First and second wave of coronavirus-19 disease: A comparative study in patients hospitalized in an ICU of a third-level university hospital

González-Castro, A.; Fito, Elena Cuenca; Fernandez, A; Escudero, P.; Borregán, Juan Carlos Rodríguez; Peñasco, Yhivian

doi:10.1016/j.medine.2021.12.008

Cited by 4 publications

(8 citation statements)

References 9 publications

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“…After more than a year and a half since the emergence of the SARS-CoV-2, nearly all countries have reported several waves of the pandemic, with a higher severity of the virus during the second or third waves, where, for example, in Djibouti, we noticed a remarkable increase in the number of reported severe cases and fatalities, compared with the first wave 5 6. The same pattern occurred across Africa 7.…”

Section: Introductionmentioning

confidence: 51%

“…The mortality rate during the second wave in Djibouti was higher than the first wave as was true for most of the countries in the region and globally 5 6. The total number of reported deaths during this period reached 154 fatalities, with the highest number of reported fatalities from 4 to 17 April 2021 (from epi week 14 to 15/2021) for a total of 42 deaths.…”

Section: Epidemiological Surveillance In Djiboutimentioning

confidence: 86%

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Epidemiology of the first and second waves of COVID-19 pandemic in Djibouti and the vaccination strategy developed for the response

et al. 2022

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Since the first case of COVID-19 in Djibouti in March 2020 up to the end of May 2021, the country experienced two major epidemic waves of confirmed cases and deaths. The first wave in 2020 progressed more slowly in Djibouti compared with other countries in the Eastern Mediterranean Region. The second wave in 2021 appeared to be more aggressive in terms of the number and severity of cases, as well as the overall fatality rate. This study describes and analyses the epidemiology of these two waves of the COVID-19 pandemic in Djibouti and highlights lessons learnt from the National Plan for Introduction and Deployment of COVID-19 vaccines developed and implemented by the Ministry of Health of Djibouti.From 17 March 2020 up to 31 May 2021, Djibouti officially reported 11 533 confirmed cases of COVID-19 with 154 related deaths (case fatality rate, CFR: 1.3%), with an attack rate of 1.2%. The first epidemic wave began in epidemiological week 16/2020 (12–18 April) and ended in epidemiological week 25/2020 (14–20 June) with 4274 reported cases and 46 deaths (CFR: 1.1%). The second wave began in epidemiological week 11/2021 (14–20 March) and ended in epidemiological week 18/2021 (2–8 May) with 5082 reported cases and 86 deaths (CFR: 1.7%).A vaccination campaign was launched by the President of the Republic in March 2021; approximately 1.6% of the population were vaccinated in only two months’ time. Early Preparedness, multisectoral and multicoordinated response, and collaboration with WHO are among the major lessons learnt during the pandemic in Djibouti.

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Section: Introductionmentioning

confidence: 51%

Section: Epidemiological Surveillance In Djiboutimentioning

confidence: 86%

Epidemiology of the first and second waves of COVID-19 pandemic in Djibouti and the vaccination strategy developed for the response

et al. 2022

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“… 1 , 4 , 14 , 29 These are characteristic of the disease mostly during the first and second waves of the pandemic, due to the fact that it was a new virus and the immune response was not yet trained to respond to this insult. 32 Indeed, the high mortality and disease evolution was resembled among several clinical studies, independently of the circulating SARS‐CoV‐2 variant. 11 Intriguingly, increasing evidence suggest that phenotypic and functional alterations of the immune system persist for a long period after recovery from COVID‐19.…”

Section: Discussionmentioning

confidence: 88%

“…Regarding the severe cases, the acute phase of COVID‐19 is characterized by immune alterations and a decoupling of the innate and adaptive immunity, which are associated with endothelium dysfunction and uncontrolled inflammatory responses, including lymphopenia and cytokine storm, affecting tissue integrity 1,4,14,29 . These are characteristic of the disease mostly during the first and second waves of the pandemic, due to the fact that it was a new virus and the immune response was not yet trained to respond to this insult 32 . Indeed, the high mortality and disease evolution was resembled among several clinical studies, independently of the circulating SARS‐CoV‐2 variant 11 .…”

Section: Discussionmentioning

confidence: 99%

High mobility group box 1, ATP, lipid mediators, and tissue factor are elevated in COVID‐19 patients: HMGB1 as a biomarker of worst prognosis

Vicentino

Fraga-Junior

Palazzo

et al. 2023

Clinical Translational Sci

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The severe acute respiratory syndrome coronavirus 2, the agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, has spread worldwide since it was first identified in November 2019 in Wuhan, China. Since then, progress in pathogenesis linked severity of this systemic disease to the hyperactivation of network of cytokine-driven pro-inflammatory cascades. Here, we aimed to identify molecular biomarkers of disease severity by measuring the serum levels of inflammatory mediators in a Brazilian cohort of patients with COVID-19 and healthy controls (HCs). Critically ill patients in the intensive care unit were defined as such by dependence on oxygen supplementation (93% intubated and 7% face mask), and computed tomography profiles showing ground-glass opacity pneumonia associated to and high levels of D-dimer. Our panel of mediators included HMGB1,

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“…The radiology reporting system during the pandemic included the typical, atypical, and indeterminate features of COVID-19 pneumonia on the basis of RSNA classification; the grading of suspicion (using the CO-RADS classification); and the staging of pneumonia extension based on chest CT severity score (CT-SS) with semiquantitative or quantitative methods [ 37 ]. Typical features of COVID-19 pneumonia have been reported since the Delta variant [ 54 , 67 , 68 , 69 , 70 , 71 ]. Blanca et al [ 70 ] found no significant differences in terms of mortality between the first and second waves of the pandemic.…”

Section: Lung Complicationsmentioning

confidence: 99%

A Pictorial Essay Describing the CT Imaging Features of COVID-19 Cases throughout the Pandemic with a Special Focus on Lung Manifestations and Extrapulmonary Vascular Abdominal Complications

Brogna

Bignardi

Megliola³

et al. 2023

Biomedicines

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With the Omicron wave, SARS-CoV-2 infections improved, with less lung involvement and few cases of severe manifestations. In this pictorial review, there is a summary of the pathogenesis with particular focus on the interaction of the immune system and gut and lung axis in both pulmonary and extrapulmonary manifestations of COVID-19 and the computed tomography (CT) imaging features of COVID-19 pneumonia from the beginning of the pandemic, describing the typical features of COVID-19 pneumonia following the Delta variant and the atypical features appearing during the Omicron wave. There is also an outline of the typical features of COVID-19 pneumonia in cases of breakthrough infection, including secondary lung complications such as acute respiratory distress disease (ARDS), pneumomediastinum, pneumothorax, and lung pulmonary thromboembolism, which were more frequent during the first waves of the pandemic. Finally, there is a description of vascular extrapulmonary complications, including both ischemic and hemorrhagic abdominal complications.

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First and second wave of coronavirus-19 disease: A comparative study in patients hospitalized in an ICU of a third-level university hospital

Cited by 4 publications

References 9 publications

Epidemiology of the first and second waves of COVID-19 pandemic in Djibouti and the vaccination strategy developed for the response

Epidemiology of the first and second waves of COVID-19 pandemic in Djibouti and the vaccination strategy developed for the response

High mobility group box 1, ATP, lipid mediators, and tissue factor are elevated in COVID‐19 patients: HMGB1 as a biomarker of worst prognosis

A Pictorial Essay Describing the CT Imaging Features of COVID-19 Cases throughout the Pandemic with a Special Focus on Lung Manifestations and Extrapulmonary Vascular Abdominal Complications

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