Near-wellbore formation damage and high mechanical skin is a concern on the deep water horizontal wells drilled and completed off the West Coast of Africa. Due to the typically unconsolidated sandstone reservoirs, sand control is essential, either Stand Alone Screens (SAS), or Open Hole Gravel Pack (OHGP) sandface completions are run to contain the sands. Although the drilling mud is replaced by sieved mud, and carefully controlled for solids, plugging can still occur through insufficient degradation of the filter cake. In addition, losses during the drilling of the drain and even the screen size vs. openhole diameter can also have a significant impact.Productivity impairment issues originally encountered on Rosa producer wells (Deep offshore Angola, Block 17) led to the development and testing of a unique micro-emulsion technology in 2006, for use with coiled tubing deployed remedial treatment inside the screens. The 'cake breaker' system, a stable blend of surfactant, acid and brine, was tailored for the mud system used, and designed for fast acting remedial treatment. The results of the Rosa intervention treatments proved successful and additional testing was carried out in 2007 / 2008 to benchmark the tailored system to other products on the market. The tailored system remained the system of choice and the same remedial treatment formulation was applied on some of the earlier Dalia wells (producer & injector). Treatment results were positive, and have improved further still by optimizing the formulation.Preventative treatments have also been developed, using various deployment methods. The evolution has been towards a displacement of the mud in the open hole / screen annulus, prior to displacing inside the screens. The results have been mixed however, with the remedial treatments generally proving more effective than the preventative treatments. This paper looks at the experience gained on the deep water horizontal wells in Block 17 off the west coast of Angola, namely the Rosa, Girasol, Dalia and more recently the Pazflor field. The differences in results are evaluated and the various methods and lessons learnt are presented.