Fine-Tuning Oligodendrocyte Development by microRNAs

Barca-Mayo, Olga; Lü, Qing

doi:10.3389/fnins.2012.00013

Cited by 56 publications

(48 citation statements)

References 74 publications

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“…Multiple miRNAs have been associated with oligodendrocyte maturation during embryonic development [15,18,20,21]. Whether these miRNAs play important roles in adult oligodendrocytes are poorly understood.…”

Section: Discussionmentioning

confidence: 99%

“…Using miRNA array, several studies have identified miRNAs related to oligodendrocyte maturation [15–17]. Multiple miRNAs including miR-219, miR-138, miR17-92 and miR-338 have been found to modulate the proliferation or differentiation of OPCs into mature oligodendrocytes [15,18–22]. However, the functional roles of miRNAs in stroke-induced oligodendrogenesis have not been reported.…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA-146a Promotes Oligodendrogenesis in Stroke

et al. 2016

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Stroke induces new myelinating oligodendrocytes that are involved in ischemic brain repair. Molecular mechanisms that regulate oligodendrogenesis have not been fully investigated. MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally regulate gene expression. MiR-146a has been reported to regulate immune response, but the role of miR-146a in oligodendrocyte progenitor cells (OPCs) remains unknown. Adult Wistar rats were subjected to the right middle cerebral artery occlusion (MCAo). In situ hybridization analysis with LNA probes against miR-146a revealed that stroke considerably increased miR-146a density in the corpus callosum and subventricular zone (SVZ) of the lateral ventricle of the ischemic hemisphere. In vitro, over-expression of miR-146a in neural progenitor cells (NPCs) significantly increased their differentiation into O4+ OPCs. Over-expression of miR-146a in primary OPCs increased their expression of myelin proteins, whereas attenuation of endogenous miR-146a suppressed generation of myelin proteins. MiR-146a also inversely regulated its target gene-IRAK1 expression in OPCs. Attenuation of IRAK1 in OPCs substantially increased myelin proteins and decreased OPC apoptosis. Collectively, our data suggest that miR-146a may mediate stroke-induced oligodendrogenesis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MicroRNA-146a Promotes Oligodendrogenesis in Stroke

et al. 2016

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“…At each stage, cells can be identified and isolated on the basis of temporally regulated surface antigens, which permit the selection of cells of defined mitotic and differentiation potential (Ishibashi et al, 2004;Nishiyama et al, 2009;Yuan et al, 2011;Zhang, 2001;Zhao et al, 2012). These discrete stages exhibit distinct miRNA profiles as well, that may serve to regulate translation, and thus sharpen phenotypic transitions during lineage progression (Barca-Mayo and Lu, 2012;Dugas et al, 2010;He et al, 2012;Lau et al, 2008;Mallanna and Rizzino, 2010;Shenoy and Blelloch, 2014;Shi et al, 2010;Zhao et al, 2010). AEP, anterior entopeduncular nucleus; ICM, inner cell mass; LGE, lateral ganglionic eminence; LV, lateral ventricle; MGE, medial ganglionic eminence.…”

Section: Oligoneogenesis In the Forebrainmentioning

confidence: 99%

How to make an oligodendrocyte

2015

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Oligodendrocytes produce myelin, an insulating sheath required for the saltatory conduction of electrical impulses along axons. Oligodendrocyte loss results in demyelination, which leads to impaired neurological function in a broad array of diseases ranging from pediatric leukodystrophies and cerebral palsy, to multiple sclerosis and white matter stroke. Accordingly, replacing lost oligodendrocytes, whether by transplanting oligodendrocyte progenitor cells (OPCs) or by mobilizing endogenous progenitors, holds great promise as a therapeutic strategy for the diseases of central white matter. In this Primer, we describe the molecular events regulating oligodendrocyte development and how our understanding of this process has led to the establishment of methods for producing OPCs and oligodendrocytes from embryonic stem cells and induced pluripotent stem cells, as well as directly from somatic cells. In addition, we will discuss the safety of engrafted stem cell-derived OPCs, as well as approaches by which to modulate their differentiation and myelinogenesis in vivo following transplantation.

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“…Since the role of microRNAs in myelinating glia has been a very active area of investigation, several excellent reviews have recently covered various aspects of microRNA regulation (Barca-Mayo and Lu, 2012; Dugas and Notterpek, 2011; He et al, 2011; Zheng et al, 2012). Initial studies of microRNA function in myelinating glia have focused on microarray profiling and using knockouts of Dicer, which is required for formation of mature microRNAs.…”

mentioning

confidence: 99%

MicroRNA and transcriptional crosstalk in myelinating glia

Svaren

2014

Neurochemistry International

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Several recent studies have addressed the important role of microRNA in regulation of differentiation of myelinating glia. While Schwann cells and oligodendrocytes in the peripheral and central nervous systems, respectively, exhibit significant morphological and regulatory differences, some aspects of transcriptional and microRNA regulation are shared between these two cell types. This review focuses on the intersection of microRNAs with transcriptional regulation in Schwann cell and oligodendrocyte differentiation. In particular, several microRNAs have been shown to modulate expression of critical transcription factors, and in turn, the regulation of microRNA expression is enmeshed within transcriptional networks that coordinate both coding gene and noncoding RNA profiles of myelinating cells. These hubs of regulation control both myelin gene expression as well as the cell cycle transitions of Schwann cells and oligodendrocytes as they terminally differentiate. In addition, some studies have begin to highlight the combinatorial effects of different microRNAs that establish the narrow range of gene regulation required for efficient and stable myelin formation. Overall, the integration of microRNA and transcriptional aspects will help elucidate mechanistic control of the myelination process.

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Fine-Tuning Oligodendrocyte Development by microRNAs

Cited by 56 publications

References 74 publications

MicroRNA-146a Promotes Oligodendrogenesis in Stroke

MicroRNA-146a Promotes Oligodendrogenesis in Stroke

How to make an oligodendrocyte

MicroRNA and transcriptional crosstalk in myelinating glia

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