,21] .…”

Section: Discussionmentioning

confidence: 99%

Lipoma of the Deep Lobe of the Parotid Gland: Report of 3 Cases

Gooskens

Manni

2006

ORL

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Since lipomas are common soft-tissue neoplasms in other regions of the body, they are found only rarely in the parotid gland and are, therefore, often not considered in the initial differential diagnosis of parotid gland tumours. Even rarer are lipomas arising in the deep lobe of the parotid gland with only 6 cases presented in the literature. Lipomas originating in the parapharyngeal space are also extremely rare. When there is any suspicion, computed tomography and especially magnetic resonance imaging are of high diagnostic value. Fine-needle aspiration cytology seems not to contribute much to an accurate diagnosis. None of these preoperative examinations allows an absolute reliable distinction between a lipoma and a liposarcoma. The preferred treatment is complete surgical excision which will minimize the possibility of a recurrence and will also lead to a definitive diagnosis. We report 3 patients with a lipoma of the deep lobe of the parotid gland, extending into the parapharyngeal space, and discuss differential diagnosis and radiological features of lipomas in this rare location.

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Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Cited by 13 publications

References 48 publications

Cytological features of lipoblastoma: A report of three cases

Cytological features of lipoblastoma: A report of three cases

Fine‐needle aspiration of lipoblastoma: Cytological, molecular, and clinical features

Lipoma of the Deep Lobe of the Parotid Gland: Report of 3 Cases

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