First basic performance evaluation of the XE-2100 haematology analyser

Abstract

T he new ly developed X E-2100 haematolog y analyser can provide complete blood counts, leukocyte diå erentials, perform reticulocyte analysis, and obtain quantitative data on nucleated red blood cells ( N RBCs) . In this study, we evaluated the basic perf ormance of this instrument using routinely obtained blood specimens treated with ethylenediaminetetraacetic acid-2K . Reproducibility, carryover, stability during storag e at 4 ë C and room temperature, and accuracy were evaluated. In this evaluation, reproducibility was g ood and little carryover was f ound. A ccurate measurements were possible f or up to 48 h of storag e. A g ood correlation between nding s with the X E-2100 and SE-9000 haematolog y analysers was f ound f or complete blood count on 210 samples tested. T he leuk ocyte diå erential obtained with the X E-2100 correlated well with eye counts and with the results obtained with the SE-9000 automated haematolog y analyser, with r values over 0.9 f or the percentag es of neutrophils, lymphocytes and eosinophils. T he precision and accuracy of N RBC and reticulocyte counts by the X E-2100 were satisfactory. W e used the X E-2100 to obtain diå erential counts f or bone marrow aspirates, and g ood correlations with manual diå erentials were obtained f or total nucleated cell count, percentag e of myeloid cells and percentag e of erythroid cells. T he perf ormance of the X E-2100 was excellent, and this instrument should be able to provide reliable data to clinical laboratories.

Stability and robustness of blood variables in an antidoping context

“…While other publications showed that the %RETI remained stable for 48 h only (Robinson, Mangin & Saugy, 2004; Voss et al. , 2008), we could not identify under the conditions of our investigation, any significant changes for the investigated variables even after 72 h of storage at approximately 4 °C (Tsuda et al. , 1999; Lippi et al.…”

Validation of a Blood Stability Score as an easy‐to‐use blood sample quality index

“…Limiting our search to studies that used automated analyzers (last 20 years), we found 15 studies that provide stability results of FBCs depending on CAT and mean temperature (T) A total of 154 CAT‐T pairs were found in these studies. These pairs were assessed as ‘stable’ (green markers in Fig.…”

“…Stability assessment of RBC indices according to the collection to analysis time (CAT) and mean storage temperature (T). One hundred and fifty‐four CAT‐T pairs obtained from 15 studies are displayed in green when no or minimal degradation in the RBC parameters was observed and in red when non‐negligible degradation was observed (Square: . Dot: .…”