Adhesively bonded sandwich structure with dissimilar materials becomes an important means of lightweight for the next generation of autobody closure panels. However, during the baking process, the complicated change of physical properties of the adhesive can lead to structural mismatch deformation. In this paper, a multi-physics coupling numerical model of one-component hemming adhesive during the curing process is proposed, to reveal the deformation mechanism of adhesively bonded sandwich structures quantitatively. The material constitutive model of the hemming adhesive is established, considering evolution of curing properties. The curing process of typical aluminum alloy and steel bonded sandwich structure is simulated in COMSOL Multiphysics. The predicted surface deformation of the component is verified by experiment using Digital Image Correlation (DIC) technique, which captures the full-field displacement in a non-intrusive manner. Then, the development process of surface deformation of the outer panel and residual internal stress of the adhesive layer is analyzed, and the influence of temperature cycle on the maximum deformation of the component is discussed. The results show at the beginning of holding stage, the deformed component slightly rebounds, which is related to the chemical shrinkage. Mechanical strain caused by the coefficient of thermal expansion (CTE) and stiffness difference of the inner and outer panels is dominant in the adhesive layer. Reducing the curing rate and maximum holding temperature can reduce the overall deformation of the structure.