Fine needle aspiration of Histiocytic sarcoma

Mallya, Varuna; Bansal, Anju; Kapoor, Sujala

doi:10.4103/0970-9371.151133

Cited by 10 publications

(16 citation statements)

References 6 publications

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“…Patients with extranodal disease often undergo diagnostic fine‐needle aspiration (FNA). Although the histologic features of HS are established, its FNA cytology has been limited to a few case reports . This study evaluates the FNA cytomorphology of 8 cases of HS in 6 patients along with clinical, histopathologic, immunophenotypic, and (in 4 cases) molecular characterization.…”

Section: Introductionmentioning

confidence: 99%

Histiocytic sarcoma: New insights into FNA cytomorphology and molecular characteristics

Hung

Lovitch

Qian

2017

Cancer Cytopathology

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Although diagnosing HS with FNA alone is extremely challenging, the presence of pleomorphic and epithelioid large cells with binucleation and/or multinucleation in an inflammatory background should prompt the diagnosis of HS with judicious use of confirmatory histiocytic lineage markers. The detection of recurrent KMT2D/MLL2 alterations implicates epigenetic regulation in the pathogenesis of HS and supports the notion of transdifferentiation from a genetically similar but phenotypically distinct tumor of a different lineage. Cancer Cytopathol 2017;125:604-14. © 2017 American Cancer Society.

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Section: Introductionmentioning

confidence: 99%

Histiocytic sarcoma: New insights into FNA cytomorphology and molecular characteristics

Hung

Lovitch

Qian

2017

Cancer Cytopathology

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“…Histiocytic sarcoma is a very aggressive [1] malignant [2]- [5] and rare lymphoide tissue [6] with poor prognosis [4]. It is derived from histiocytes and it may result from stem cell transformation in neoplastic hematologic disease [3] [4].…”

Section: Introductionmentioning

confidence: 99%

“…The diagnosis is essentially based on clinics, pathology and immunohistochemistry [2]. The clinical disease onset usually represents with weigth loss, skin lesions and hepatosplenomegaly [5] but it can also be atypical.…”

Section: Introductionmentioning

confidence: 99%

“…The histiocytic sarcoma can occur at any age and can involve several parts of the body [5]. Most cases are originated in lymph nodes, but the skin and gastrointestinal tract are often other possible places of frequent origin [5].…”

Section: Introductionmentioning

confidence: 99%

“…Most cases are originated in lymph nodes, but the skin and gastrointestinal tract are often other possible places of frequent origin [5]. Most rarely, in literature, is the achievement of the pleura [6], stomach [7], bone marrow [4] and lung [3] [8], and there is one case reported in mouse with liver involvement [1].…”

Section: Introductionmentioning

confidence: 99%

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Looking for a Rarity: Histiocytic Sarcoma

Rocha¹,

Paiva²,

Cruz³

2016

JCT

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Histiocytic sarcoma is an extremely rare and very aggressive malignancy, with poor prognosis. The cases described in the literature are few and the treatment is not currently considered consensual. The clinical presentation is very variable. Its characterization is made based primarily on the histology. The authors present a case of an 82-year-old woman, with multiple adenopatic retroperitoneal and left iliac conglomerates, with left leg associated edema (extrinsic compression by conglomerates). After intensive study and approach ganglion biopsy, the histologic diagnosis revealed a histiocytic sarcoma.

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Fine‐needle aspiration findings of a rare hematopoietic neoplasm presenting as obstructive jaundice

Tracht

Ahmed

Donath

2017

Diagnostic Cytopathology

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A 51-year-old female who presented with obstructive jaundice was found to have masses in the pancreatic head and tail as well as suspicious liver and periaortic masses on imaging. Aspiration cytology of the pancreatic tail mass showed abundant large single cells with vacuolated eosinophilic cytoplasm, marked nuclear pleomorphism, large bizarre irregular nuclei, binucleation, and prominent nucleoli. Numerous cells also showed intracytoplasmic black to brown pigmentation. A cell block was obtained and extensive immunohistochemical staining was performed. S-100, HMB-45, Sox10, pancytokeratin, CK7, RCC antigen, synaptophysin, HepPar 1, inhibin, CD45, CD21, and CD123 were negative, making melanoma, epithelial malignancies, lymphoma, follicular dendritic and plasmacytoid dendritic cell neoplasms less likely. CD4 and CD56 showed partial positivity, and CD68, CD163, and CD14 were positive, supporting the diagnosis of histiocytic sarcoma. Surgical specimens and immunohistochemistry confirmed the cytologic findings. Histiocytic sarcoma is a rare aggressive malignancy of histiocytic origin with most cases presenting in adults in extranodal sites, most commonly the intestinal tract. Few cases are reported in the literature, presenting diagnostic challenges for cytopathologists when seen on fine-needle aspiration. We present the first reported case of histiocytic sarcoma presenting as a pancreatic mass, diagnosed by endoscopic ultrasound guided fine-needle aspiration (EUS-FNA). This entity is rarely described on cytology and arose in a location in which EUS-FNA is the diagnostic modality of choice. This case study highlights that cytopathologists should be aware of histiocytic sarcoma occurring in extranodal locations accessible by EUS-FNA and be familiar with the cytomorphologic appearance.

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Fine needle aspiration of Histiocytic sarcoma

Cited by 10 publications

References 6 publications

Histiocytic sarcoma: New insights into FNA cytomorphology and molecular characteristics

Histiocytic sarcoma: New insights into FNA cytomorphology and molecular characteristics

Looking for a Rarity: Histiocytic Sarcoma

Fine‐needle aspiration findings of a rare hematopoietic neoplasm presenting as obstructive jaundice

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