Finite Element Simulation and Experimental Test of Ovine Corneal Tissue Cutting Process in Cataract Surgery Operation

Band, Hamed Band; Arbabtafti, Mohammadreza; Nahvi, Ali; Zarei-Ghanavati, Mehran

doi:10.5829/ije.2021.34.05b.27

Cited by 1 publication

(1 citation statement)

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“…Finite element method was used in this study to simulate the problem. This method has various applications in different fields [16][17][18], as it can help us evaluate the effects of different parameters simultaneously and reduce the cost and time of our engineering investigations. In this computational analysis, the geometry of the problem is a 3D model of a cell-bioreactor complex that consists of a cell layer, membrane, silicon layer, and bioreactor (Figure 1).…”

Section: Methodsmentioning

confidence: 99%

In Silico Analysis of Stem Cells Mechanical Stimulations for Mechnoregulation Toward Cardiomyocytes

Ebad

Vahidi

2022

IJE

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Because of the ability of stem cells to self-renew and differentiate into cardiomyocytes, they are optimal cell sources for cardiac tissue engineering. Since heart cells experience cyclic strain and pulsatile flow in vivo, these mechanical stimuli are essential factors for stem cell differentiation. This study aimed to investigate the effect of a combination of pulsatile flow and cyclic strain on the shear stress created on the embryonic stem cell layer with a elastic property in a perfusion bioreactor by using the fluid-solid interaction (FSI) method. In this study, the frequency and stress phase angle had been assumed as a variable. The results show that the maximum shear stress at frequencies of 0.33, and 1 Hz and with frequency differences in cyclic strain (0.33 Hz) and pulsatile flow (1 Hz) are 0.00562, 0.02, and 0.01 dyn/cm², respectively. Moreover, in the stress phase angles 0, 𝜋 4 ⁄ , and 𝜋 2 ⁄ , the maximum shear stress are equal to 0.00562, 0.009, and 0.014 dyn/cm², respectively. The results of this study can be an effective step in developing cardiac tissue engineering and a better understanding of the effects of mechanical stimuli on stem cell differentiation.

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Section: Methodsmentioning

confidence: 99%