Fine Structures of Merkel Cells and Associated Nerve Fibers in the Epidermis of Certain Mammalian Species

Kurosumi, Kazumasa; Kurosumi, Utako; Suzuki, Hiroyuki

doi:10.1679/aohc1950.30.295

Cited by 42 publications

(25 citation statements)

References 13 publications

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“…In fungiform papillae, taste buds were found in epithelium as late as at 94 days of prenatal development. If we assume, together with some other authors (Fujimoto and Murray 1970;Kurosumi et al 1969;Munger 1965;SpoendHn 1970;Takeda and Hoshino 1975, and others), that the site for commencement of a bud is determined by a contact of epithelial cells with a nerve fibre, then, out of the three types of sensory papillae, the fungiform papillae will be the last to be innervated. _ An interesting' finding was the presence of the "secondary" openings of gll .…”

Section: Discussionmentioning

confidence: 89%

The Morphogenesis of Circumvallate Papillae and the Differentiation of Taste Buds in the Porcine Foetus from Day 76 till Birth and in the Adult Pig

Tichý¹

1991

Acta Vet. Brno

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Tichy F.: The Morphogenesis of Circumvallate Papillae and the Differentiation of Taste Buds in the Porcine Foetusfrom Day 76 till Birth and in the Adult Pig. Acta vet. Brno, 60, 1991: 307-315.The development and morphology of some lingual structures were studied in the tongues of porcine foetuses at 76, 81 and 94 days after fertilization, of piglets 2 days after birth and of adult pigs. Special attention was given to the morphogenesis of circumvallate papillae and the differentiation of taste buds in papillary epithelium. The formation of the other types of papillae, and the development of the lamina propria mucosae and the related structures were also investigated.Taste buds prevailed in the wall epithelium of the circumvallate papilla, while in its dorsal surface they occurred only occasionally during the first stages of the period studied. The amount of taste buds increased gradually in foliate papillae. In the period under study taste buds showed distinct differentiation of their cells.The porus gustatorius formed immediately after the taste bud reached the surface of epithelium."Secondary" ducts of the gll. gustatoriae observed in circumvallate papillae in the late prenatal periods were present till birth.The development of the other lingual papillae followed that of circumvallate papillae. Tongue, papillae, taste bud, development, swineThe structure and composition of lingual mucosa is well understood at the levels of both light and electron microscopy. The basic information on the structure of the taste organ, based on electron microscopic observations, in laboratory animals as well as in man was reported early in this century (Kolmer 1910;Retzius .1912;Heidenhain 1914).The result of a number of investigations into the ultrastructure of taste buds in some animal species (Beidler and Smallman 1965;De Lorenzo 1958;Farbman 1965a, Farbman and Tonkers 1971;Fujimoto and Murray 1970;Murray 1969Murray , 1971Murray , 1973Murray and Murray 1960, 1967Murray, Murray and Fujimoto 1969;Takeda and Hoshino 1975;Uga 1966Uga , 1969 and others) contributed significantly to the understanding of taste perception mechanisms. They provided grounds for the development of methods for studying biochemistry and physiology of taste perception (Beidler 1970;De Han and Graziadei 1971;Hirata and Nada 1975;Spoendlin 1970;Takeda 1976; Beauchamp and Cowart 1986, and others).Attention has also been paid to the development of the taste organ in man and various mammalian species (Bredler and Smallman 1965;Farbman 1965bFarbman , 1971 Takeda 1972 and others).Less information is available on the development of mucosal structures of the tongue in relation to periods of development in farm animals. Particularly poor are data on the time of commencement of taste buds and on the changes in the gustatory receptor occurring during ontogenesis.

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Section: Discussionmentioning

confidence: 89%

The Morphogenesis of Circumvallate Papillae and the Differentiation of Taste Buds in the Porcine Foetus from Day 76 till Birth and in the Adult Pig

Tichý¹

1991

Acta Vet. Brno

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“…A lot of papers on the Merkel cell have appeared during the last two decades (CAUNNA, 1962;MUNGER, 1965MUNGER, , 1977MUSTAKALLIO and KIISTALA, 1967;SMITH, 1967SMITH, , 1970IGGO and MUIR, 1969;KUROSUMI et al, 1969;BREATHNACH, 1971;LYNE and HOLLIS 1971;HASHIMOTO, 1972 a, b;ANDRES and DURING, 1973;NAFSTAD, 1971a, b;WINKELMANN and BREATHNACH, 1973;ENGLISH, 1974ENGLISH, , 1977WHEITEAR, 1974;BUDTZ and LARSEN, 1975;HALATA, 1975;SAXOD, 1978;TWEEDLE, 1978;TACHIBANA, 1978TACHIBANA, , 1979, and many others). But the life history, including the developmental origin, of the Merkel cell is not necessarily clear.…”

Section: Discussionmentioning

confidence: 99%

Merkel cell development in the wound healing in the labial mucosa of adult rabbits.

Tachibana

Ishizeki

1981

Arch. Histol. Jap., Arch. Histol. Jpn

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“…Merkel cells of the epical synaptic contacts are not found (MUNGER, 1965;MUSTAKALLIO and KIISTALA, 1967;KUROSUMI, KUROSUMI and SUZUKI, 1969;HALATA, 1970). KUROSUMI, KUROSUMI and SUZUKI (1969) speculated that the dark-cored vesicles of Merkel cells might contain a transmitter substance which was released from the cell to stimulate the nerve ending. DE HAN and GRAZIADEI (1971) histochemically proved that the dark-cored vesicles in the receptor cells of frog taste buds contained norepinephrine.…”

Section: Discussionmentioning

confidence: 99%

Fine Structure of Taste Buds in the Rat

Takeda

Hoshino

1975

Arch. Histol. Jap., Arch. Histol. Jpn

148

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Summary.The taste buds of rat circumvallate papillae contain three distinct types of cells. The type I (dark) cell is characterized by the presence of dense round granules, which are precursor to the dense substance of the taste pore. The granules are discharged into the pore by exocytosis.The type II (light) cell is filled with numerous vesicles and smooth-surfaced endoplasmic reticulum. The type III cell contains in its basal cytoplasm characteristic dark-cored vesicles and masses of clear vesicles, and makes synapse-like contacts with nerve fibers.The fine structure of foliate buds corresponds to that of circumvallate papillae, while fungiform buds differ in their apical regions.In the latter the pore is filled with vesicles alone, and the type I cell contains rod-shaped granules of moderate density.When polysaccharides were examined by means of the periodic acid-silver methenamine and the periodic acid-thiocarbohydrazide methods, slightly positive reactions were found on the dense granules of the type I cell and the dense substance in the pore, whereas the membranes of the pore vesicles, apical cytoplasmic processes and cytoplasmic vesicles in type II cells showed intense reactions.The ultrastructure of the mammalian taste buds was previously studied in rabbits (ENGSTROM and RYTZNER, 1956;TRUJILLO-CENOZ, 1957;DE LORENZO, 1958;NEMETSCHEK-GANSLER and FERNER, 1964;SCALZI, 1967;MURRAY and MURRAY, 1967; MURRAY, MURRAY and FUJIMOTO, 1969;FUJIMOTO and MURRAY, 1970), rats (GRAY and WATKINS, 1965; FARBMAN, 1965a, b;UGA, 1969), guinea pigs (SPOENDLIN, 1970), monkeys (MURRAY and MURRAY, 1960), and men (GRAZIADEI, 1969;MATTHEWS and MARTIN, 1971;TAKEDA, 1972). These studies have shown disagreement with regard to their cellular composition and the function of the individual cells. In particular, it remains to be established what cell type should be designated as the gustatory receptor. FARBMAN (1965a, b) distinguished the taste buds in rat fungiform papillae into four cell types which were called the peripheral, basal, type I (dark) and type II (light) cells. He considered the type I cell as the gustatory receptor.On the other hand, UGA (1969) who examined the rat circumvallate papillae, divided taste bud cells into two types, the light cells and the dark cells. He regarded the light cells as the gustatory element which is synaptically in contact with nerves. MURRAY, MURRAY and FUJIMOTO (1969) reported the third cell type in addition to the dark and the light ones. The cells of this type contained an aggregation of vesicles of a type generally found in synaptic regions in the basal portion of the cytoplasm, and they regarded this type as a gustatory receptor.The three primary areas of the tongue in mammals where the taste buds are commonly found are those of the circumvallate, foliate and fungiform papillae. In the rat tongue, the fungiform papillae are innervated by the chorda tympani nerve, whereas the circumvallate papillae and the posterior folds of the foliate papillae are 395

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Fine Structures of Merkel Cells and Associated Nerve Fibers in the Epidermis of Certain Mammalian Species

Cited by 42 publications

References 13 publications

The Morphogenesis of Circumvallate Papillae and the Differentiation of Taste Buds in the Porcine Foetus from Day 76 till Birth and in the Adult Pig

The Morphogenesis of Circumvallate Papillae and the Differentiation of Taste Buds in the Porcine Foetus from Day 76 till Birth and in the Adult Pig

Merkel cell development in the wound healing in the labial mucosa of adult rabbits.

Fine Structure of Taste Buds in the Rat

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