Fine structure of the neuro-insular complex type II in the cat.

Böck, Peter

doi:10.1679/aohc.49.189

Cited by 10 publications

(11 citation statements)

References 23 publications

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“…During prenatal development, i.e. from the 14th to 40th g.w., NIC I was present in the following forms: single ( Figure 1 A- Thus, the various forms of NIC that we observed in the human fetal pancreas are similar in their morphological organization to the NIC, which were found in the fetal and adult pancreas of other mammals [26][27][28][29].…”

Section: Structure Of Nic In Human Pancreassupporting

confidence: 63%

“…Similarly, various NIC I representing all transitional forms between pure islets with a single neuron and pure ganglia containing only a few endocrine cells have been detected in the pancreas of the cat [28]. Based on these findings, Böck [28] In addition to neurons and nerve fibers, glial cells immunopositive for S100 protein and glial fibrillary acidic protein (GFAP) have been detected at the periphery of islets in many mammals [3,13,14,32,34]. These cells have a triangular or spindle-like shape and possess long, thin leaf-like processes which cover endocrine cells, separating them from the connective tissue and from the acini.…”

Section: Morphological Organization Of Nic In the Mammalian Pancreasmentioning

confidence: 85%

“…It has also been shown that various transitional forms between the classical NIC II in which endocrine cells are located inside nerve bundles and innervated islets are present in the pancreas of the dog [27]. Similarly, various NIC I representing all transitional forms between pure islets with a single neuron and pure ganglia containing only a few endocrine cells have been detected in the pancreas of the cat [28]. Based on these findings, Böck [28] In addition to neurons and nerve fibers, glial cells immunopositive for S100 protein and glial fibrillary acidic protein (GFAP) have been detected at the periphery of islets in many mammals [3,13,14,32,34].…”

Section: Morphological Organization Of Nic In the Mammalian Pancreasmentioning

confidence: 89%

“…or with the processes of glial cells (Schwann cells or satellite cells) [27][28][29]. The gap between the plasmalemma of endocrine cells and glial cells is about 30 nm [28,29].…”

Section: Morphological Organization Of Nic In the Mammalian Pancreasmentioning

confidence: 99%

“…The gap between the plasmalemma of endocrine cells and glial cells is about 30 nm [28,29]. Desmosome-like contacts and synaptic contacts between endocrine cells and glial cells or axons have occasionally been found by some authors [28]. As in histological studies, various morphological forms of the NIC were detected using electron microscopy.…”

Section: Morphological Organization Of Nic In the Mammalian Pancreasmentioning

confidence: 99%

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Neuro-Insular Complexes in the Human Pancreas

Krivova¹,

Proshchina²,

Barabanov³

et al. 2017

Challenges in Pancreatic Pathology

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It is well known that pancreatic islets are complex structures composed of endodermally derived endocrine cells, integrated with endothelial cells and other cells, originating from the mesoderm, and innervated by nerve fibers that have a neuroectodermal origin. In our studies, we focused on the interactions between the structures of the nervous system and endocrine cells, the so-called neuro-insular complexes, in the human pancreas. In this chapter, we present our results and literature data concerning the morphological organization of neuro-insular complexes in humans and other mammals. We also discuss the possible functional role of neuro-insular complexes, such as the involvement of the nervous system in the regulation and synchronization of islet hormone secretion and the morphogenetic plasticity of the endocrine pancreas in adults, as well as in the regulation of endocrine cell proliferation and maturation during prenatal development of the pancreas.

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Section: Structure Of Nic In Human Pancreassupporting

confidence: 63%

Section: Morphological Organization Of Nic In the Mammalian Pancreasmentioning

confidence: 85%

Section: Morphological Organization Of Nic In the Mammalian Pancreasmentioning

confidence: 89%

“…or with the processes of glial cells (Schwann cells or satellite cells) [27][28][29]. The gap between the plasmalemma of endocrine cells and glial cells is about 30 nm [28,29].…”

Section: Morphological Organization Of Nic In the Mammalian Pancreasmentioning

confidence: 99%