Quantitative understanding of the implications of growth in food demand and global changes requires a multisystem framework. Environmental and human system models can be linked via agricultural and food markets. This chapter shows how to construct a computable multiscale environmental economic model for projecting and analyzing the impacts of policies and changes. This analysis requires assumptions about (1) how demand and supply in each market are determined, (2) the relevant scales for each market, and (3) how markets are linked. The market-clearing conditions are based on economic theories at local, regional, and global scales. This chapter introduces the general conditions for constructing a gridded model based on quantitative frameworks widely employed in microeconomics, regional economics, international trade, and land use. To provide a comprehensive picture of how the model works, this chapter illustrates how the equilibrium in agricultural and food markets is determined and how the markets are linked to human and environmental system. The overall model structure shows how local land and water resources can be linked to regional agricultural production and global food consumption.