Fine-needle aspiration findings in patients with polymorphous low grade adenocarcinoma of the salivary glands

Cytology of salivary duct carcinoma

“…Besides pleomor- phic adenoma, polymorphous low-grade adenocarcinoma may also resemble LGSDCA cytologically because it is characterized cytologically by papillary clusters of bland epithelial cells, often accompanied by myxoid or hyaline material. 5 Myxoid stroma was not observed in the smears of the present case. In such cases, the cytologic characteristics may be very similar to those of monomorphic adenomas.…”

The PRKD1 E710D hotspot mutation is highly specific in separating polymorphous adenocarcinoma of the palate from adenoid cystic carcinoma and pleomorphic adenoma on FNA

“…Separating PAC from ACC and PA has been a dilemma for cytopathologists and histopathologists alike for decades . In contrast to ACC and PA, PAC is a monophasic tumor and a recent study demonstrated a consistent p63‐positive/p40‐negative immunophenotype to be reserved for PAC .…”

Fine needle aspiration cytology of oral and oropharyngeal lesions with an emphasis on the diagnostic utility and pitfalls

“…PLGA is seen almost exclusively in the minor salivary glands. [19] Gibbons et al [20] described this tumor as having architectural diversity but cytological uniformity. Two cases of PLGA were misdiagnosed as ACC and PA in their study initially.…”