Propagation of Love-type wave in an initially stressed porous medium over a semi-infinite orthotropic medium with the irregular interface has been studied. The method of separation of variables has been adopted to get the dispersion relation of Love-type wave. The irregularity is assumed to be rectangular at the interface of the layer and half-space. Finally, the dispersion relation of Love wave has been obtained in classical form. The presence of porosity, irregularity, and initial stress in the dispersion equation approves the significant effect of these parameters in the propagation of Love-type waves in porous medium bounded below by an orthotropic half-space. The scientific effect of porosity, irregularity, and initial stress in the phase velocity of the Love-type wave propagation has been studied and shown graphically.