Firing behaviour of squirrel monkey eye movement‐related vestibular nucleus neurons during gaze saccades

McCrea, R. A.; Gdowski, Greg T.

doi:10.1113/jphysiol.2002.027797

Cited by 42 publications

(33 citation statements)

References 40 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, there is physiological evidence that the VOR stage of an eye-head gaze shift is not directed in the central nervous system by normal VOR-associated activity (McCrea and Gdowski 2003). The tacit separation into two movement stages seems to derive from the case of fairly small shifts, where the gaze is nearly on target before the head movement even begins (e.g., Guitton and Volle 1987).…”

Section: A Note On Movement Amplitudesmentioning

confidence: 98%

Variables Contributing to the Coordination of Rapid Eye/Head Gaze Shifts

Hanes

McCollum

2006

Biol Cybern

View full text Add to dashboard Cite

In this article results of several published studies are synthesized in order to address the neural system for the determination of eye and head movement amplitudes of horizontal eye/head gaze shifts with arbitrary initial head and eye positions. Target position, initial head position, and initial eye position span the space of physical parameters for a planned eye/head gaze saccade. The principal result is that a functional mechanism for determining the amplitudes of the component eye and head movements must use the entire space of variables. Moreover, it is shown that amplitudes cannot be determined additively by summing contributions from single variables. Many earlier models calculate amplitudes as a function of one or two variables and/or restrict consideration to best-fit linear formulae. Our analysis systematically eliminates such models as candidates for a system that can generate appropriate movements for all possible initial conditions. The results of this study are stated in terms of properties of the response system. Certain axiom sets for the intrinsic organization of the response system obey these properties. We briefly provide one example of such an axiomatic model. The results presented in this article help to characterize the actual neural system for the control of rapid eye/head gaze shifts by showing that, in order to account for behavioral data, certain physical quantities must be represented in and used by the neural system. Our theoretical analysis generates predictions and identifies gaps in the data. We suggest needed experiments.

show abstract

Section: A Note On Movement Amplitudesmentioning

confidence: 98%

Variables Contributing to the Coordination of Rapid Eye/Head Gaze Shifts

Hanes

McCollum

2006

Biol Cybern

View full text Add to dashboard Cite

show abstract

“…Although Old World primates use the eyes to determine direction of gaze in addition to head, Calltrichids appear to rely predominantly on head-direction cues (Santos and Hauser, 1999). This difference likely reflects the fact that larger monkeys and apes often move their eyes only to shift gaze, while marmosets tend to rotate their head rather than their eyes when shifting their gaze (Heiney and Biazquez, 2011; McCrea and Gdowki, 2003). Marmosets have been shown to perform geometrical gaze following, using gaze cues of other individuals to orient towards objects beyond their line of sight (Burkart and Heschl, 2006), although their understanding of what is seen by the other individual (i.e, visual access) is less clear (Burkart et al, 2007; Rosati and Hare, 2009).…”

Section: Paradigms To Investigate the Neurobiology Of Marmoset Smentioning

confidence: 99%

Marmosets: A Neuroscientific Model of Human Social Behavior

Miller

Freiwald

Leopold

et al. 2016

Neuron

283

235

View full text Add to dashboard Cite

The common marmoset (Callithrix jacchus) has garnered interest recently as a powerful model for the future of neuroscience research. Much of this excitement has centered on the species’ reproductive biology and compatibility with gene editing techniques, which together have provided a path for transgenic marmosets to contribute to the study of disease as well as basic brain mechanisms. In step with technical advances is the need to establish experimental paradigms that optimally tap into the marmosets’ behavioral and cognitive capacities. While conditioned task performance of a marmoset can compare unfavorably with rhesus monkey performance on conventional testing paradigms, marmosets’ social cognition and communication are more similar to that of humans. For example, marmosets are amongst only a handful of primates that, like humans, routinely pair bond and care cooperatively for their young. They are also notably pro-social and exhibit social cognitive abilities, such as imitation, that are rare outside of the Apes. In this review, we describe key facets of marmoset natural social behavior and demonstrate that emerging behavioral paradigms are well suited to isolate components of marmoset cognition that are highly relevant to humans. These approaches generally embrace natural behavior and communication, which has been rare in conventional primate testing, and thus allow for a new consideration of neural mechanisms underlying primate social cognition and communication. We anticipate that through parallel technical and paradigmatic advances, marmosets will become an essential model of human social behavior, including its dysfunction in nearly all neuropsychiatric disorders.

show abstract

“…The notable point here is that, regardless of the degree of reported attenuation of VOR during gaze shifts, decreased VOR functionality has been observed by multiple investigators. The results of these behavioral studies have been complemented by the finding of suppression, during gaze shifts, of the head velocity responses of VOR-mediating, position-vestibular-pause (PVP) neurons in the vestibular nuclei (McCrea and Gdowski 2003;Roy and Cullen 2002). This suppression of head velocity-related PVP responses was greater for rapid gaze shifts than for gaze pursuit.…”

Section: Head-pursuit Responses: What Is Being Signaled?mentioning

confidence: 98%

Gaze Pursuit Responses in Nucleus Reticularis Tegmenti Pontis of Head-Unrestrained Macaques

Suzuki

Betelak²,

Yee³

2009

Journal of Neurophysiology

View full text Add to dashboard Cite

Suzuki DA, Betelak KF, Yee RD. Gaze pursuit responses in nucleus reticularis tegmenti pontis of head-unrestrained macaques. J Neurophysiol 101: 460 -473, 2009. First published November 5, 2008 doi:10.1152/jn.00615.2007. Eye-head gaze pursuit-related activity was recorded in rostral portions of the nucleus reticularis tegmenti pontis (rNRTP) in alert macaques. The head was unrestrained in the horizontal plane, and macaques were trained to pursue a moving target either with their head, with the eyes stationary in the orbits, or with their eyes, with their head voluntarily held stationary in space. Head-pursuit-related modulations in rNRTP activity were observed with some cells exhibiting increases in firing rate with increases in head-pursuit frequency. For many units, this head-pursuit response appeared to saturate at higher frequencies (Ͼ0.6 Hz). The response phase re:peak head-pursuit velocity formed a continuum, containing cells that could encode head-pursuit velocity and those encoding head-pursuit acceleration. The latter cells did not exhibit head position-related activity. Sensitivities were calculated with respect to peak head-pursuit velocity and averaged 1.8 spikes/s/deg/s. Of the cells that were tested for both head-and eye-pursuit-related activity, 86% exhibited responses to both head-and eye-pursuit and therefore carried a putative gaze-pursuit signal. For these gaze-pursuit units, the ratio of head to eye response sensitivities averaged ϳ1.4. Pursuit eccentricity seemed to affect head-pursuit response amplitude even in the absence of a head position response per se. The results indicated that rNRTP is a strong candidate for the source of an active headpursuit signal that projects to the cerebellum, specifically to the target-velocity and gaze-velocity Purkinje cells that have been observed in vermal lobules VI and VII. I N T R O D U C T I O NProper visual function is dependent on the accurate pointing of the fovea toward visual objects of interest. Rotations of the eyeball are the common means of accomplishing this foveation. However, head movements often accompany eye movements when large gaze shifts are required as we navigate our visual environment. Although much is known about the neuronal mechanisms involved with rotating the eyeball, less is known about the control of head movements.The numerous motor-related inputs to the nucleus reticularis tegmenti pontis (NRTP) together with functions known to date indicate that NRTP could be involved with the coordinated control of eye-and-head motor behavior. Projections to NRTP include inputs from the frontal and supplementary eye fields and the premotor and motor cortices (Brodal 1980a;Giolli et al. 2001;Hartmann-von Monakow et al. 1981;Huerta et al. 1986; Künzle and Akert 1977;Leichnetz 1986;Leichnetz et al. 1984; Shook et al. 1990;Stanton et al. 1988). Both the frontal eye field and NRTP have been shown to be involved with the control of smooth pursuit eye movements (Gottlieb et al. 1993(Gottlieb et al. , 1994Keating 1991;Lynch 1987;MacAvoy 1991;Ono...

show abstract

Firing behaviour of squirrel monkey eye movement‐related vestibular nucleus neurons during gaze saccades

Cited by 42 publications

References 40 publications

Variables Contributing to the Coordination of Rapid Eye/Head Gaze Shifts

Variables Contributing to the Coordination of Rapid Eye/Head Gaze Shifts

Marmosets: A Neuroscientific Model of Human Social Behavior

Gaze Pursuit Responses in Nucleus Reticularis Tegmenti Pontis of Head-Unrestrained Macaques

Contact Info

Product

Resources

About