First case of Roussoella percutanea bursitis

Almagro-Moltó, María; Haas, Ann F.; Melcher, Carolin; Nam-Apostolopoulos, Yun-Chung; Schubert, Steffen

doi:10.1016/j.diagmicrobio.2016.10.021

Cited by 8 publications

(7 citation statements)

References 14 publications

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“…Roussoella percutanea is a novel opportunistic pathogen reported in 2014 as an etiologic agent of subcutaneous infection in immunosuppressed patients (20,21). Also, in the present study the first case of keratitis due to R. percutanea was observed.…”

Section: Discussionsupporting

confidence: 68%

Molecular and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry-Based Characterization of Clinically Significant Melanized Fungi in India

Singh

Kumar

et al. 2017

J Clin Microbiol

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Melanized or black fungi are a heterogeneous group of fungi causing cutaneous to systemic diseases with high mortality. These fungi are rarely reported as agents of human infections, primarily due to difficulties in their classical identification. In this study, we examined, using molecular methods and matrix-assisted laser desorption ioniazation-time of flight mass spectrometry (MALDI-TOF MS), the diversity of melanized fungi (MF) isolated from patients in 19 medical centers in India. Overall, during a 4-year period, 718 (5.3%) clinical specimens yielded MF. Of these, 72 (10%) isolates had clinical significance and were identified primarily by sequencing the internal transcribed spacer and large subunit (LSU) regions. MF represented 21 genera comprising 29 species, the majority of them belonging to the orders Pleosporales (50%) and Chaetothyriales (22%). Among the 29 fungal species identified in this study, only 6 (20%) species were identified by the MALDI-TOF MS due to the limited commercial database of Bruker Daltonics for MF. However, a 100% identification rate of 20 additional species identified in this study was obtained by constructing an inhouse database using 24-to 96-h-old liquid cultures. Further, the CLSI broth microdilution method revealed low MICs for posaconazole (Յ1 g/ml) and voriconazole (Յ2 g/ml) in 96% and 95% of isolates, respectively. Skin/subcutaneous and sinonasal and pulmonary phaeohyphomycosis due to MF were diagnosed in 21.4% (n ϭ 15) and 28.5% (n ϭ 20) of cases. Also, 10% of patients had central nervous system involvement (n ϭ 7), and 3 cases of fungal osteomyelitis due to Cladophialophora bantiana and Corynespora spp. were observed.

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Section: Discussionsupporting

confidence: 68%

Molecular and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry-Based Characterization of Clinically Significant Melanized Fungi in India

Singh

Kumar

et al. 2017

J Clin Microbiol

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“…Three reports of black fungal bursitis were found in the English literature [ 8 – 10 ] (Table 2 ). A patient with olecranon bursitis had a long history of post-traumatic non-infectious bursitis at the olecranon, and the fungus infected the pre-existing fluid accumulated in the bursa.…”

Section: Discussionmentioning

confidence: 99%

Chronic Kirschsteiniothelia infection superimposed on a pre-existing non-infectious bursitis of the ankle: the first case report of human infection

Nishi¹,

Okano²,

Sawada³

et al. 2018

BMC Infect Dis

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BackgroundKirschsteiniothelia is a saprophytic fungus that is abundantly present in the environment. To date, there have been no reports of human infection caused by this fungus. We report a case of Kirschsteiniothelia infection superimposed on a pre-existing non-infectious bursitis of the ankle.Case presentationAn 81-year-old immunocompetent female local farmer noticed the presence of a nodule on her right ankle 5 years before her first visit to our hospital. A cystic mass of approximately 45 mm × 30 mm was present at the tip of the right lateral malleolus. Culture of the aspirated fluid revealed visibly black colonies and characteristic blackish hyphae; nucleotide sequence of the internal transcribed spacer region was determined and compared in a GenBank database. The results indicated Kirschsteiniothelia infection.ConclusionsWe described the first case of Kirschsteiniothelia infection manifested as ankle bursitis. The disease seemed to be localized and systemic antibiotics had not been used in this case. However, continued observation is needed because of the possibility of disease progression with the pathogen.Electronic supplementary materialThe online version of this article (10.1186/s12879-018-3152-3) contains supplementary material, which is available to authorized users.

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“…The joint guidelines of the European Society of Clinical Microbiology and Infectious Diseases Fungal Infection Study Group and the European Confederation of Medical Mycology on the management of subcutaneous phaeohyphomycosis ( 9 ) recommended surgical resection (recommendation AII) along with oral azoles in immunosuppressed patients to prevent dissemination of disease (recommendation BIII). In vitro susceptibility testing, conducted for 3 isolates by Ahmed et al ( 2 ) and Almagro-Molto et al ( 7 ), revealed that P. percutanea exhibited low MIC to itraconazole, voriconazole, and posaconazole (Table). Therefore, itraconazole and posaconazole can be used in patients receiving other liver-metabolized drug therapies.…”

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confidence: 99%

“…We searched published literature on Medline and PubMed for subcutaneous phaeohyphomycoses caused by P. percutanea or R. percutanea and identified 5 cases (Table). All 5 patients originated from tropical countries including the Caribbean islands ( 5 ), Republic of the Congo ( 6 ), Somalia ( 7 ), and India ( 2 , 8 ). Including these 5 with the case-patients we identified from culture and our study patient, 7 of 10 total cases originated in India.…”

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confidence: 99%