First case of osteomyelitis due to Erysipelothrix rhusiopathiae: pubic osteomyelitis in a gored farmer

Denès, E.; Camilleri, Y.; Fiorenza, F.; Martín, César

doi:10.1016/j.ijid.2014.11.015

Cited by 12 publications

(9 citation statements)

References 4 publications

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“…The grouping of porcine strain ATCC 19414 T and human strain IMT9137 in an identical sequence type and in the same PFGE cluster (89.9% similarity in banding pattern) indicates that these strains may be closely related and that a zoonotic potential of animals strains should be taken into consideration. Sporadic diseases in humans have been reported and these often occurred in farmers and in other persons whose work is closely related with contaminated animals, underlining that E. rhusiopathiae infection in humans is occupationally-related [ 2 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

A combinational approach of multilocus sequence typing and other molecular typing methods in unravelling the epidemiology of Erysipelothrix rhusiopathiae strains from poultry and mammals

Janßen

Voß

Kühl

et al. 2015

Vet Res

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Erysipelothrix rhusiopathiae infections re-emerged as a matter of great concern particularly in the poultry industry. In contrast to porcine isolates, molecular epidemiological traits of avian E. rhusiopathiae isolates are less well known. Thus, we aimed to (i) develop a multilocus sequence typing (MLST) scheme for E. rhusiopathiae, (ii) study the congruence of strain grouping based on pulsed-field gel electrophoresis (PFGE) and MLST, (iii) determine the diversity of the dominant immunogenic protein SpaA, and (iv) examine the distribution of genes putatively linked with virulence among field isolates from poultry (120), swine (24) and other hosts (21), including humans (3). Using seven housekeeping genes for MLST analysis we determined 72 sequence types (STs) among 165 isolates. This indicated an overall high diversity, though 34.5% of all isolates belonged to a single predominant ST-complex, STC9, which grouped strains from birds and mammals, including humans, together. PFGE revealed 58 different clusters and congruence with the sequence-based MLST-method was not common. Based on polymorphisms in the N-terminal hyper-variable region of SpaA the isolates were classified into five groups, which followed the phylogenetic background of the strains. More than 90% of the isolates harboured all 16 putative virulence genes tested and only intI, encoding an internalin-like protein, showed infrequent distribution. MLST data determined E. rhusiopathiae as weakly clonal species with limited host specificity. A common evolutionary origin of isolates as well as shared SpaA variants and virulence genotypes obtained from avian and mammalian hosts indicates common reservoirs, pathogenic pathways and immunogenic properties of the pathogen.Electronic supplementary materialThe online version of this article (doi:10.1186/s13567-015-0216-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

A combinational approach of multilocus sequence typing and other molecular typing methods in unravelling the epidemiology of Erysipelothrix rhusiopathiae strains from poultry and mammals

Janßen

Voß

Kühl

et al. 2015

Vet Res

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“…Apart from the present case, there are only two previous confirmed reports of E. rhusiopathiae osteomyelitis in the literature ( Table 1 ): left hip osteomyelitis in a child without known exposures or previous injury [3] and pubic osteomyelitis in an adult who was thought to have suffered traumatic inoculation of the bacterium approximately 19 years earlier [4] . Two additional cases in which imaging suggested osteomyelitis but tissue cultures were negative occurred in adults with likely but unspecified occupational exposure [5] , [6] .…”

Section: Discussionmentioning

confidence: 50%

“…There are three well-defined manifestations in humans: a localized cellulitic form known as erysipeloid, a diffuse cutaneous form, and a septicemic form that is associated with endocarditis [1] . Rare manifestations include abscess formation, septic arthritis, and osteomyelitis [2] , [3] , [4] , [5] , [6] , [7] .…”

Section: Discussionmentioning

confidence: 99%

First reported case of vertebral osteomyelitis due to Erysipelothrix rhusiopathiae

Lorenz

Bouton

Caliendo

2018

IDCases

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“…The most valuable information for a possible IPS in our series was previous pelvic surgery of structures of the lesser pelvis. The extent of surgery is not decisive, as other authors also report IPS after minimal invasive surgical procedures: transrectal biopsies, postpartum conditions, robotic-assisted procedures or even simple bladder catheterizations [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Further, the incidence of IPS is expected to rise in the following decades due to an ageing population with increasing numbers of pelvic procedures and traumatic events in proximity to the symphysis such as prostatectomies, hysterectomies or fragility fractures of the pelvis [32,33].…”

Section: Discussionmentioning

confidence: 99%

Surgical debridement of infected pubic symphysitis supports optimal outcome

Wagner

Hopf

Rommens

2020

Arch Orthop Trauma Surg

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Introduction Infected pubic symphysitis (IPS) is a rare bacterial infection of the pubic symphysis that causes subpubic pain, disability and ultimately permanent immobility. Due to difficult diagnosis, patients present with long-standing complaints and consult several doctors. To date, no validated treatment protocol exists and most patients are treated conservatively with antibiotics. This study was aimed to assess the results after careful surgical debridement and pathogen-specific antibiotic treatment in IPS. Materials and methods A chart review of eight patients with proven IPS was performed. Five of eight patients filled in a specific own-developed questionnaire and could be examined clinically and radiologically at a mean of 13 months (range: 6-30 months) postoperatively. Results There were six males and two females with an average age of 69 years (range: 55-80 years). The mean duration of symptoms before surgical treatment was 10.5 months (range: 1-30 months). There were no complications due to the surgical debridement. There was no recurrence of infection at the pubic symphysis during the follow-up period. The most common pathogen was Pseudomonas aeruginosa in three patients. Mean preoperative pain, measured on the visual analogue scale (VAS, range: 0-10) for the four analysed categories in the five follow-up patients was 7.2, 30 days postoperatively 2.7 and 13 months postoperatively 0.4. There was a steady increase in the quality of life (QoL) 30 days postoperatively and at the 13 months follow-up when compared to preoperative values. Conclusions Surgical debridement is the keystone for treatment of IPS and should be combined with local and systemic antibiotic therapy.

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First case of osteomyelitis due to Erysipelothrix rhusiopathiae: pubic osteomyelitis in a gored farmer

Cited by 12 publications

References 4 publications

A combinational approach of multilocus sequence typing and other molecular typing methods in unravelling the epidemiology of Erysipelothrix rhusiopathiae strains from poultry and mammals

A combinational approach of multilocus sequence typing and other molecular typing methods in unravelling the epidemiology of Erysipelothrix rhusiopathiae strains from poultry and mammals

First reported case of vertebral osteomyelitis due to Erysipelothrix rhusiopathiae

Surgical debridement of infected pubic symphysitis supports optimal outcome

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