First case of pregnant women bacteraemia and probable early-onset neonatal infection due to Aerococcus urinae

Jost, Christelle; Breton, Bénédicte; Biran, Valérie; Khung, Suonavy; Chekroune, Sarah; Bonacorsi, Stéphane

doi:10.1016/j.nmni.2014.11.002

Cited by 9 publications

(3 citation statements)

References 13 publications

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“…Other, less common, presentations of invasive infection are peritonitis in patients receiving peritoneal dialysis [45,46], vertebral osteomyelitis [2,47], soft-tissue infections in the genital area [2,48,49], postpartum infection [50], odontogenic infection [51], joint infections [17,52] and postoperative infection [53].…”

Section: Other Invasive Aerococcal Infectionsmentioning

confidence: 99%

Aerococcus : an increasingly acknowledged human pathogen

Rasmussen

2016

Clinical Microbiology and Infection

159

140

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Aerococci have often been misidentified as streptococci in microbiology laboratories, leading to an underestimation of these bacteria as causes of human infections. An increased awareness of aerococci and the introduction of matrix-assisted laser desorption ionization time-of-flight mass spectrometry, has led to an increased isolation of Aerococcus urinae and Aerococcus sanguinicola from human urine and blood. The two species are found in human urine and can cause urinary tract infections (UTI). Aerococcus urinae can, in older males with underlying urinary tract conditions, cause invasive infections such as urosepsis or infective endocarditis. The prognosis of invasive aerococcal infections appears to be relatively favourable despite the old age of patients and their many comorbidities. Though clinical breakpoints are still not in place, aerococci seem to be sensitive to penicillins, carbapenems and vancomycin. There is synergy between penicillin and aminoglycosides against some A. urinae isolates and this combination is often used in aerococcal infective endocarditis. The treatment of complicated aerococcal UTI is not obvious as many isolates are resistant to fluoroquinolones. In addition, A. urinae is resistant to sulphamethoxazole, and there are methodological problems in the determination of trimethoprim sensitivity. In complicated UTI, ampicillin is probably a safe treatment option, whereas nitrofurantoin is probably effective in uncomplicated UTI. Treatment studies in aerococcal infections are needed as is a better understanding of the natural niches for aerococci and the pathogenesis and clinical course of aerococcal infections.

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Section: Other Invasive Aerococcal Infectionsmentioning

confidence: 99%

Aerococcus : an increasingly acknowledged human pathogen

Rasmussen

2016

Clinical Microbiology and Infection

159

140

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“…Neonates were excluded if 1. They were asymptomatic with a positive blood or CSF culture likely to be a contaminant (i.e., coagulase-negative Staphylococcus (40), Diphtheroids (41), Corynebacterium spp (40), Bacillus spp, Propionibacterium spp, Aerococcus spp (42,43) or Micrococcus spp (14,18,41); or, 2. The neonate had a positive CSF culture as a result of a drain, reservoir, shunt or intracranial surgical procedure…”

Section: Case Definitionmentioning

confidence: 99%

Population-based study of early-onset neonatal sepsis in Canada

Sgro

Kobylianskii

Yudin

et al. 2018

Paediatrics &Amp; Child Health

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Objective: To determine the incidence, types of organisms and resistance patterns involved in early-onset neonatal sepsis in Canada. Study design: Early-onset neonatal sepsis cases were identified through the Canadian Paediatric Surveillance Program. Neonates were excluded if they were asymptomatic or if intracranial procedures preceded a positive cerebrospinal fluid culture. Results: One hundred and twenty-seven cases were identified (0.17 cases per 1000 live births). Group B Streptococcus accounted for 41.7%, Escherichia coli for 35.4%. Antibiotic resistance was present in 33.9% of all cases. 55.6% of E coli cases were resistant, most commonly to ampicillin. Infecting organism species were associated with gestational age, being very low birth weight, time at sepsis presentation, maternal antibiotic prophylaxis and rupture of membranes lasting over 18 hours. Group B Streptococcus was most common in term and E coli in preterm neonates. Twenty-two per cent of E coli cases presented after 48 hours, compared to 6% of Group B Streptococcus cases. Conclusion:We identify a lower rate of early-onset neonatal sepsis than historically suggested, with differing dominant organisms based on gestational ages and other factors, as well as high rates of resistance especially among E coli cases.

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“…One study showed that 67.5% of infected patients had underlying systemic diseases, most commonly diabetes mellitus, malignancy, and dementia (18). Notably, several other types of infection due to A. urinae, as well as other Aerococcus species, have been described, including peritonitis, osteomyelitis, dental, joint, and soft-tissue infections (6,(19)(20)(21)(22)(23)(24)(25)(26). While these cases are less common than UTI and endocarditis due to A. urinae, providers need to be aware of this pathogenic organism.…”

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confidence: 99%