Fingerprint profile of Ginkgo biloba nutritional supplements by LC/ESI-MS/MS

Ding, Shujing; Dudley, Ed; Plummer, Sue; Tang, Jiandong; Newton, Russell P.; Brenton, A.G.

doi:10.1016/j.phytochem.2008.01.026

Cited by 95 publications

(79 citation statements)

References 15 publications

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“…Figure S24 (in supporting information) shows an example of DAD spectra at a retention time of 21 min (peak 8, Figure 4) obtained from an LC separation of a red onion extract. Inspection of the front (8) and tail (9) indicate that the LC peak might contain at least two compounds. DAD spectra from cy-3-gal and que-3-glu standards are also included in Figure S24.…”

Section: Selectivity In Dad Detectionmentioning

confidence: 99%

“…However, selection of ionization mode, positive or negative, will have an influence on the type of information that could be achieved but also on the sensitivity. In the literature a number of different screening or fingerprint methods have been reported, [7][8][9][10][11][12][13] where some have used, positive ionization mode, [12,13] while other have use negative ionization. [9,10] Information from pos/neg mode provides complementary information and thus some work has been done utilizing both ionization modes.…”

Section: Introductionmentioning

confidence: 99%

“…In the literature a number of different screening or fingerprint methods have been reported, [7][8][9][10][11][12][13] where some have used, positive ionization mode, [12,13] while other have use negative ionization. [9,10] Information from pos/neg mode provides complementary information and thus some work has been done utilizing both ionization modes. [8,11,14] Generally, in the literature, it is considered that negative ionization provides best sensitivity [9,14,15] but it could also be found that positive ionization are more useful for structure elucidation [11,14,15] .…”

Section: Introductionmentioning

confidence: 99%

“…[9,10] Information from pos/neg mode provides complementary information and thus some work has been done utilizing both ionization modes. [8,11,14] Generally, in the literature, it is considered that negative ionization provides best sensitivity [9,14,15] but it could also be found that positive ionization are more useful for structure elucidation [11,14,15] . Co-elution of different flavonoids are often encountered in LC making characterizing the flavonoid composition difficult, especially since standards are not always available.…”

Section: Introductionmentioning

confidence: 99%

“…[7] Some work utilizing negative ESI for analyzing anthocyanins could be found in the literature, though. [10] Due to the systematic classification of flavonoid structures [18] and knowledge of common fragmentation behavior [9,19] it is possible to calculate theoretically possible MRM transitions.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Strategies for differentiation of isobaric flavonoids using liquid chromatography coupled to electrospray ionization mass spectrometry

Fridén

Sjöberg

2014

J. Mass Spectrom.

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Flavonoids are a class of secondary plant metabolites existing in great variety. Due to this variety identification can be difficult, especially as overlapping compounds in both chromatographic separations and mass spectrometric detection are common. Methods for distinguishing isobaric flavonoids using MS 2 Additional supporting information may be found in the online version of this article at the publisher's web site.3

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Section: Selectivity In Dad Detectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Strategies for differentiation of isobaric flavonoids using liquid chromatography coupled to electrospray ionization mass spectrometry

Fridén

Sjöberg

2014

J. Mass Spectrom.

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Urinary excretion of ginkgolide terpene lactones following acute consumption of Ginkgo biloba extract

2013

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Urinary biomarkers of plant food supplement (PFS) exposure/ intake represent an accurate, non-subjective tool for determining PFS consumption in humans with applications ranging from epidemiology to subject compliance in clinical trials. Ginkgo biloba remains one of the worlds most popular PFS, yet few studies have investigated the uptake and metabolism of its primary unique bioactives: the terpene lactones. To this end, we conducted a dual-dose, acute crossover intervention using Ginkgo biloba supplements in healthy participants (n=12).Pooled 24-hr urine samples were analysed by triple quadrupole LC-MS-MS. We observed that bilobalide, and ginkgolides A and B were passed into urine intact and in a dose-dependent manner. Low levels of intact ginkgolides C and J were also excreted. To our knowledge, this is the first study to report intact ginkgolide J in urine following oral consumption of ginkgo supplements, and is also the first to account for excreted terpene lactones as a proportion of dose.

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Differentiating parts of Cinnamomum cassia using LC‐qTOF‐MS in conjunction with principal component analysis

Chen

et al. 2016

Biomedical Chromatography

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Cinnamon bark (Rou Gui in Chinese), cinnamon twig (Gui Zhi) and shaved cinnamon bark (Gui Sin) have been widely used as spices and in traditional Chinese medicine since ancient times. On-going issues related to quality and authenticity necessitate the development of analytical methods capable of providing an objective evaluation of samples. In this study, chemical fingerprints of cinnamon bark, cinnamon twigs and shaved cinnamon bark were established using liquid chromatography quadruple time-of-flight mass spectrometry in conjunction with principal component analysis (PCA). From 125 samples of cinnamon, we identified the following eight compounds and their the detection ratios: coumarin, cinnamaldehyde, cinnamyl alcohol, cinnamic acid, 2-hydroxycinnamaldehyde, 2-hydroxycinnamic acid, 2-methoxycinnamaldehyde and 4-methoxycinnamaldehyde. Of these, 4-methoxycinnamaldehyde presented the largest variations in detection ratio, making up 64.0, 97.4 and 50.0% in cinnamon bark, cinnamon twig, and shaved cinnamon bark, respectively. The quantities of cinnamyl alcohol, coumarin and cinnamaldehyde also varied between the three parts of the plant. Chemical fingerprints of the three cinnamon samples were established using principal component analysis, the results of which indicate that cinnamon bark and shaved cinnamon bark could be easily differentiated, despite a marked similarity in outward appearance. Cinnamon twig was also shown to depart from the other clusters. The proposed method provides a fast and efficient means of identifying cinnamon herbs for quality control purposes. Copyright © 2016 John Wiley & Sons, Ltd.

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Fingerprint profile of Ginkgo biloba nutritional supplements by LC/ESI-MS/MS

Cited by 95 publications

References 15 publications

Strategies for differentiation of isobaric flavonoids using liquid chromatography coupled to electrospray ionization mass spectrometry

Strategies for differentiation of isobaric flavonoids using liquid chromatography coupled to electrospray ionization mass spectrometry

Urinary excretion of ginkgolide terpene lactones following acute consumption of Ginkgo biloba extract

Differentiating parts of Cinnamomum cassia using LC‐qTOF‐MS in conjunction with principal component analysis

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