First autochthone case of sporotrichosis by Sporothrix globosa in Portugal

Oliveira, Manoel Marques Evangelista; Veríssimo, Cristina; Sabino, Raquel; Aranha, João; Zancopé‐Oliveira, Rosely Maria; Sampaio, Paula; Pais, Célia

doi:10.1016/j.diagmicrobio.2013.08.023

Cited by 26 publications

(11 citation statements)

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“…The disease is also endemic in India, China, Japan, and South Africa [ 2 ]. In addition, in some countries, such as Italy [ 3 ], Portugal [ 4 ], and Greece [ 5 ], sporotrichosis sporadic clinical cases have been reported in recent years. This mycosis is caused by the members of the Sporothrix complex [ 6 ], especially by the species Sporothrix brasiliensis , S. globosa , S. mexicana , S. luriei , and, classically, S. schenckii sensu stricto [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Phenotypic Characteristics Associated with Virulence of Clinical Isolates from theSporothrixComplex

Almeida‐Paes

Oliveira

et al. 2015

BioMed Research International

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The Sporothrix complex members cause sporotrichosis, a subcutaneous mycosis with a wide spectrum of clinical manifestations. Several specific phenotypic characteristics are associated with virulence in many fungi, but studies in this field involving the Sporothrix complex species are scarce. Melanization, thermotolerance, and production of proteases, catalase, and urease were investigated in 61 S. brasiliensis, one S. globosa, and 10 S. schenckii strains. The S. brasiliensis strains showed a higher expression of melanin and urease compared with S. schenckii. These two species, however, presented similar thermotolerances. Our S. globosa strain had low expression of all studied virulence factors. The relationship between these phenotypes and clinical aspects of sporotrichosis was also evaluated. Strains isolated from patients with spontaneous regression of infection were heavily melanized and produced high urease levels. Melanin was also related to dissemination of internal organs and protease production was associated with HIV-coinfection. A murine sporotrichosis model showed that a S. brasiliensis strain with high expression of virulence factors was able to disseminate and yield a high fungal burden in comparison with a control S. schenckii strain. Our results show that virulence-related phenotypes are variably expressed within the Sporothrix complex species and might be involved in clinical aspects of sporotrichosis.

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Section: Introductionmentioning

confidence: 99%

Phenotypic Characteristics Associated with Virulence of Clinical Isolates from theSporothrixComplex

Almeida‐Paes

Oliveira

et al. 2015

BioMed Research International

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“…S. schenckii sensu stricto is considered the second most pathogenic species ( Arrillaga-Moncrieff et al 2009 ), and has a worldwide distribution, with a greater preference for tropical and subtropical humid climate countries, so the highest incidence of this mycosis occurs in Americas, Africa, Australia and Asia ( Marimon et al 2007 , Lopez-Romero et al 2011 , Oliveira et al 2011a , Chakrabarti et al 2015 ). The cases related to S. globosa occurred in humans in Europe, Asia and Americas ( Marimon et al 2007 , Liu et al 2014 , Oliveira et al 2014 ), including Brazil ( Oliveira et al 2011a , Rodrigues et al 2013b ). Regarding S. mexicana , it has been believed to be an environmental species restricted to Mexico, being isolated initially in plants from there ( Marimon et al 2007 ).…”

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confidence: 99%

Feline sporotrichosis: associations between clinical-epidemiological profiles and phenotypic-genotypic characteristics of the etiological agents in the Rio de Janeiro epizootic area

Boechat

Oliveira

Almeida‐Paes

et al. 2018

Mem. Inst. Oswaldo Cruz

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BACKGROUNDSporotrichosis is caused by species of the genus Sporothrix. From 1998 to 2015, 4,703 cats were diagnosed at the Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil. Even after the description of the Sporothrix species, the characterisation of feline isolates is not performed routinely.OBJECTIVESTo characterise the clinical isolates from cats at the species level and correlate them with the clinical and epidemiological characteristics of the cats.METHODSForty seven Sporothrix spp. isolates from cats assisted at Fiocruz from 2010 to 2011 were included. Medical records were consulted to obtain the clinical and epidemiological data. The isolates were identified through their morphological and physiological characteristics. T3B polymerase chain reaction (PCR) fingerprinting was used for molecular identification of the species.FINDINGSIn phenotypic tests, 34 isolates were characterised as S. brasiliensis, one as S. schenckii and 12 as Sporothrix spp. PCR identified all isolates as S. brasiliensis.MAIN CONCLUSIONS S. brasiliensis is the only etiological agent of feline sporotrichosis in Rio de Janeiro to date. None association was found between the isolates and the clinical and epidemiological data. In addition, we strongly recommend the use of molecular techniques for the identification of isolates of Sporothrix spp.

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“…However, as SL is reported in other countries 20-22 where L. (V.) braziliensis has not been reported, it seems that this clinical presentation is mostly due to the characteristics of the patients. In addition, as sporotrichosis has been described in different regions all over the world 23-26 , differential diagnosis may become a real challenge elsewhere.…”

Section: Discussionmentioning

confidence: 99%

Sporotrichoid leishmaniasis: a cross-sectional clinical, epidemiological and laboratory study in Rio de Janeiro State, Brazil

Carvalho

Pimentel

Conceição-Silva

et al. 2017

Rev. Inst. Med. trop. S. Paulo

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Background Atypical presentations of cutaneous leishmaniasis include sporotrichoid leishmaniasis (SL), which is clinically described as a primary ulcer combined with lymphangitis and nodules and/or ulcerated lesions along its pathway.Aims To assess the differences between patients with sporotrichoid leishmaniasis and typical cutaneous leishmaniasis (CL).Methods From January 2004 to December 2010, 23 cases of SL (4.7%) were detected among 494 CL patients diagnosed at a reference center for the disease in Rio de Janeiro State, Brazil. These 23 cases were compared with the remaining 471 patients presenting CL.Results SL predominated in female patients (60.9%, p = 0.024), with older age (p = 0.032) and with lesions in upper limbs (52.2%, p = 0.028). CL affected more men (64.5%), at younger age, and with a higher number of lesions exclusively in lower limbs (34.8%).Conclusions Differences in clinical and epidemiological presentation were found between SL patients as compared to CL ones, in a region with a known predominance of Leishmania (Viannia) braziliensis. The results are similar to the features of most of the sporotrichosis patients as described in literature, making the differential diagnosis between ATL and sporotrichosis more important in overlapping areas for both diseases, like in Rio de Janeiro State.

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First autochthone case of sporotrichosis by Sporothrix globosa in Portugal

Cited by 26 publications

References 15 publications

Phenotypic Characteristics Associated with Virulence of Clinical Isolates from theSporothrixComplex

Phenotypic Characteristics Associated with Virulence of Clinical Isolates from theSporothrixComplex

Feline sporotrichosis: associations between clinical-epidemiological profiles and phenotypic-genotypic characteristics of the etiological agents in the Rio de Janeiro epizootic area

Sporotrichoid leishmaniasis: a cross-sectional clinical, epidemiological and laboratory study in Rio de Janeiro State, Brazil

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