Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in postmenopausal women

Vilayphiou, Nicolas; Boutroy, Stéphanie; Sornay‐Rendu, Elisabeth; Rietbergen, Bert van; Munoz, F.; Delmas, Pierre D.; Chapurlat, Roland

doi:10.1016/j.bone.2009.12.015

Cited by 153 publications

(156 citation statements)

References 31 publications

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“…(12,15) This consolidates our approach by using PCA for studying a set of bone characteristic parameters that are highly correlated, (12,15) in agreement with other authors' findings. (17,18,27) In this study, men with moderate and severe vertebral fracture were clearly described by impaired aBMD at the hip or bone strength and trabecular microarchitecture components at both the radius and tibia.…”

Section: Discussionsupporting

confidence: 89%

“…(11)(12)(13) We have shown in previous casecontrol fracture studies conducted in women that HR-pQCT images of radius and tibia could be used to determine microarchitecture (14) and-in combination with mFEA-biomechanical parameters that were associated with prevalent fracture. (12,15) These associations have also been observed by others. (16)(17)(18) Studies of men are scarce, but a recent investigation of the study of osteorporotic fractures in men (MrOS) cohort, using QCT imaging of the hip, demonstrated the ability of biomechanical properties assessed by FEA to prospectively predict hip fractures in men, independently from aBMD.…”

Section: Introductionsupporting

confidence: 84%

“…Hence, we cannot suggest that the weightbearing function of the tibia helps to preserve its microarchitecture, as opposed to what we have observed in women. (15) Fig. 1.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously shown in postmenopausal women that this model, despite its validation at the radius only, provided similar prediction of fracture when used at the tibia and at the radius. (15) In addition to failure load [N], mFEA-derived variables used in our study also included stiffness [kN/mm], the percentage of load carried by the trabecular bone at the distal and proximal surface of the volume of interest (% load trab distal, and % load trab proximal, respectively), and the average and SD values of the von Mises stress in the trabecular and cortical bone (Trab av stress and Cort av stress; Trab SD stress and Cort SD stress, all in [MPa]).…”

Section: Finite Element Analysismentioning

confidence: 99%

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Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in men

Vilayphiou

Boutroy

Szulc

et al. 2010

Journal of Bone and Mineral Research

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126

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Few studies have investigated bone microarchitecture and biomechanical properties in men. This study assessed in vivo both aspects in a population of 185 men (aged 71 AE 10 years) with prevalent fragility fractures, compared to 185 controls matched for age, height, and weight, from the Structure of the Aging Men's Bones (STRAMBO) cohort.In this case-control study, areal BMD (aBMD) was measured by DXA, bone microarchitecture was assessed by high resolution (HR)-pQCT, and finite element (mFE) analysis was based on HR-pQCT images of distal radius and tibia. A principal component (PC) analysis (PCA) was used to study the association of synthetic PCs with fracture by computing their odds ratio (OR [95%CI]) per SD change. Specific associations with vertebral fracture (n ¼ 100), and nonvertebral fracture (n ¼ 85) were also computed.At both sites, areal and volumetric BMD, cortical thickness and trabecular number, separation, and distribution were significantly worse in cases than in controls, with differences ranging from À6% to 15%. mFE-derived stiffness and failure load were 8% to 9% lower in fractures ( p < .01). No difference in load distribution was found between the two groups. After adjustment for aBMD, only differences of mFE-derived stresses, stiffness, and failure load at the tibia remained significant ( p < .05).PCA resulted in defining 4 independent PCs, explaining 83% of the total variability of bone characteristics. Nonvertebral fractures were associated with PC1, reflecting bone quantity and strength at the radius (tibia) with OR ¼

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Section: Discussionsupporting

confidence: 89%

Section: Introductionsupporting

confidence: 84%

“…Hence, we cannot suggest that the weightbearing function of the tibia helps to preserve its microarchitecture, as opposed to what we have observed in women. (15) Fig. 1.…”

Section: Discussionmentioning

confidence: 99%

Section: Finite Element Analysismentioning

confidence: 99%

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Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in men

Vilayphiou

Boutroy

Szulc

et al. 2010

Journal of Bone and Mineral Research

Self Cite

126

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show abstract

“…Computational methods have been widely used to predict bone failure during disease and after prosthetic implantation, but for many years these methods assumed that the material behaviour was homogeneous (Ulrich et al 1998;Homminga et al 2002;Vilayphiou et al 2010) or that tissue variability occurred at the microscale based on grey values from micro-CT scans (Jaecques et al 2004). More recently, various analytical (Porter 2004;Ji and Gao 2006;Hamed et al 2010;Martínez-Reina et al 2011) and computational (Ghanbari and Naghdabadi 2009;De Micheli and Witzel 2011;Yuan et al 2011) models have been proposed in order to fully predict macroscopic behaviour based on the nanostructural constituents.…”

Section: Introductionmentioning

confidence: 99%