Finite element modelling and simulations in cardiovascular mechanics and cardiology: A bibliography 1993–2004

Mackerle, Jaroslav

doi:10.1080/10255840500141486

Cited by 16 publications

(8 citation statements)

References 536 publications

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“…The increase in the popularity of stenting as a primary treatment and extension of stenting techniques to more complex lesion types has prompted innovative and competitive stent designs [Oesterle et al, 1998;Colombo et al, 2002;Mackerle, 2005]. A stent is a mesh structure used to restore the patency in stenosed arteries and provide a permanent scaffold for arterial walls.…”

Section: Introductionmentioning

confidence: 99%

Arterial Wall Mechanics and Clinical Implications After Coronary Stenting: Comparisons of Three Stent Designs

Zhao

Froemming

2012

Int. J. Appl. Mechanics

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The goal of this work is to quantitatively assess the relationship between the reported restenosis rates and stent induced arterial stress or strain parameters through finite element method. The impact of three stent designs (Palmaz-Schatz stent, Express stent, and Multilink Vision stent) on the arterial stress distributions were characterized. The influences of initial stent deployment location, stent-tissue friction, and plaque properties on the arterial stresses were also investigated. Higher arterial stresses were observed at the proximal end of the plaque. The Multilink-Vision stent induced lesser stress concentrations due to the high stiffness of the Cobalt Chromium material and thinner strut thickness. The stent-induced arterial stress concentrations were positively correlated with the reported in-stent restenosis rates, with a correlation coefficient of 0.992. Stent deployment initiated at the center of the lumen led to less arterial stress variation, while deployment closer to the thinner edge of the plaque causes higher arterial stresses. The friction between the stent and tissue was found to contribute to larger stress alternations for the plaque only. Increased plaque stiffness resulted in a reduced arterial stress concentration and clinical restenosis rate. Results presented herein suggested that arterial stresses serve as a comprehensive index factor to predict the occurrence of in-stent restenosis, which will facilitate the new stent design and surgical planning.

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Section: Introductionmentioning

confidence: 99%

Arterial Wall Mechanics and Clinical Implications After Coronary Stenting: Comparisons of Three Stent Designs

Zhao

Froemming

2012

Int. J. Appl. Mechanics

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“…A significant amount of work has been reported on the modelling of blood behaviour in arteries and microchannels (Mackerle 2005). Including the effects of RBCs, there are generally two modelling approaches.…”

Section: Introductionmentioning

confidence: 99%

Modelling and simulation of the behaviour of a biofluid in a microchannel biochip separator

Xue

Patel

Kersaudy-Kerhoas

et al. 2011

Computer Methods in Biomechanics and Biomedical Engineering

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This paper reports an investigation into the flow behaviour of a biofluid in a microchannel systems through conceptual analysis and modelling. The application is the design of a microfluidic chip developed for the separation of plasma from blood. The effect of key design features of the microchannels on the flow behaviour of the biofluid is explored. These include geometric features such as the constriction, bending channel, bifurcation and the channel length ratio between the main and side channels. The performance of each design is discussed in terms of separation efficiency of the red blood cells with respect to the rest of the medium. Particular phenomena such as the Fahraeus and Fahraeus-Lindqvist effects, the Zweifach-Fung bifurcation law and the cell-free layer are discussed. In this paper, the fluid is modelled as a single-phase flow assuming either Newtonian or Non-Newtonian behaviour to investigate the effect of the fluid viscosity on both flow and separation efficiency. For a flow rate-controlled Newtonian flow system, it is found that viscosity and outlet pressure have little effect on the velocity distribution through each of the microchannels. For a diluted fluid where the flow in the whole channel system is modelled with a uniform viscosity, less plasma is separated from blood than observed in the non-Newtonian case. This results in an increase in the flow rate ratio between the main and side channels. A comparison of Newtonian and non-Newtonian flows shows that both flows tend to behave identically with an increase in the shear strain rate.

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“…Numerical analysis has played an important role in the development of the techniques and devices for blood behaviour in arteries and microchannels (Mackerle 2005;Xuan et al 2010). Relevant modelling methods generally fall into two categories: (i) explicitly modelling for investigating the detailed behaviour of individual biocells in local mechanisms (Peskin 1977;Liu et al 2006;Ai et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Integration of geometric separation mechanisms by implementing curved constrictions in a biochip microchannel fluidic separator

Xue

Bailey

2013

Computer Methods in Biomechanics and Biomedical Engineering

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This paper investigates the effectiveness of using curved constrictions in the bifurcation region of T-type fluid separators for promoting flow development in the intervals between bifurcations. A design of biofluid separator is proposed and a mathematical analysis and a numerical simulation of the blood flow in microchannels are conducted. The design is based on a modification of an existing T-shaped biochip device which consists of a main channel and a series of perpendicularly positioned side channels. By means of bifurcation effect, the blood is separated into plasma concentration flow from the side channels and blood cell concentration flow from the main channel. In this design, curved constrictions are inserted between bifurcations to replace the original straight channel section, so that the constriction and curved channel effects can be induced apart from the existing bifurcation effect. The mathematical analysis is aimed to the flow field and shear stress of the blood fluid in the microchannel geometries employed in the current design, including bifurcation, constriction and curved channel. The numerical simulation and mathematical analysis result in agreed conclusions, giving some insights into the importance of the relevant geometries in promoting biofluid separation. The main results can be summarised as follows: (i) the constrictions can largely increase the shear stress by the ratio of square of the reduction of the sections between the constriction and parent main channel. (ii) The curved channel intervals can induce centrifugal force, smoothly transit the flow field and increase the chances depleting fluid from the cell-free layer. (iii) The thickness of the boundary layer skimmed into the side channels from the main channel is decreased in this design and can be controlled, falling into the cell-free layer region by adjusting the geometry of the side channels.

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Finite element modelling and simulations in cardiovascular mechanics and cardiology: A bibliography 1993–2004

Cited by 16 publications

References 536 publications

Arterial Wall Mechanics and Clinical Implications After Coronary Stenting: Comparisons of Three Stent Designs

Arterial Wall Mechanics and Clinical Implications After Coronary Stenting: Comparisons of Three Stent Designs

Modelling and simulation of the behaviour of a biofluid in a microchannel biochip separator

Integration of geometric separation mechanisms by implementing curved constrictions in a biochip microchannel fluidic separator

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