In this article, an extended state observer‐based finite‐region control scheme is presented for two‐dimensional Markov jump systems with unknown mismatched disturbances. The mathematical model of the two‐dimensional Markov jump systems is built on the well‐known Roesser model. By establishing special recursive formulas and utilizing the 2‐D Lyapunov function theory, sufficient conditions are obtained, which prove that the resultant system is finite‐region bounded, if some linear matrix inequalities are achieved. Then, we provide an algorithm to solve the extended state observer‐based controller gains. With the proposed control scheme, the external disturbances can be actively rejected from the system outputs. To conclude, a numerical example based on the Darboux equation is provided to demonstrate the validity and effectiveness of the devised control scheme.