First Cases of Coronavirus Disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020

Spiteri, Gianfranco; Fielding, James E; Diercke, Michaela; Campese, C; Enouf, Vincent; Gaymard, Alexandre; Bella, Antonino; Sognamiglio, Paola; Moros, María José Sierra; Riutort, Antonio Nicolau; Demina, Yulia V.; Mahieu, Romain; Broas, Markku; Bengnér, Malin; Buda, Silke; Schilling, Julia; Filleul, Laurent; Lepoutre, A.; Saura, C.; Mailles, Alexandra; Lévy-Brühl, Daniel; Coignard, B.; Bernard-Stoecklin, Sibylle; Behillil, Sylvie; Werf, Sylvie van der; Valette, Martine; Lina, Bruno; Riccardo, Flavia; Nicastri, Emanuele; Casas, Inmaculada; Larrauri, Amparo; Castell, Magdalena Salom; Pozo, Francisco del; Maksyutov, Rinat А.; Martin, Charlotte; Ranst, Marc Van; Bossuyt, Nathalie; Siira, Lotta; Sane, Jussi; Tegmark-Wisell, Karin; Palmérus, Maria; Broberg, Eeva; Beauté, Julien; Jorgensen, Pernille; Bundle, Nick; Pereyaslov, Dmitriy; Adlhoch, Cornelia; Pukkila, Jukka; Pebody, Richard; Olsen, Sonja J.; Ciancio, Bruno Christian

doi:10.4324/9781003141402-11

Cited by 179 publications

(215 citation statements)

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“…The clinical presentation in FF100 cases was dominated by cough, fatigue and fever, consistent with other studies (2-5, 7-9). The proportion of FF100 cases reporting fever was slightly lower than case series descriptions from China (2-5), although similar to the first cases of COVID-19 described in Europe (1). This may be due to the inclusion of non-hospitalised cases in this study as well as the European study.…”

Section: Discussionsupporting

confidence: 54%

“…The epidemiology and clinical features of early COVID-19 cases identified in China and elsewhere have been reported (2)(3)(4)(5)(6)(7). In a pre-print article, Ma et al, present a pooled analysis of 1,155 cases from seven countries with estimates of key epidemiological parameters (8) and the first identified cases in the WHO European Region have been described (1). The most commonly reported symptoms have been fever, fatigue, dry cough, myalgia and dyspnoea (1-5, 8, 9).…”

Section: Introductionmentioning

confidence: 99%

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COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis

Boddington

Charlett

Elgohari

et al. 2020

Preprint

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Objectives: Following detection of the first virologically-confirmed cases of COVID-19 in Great Britain, an enhanced surveillance study was initiated by Public Health England to describe the clinical presentation, course of disease and identify risk factors for infection of the first few hundred cases. Methods: Information was collected on the first COVID-19 cases according to the First Few X WHO protocol. Case-control analyses of the sensitivity, specificity and predictive value of symptoms and risk factors for infection were conducted. Point prevalences of underlying health conditions among the UK general population were presented. Findings: The majority of FF100 cases were imported (51.4%), of which the majority had recent travel to Italy (71.4%). 24.7% were secondary cases acquired mainly through household contact (40.4%). Children had lower odds of COVID-19 infection compared with the general population. The clinical presentation of cases was dominated by cough, fever and fatigue. Non-linear relationships with age were observed for fever, and sensitivity and specificity of symptoms varied by age. Conditions associated with higher odds of COVID-19 infection (after adjusting for age and sex) were chronic heart disease, immunosuppression and multimorbidity. Conclusion: This study presents the first epidemiological and clinical summary of COVID-19 cases in Great Britain. The FFX study design enabled systematic data collection. The study was able to characterize the risk factors for infection with population prevalence estimates setting these relative risks into a public health context. It also provides important evidence for generating case definitions to support public health risk assessment, clinical triage and diagnostic algorithms.

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Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis

Boddington

Charlett

Elgohari

et al. 2020

Preprint

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“…The exponential increase in cases since the first SARS-CoV-2 patient diagnosed in Spain (January 31, 2020) and the overload of primary and hospital care meant a great effort for the society [ 7 ]. It was necessary to adapt the public health system to the epidemiological situation, reorganizing hospitals and restructuring PC, limiting surgical activity to essential cases (emergencies and oncology) and improving the distribution of health resources (human, material and structural) [ [8] , [9] , [10] , [11] ].…”

Section: Discussionmentioning

confidence: 99%

ENT emergencies during the first wave of COVID-19 pandemic in Spain: Our experience

Herranz-Larrañeta

Klein-Rodríguez

Menéndez-Riera

et al. 2021

American Journal of Otolaryngology

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“…Covid-19 has crossed a three million mark causing more than 211000 deaths worldwide in just over three months [1]. It was started in China and spread all over the world [2,3]. Europe and the United States of America (USA) were the worst affected by SARS-Cov-2 infection.…”

Section: Introductionmentioning

confidence: 99%

A Normalized Mortality Rate Showed the Diverse Severity of COVID-19 and Its Association With Other Chronic Diseases

Kumar¹,

Renjith²,

Priscilla³

et al. 2020

Preprint

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Covid-19 has given a halt to all the activities in the world. Europe was most affected followed by the United States of America. It has taken more than 200,000 lives till now. In this study, we have assessed the severity of Covid-19 by analyzing the mortality rate in Covid-19 and other diseases to see the severity of Covid-19 and other chronic diseases. The Covid-19 data and “death rate” data caused by other diseases were downloaded from the world health organization (WHO) website. A normalized period based method was used to see the mortality rate of Covid-19 in comparison to other diseases. The deaths occurred by cardiovascular diseases, cancer, and respiratory diseases were more in number than the Covid-19 caused deaths in the 45 days period where most of the Covid-19 deaths had taken place. The severity of Covid-19 in the USA was moderate. The severity of Covid-19 in Asian countries was found to be at a low. Europe showed the highest diversity in the mortality rate of Covid-19. Cardiovascular diseases, cancer, and non-communicable diseases were still more lethal and caused more deaths than Covid-19.

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First Cases of Coronavirus Disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020

Cited by 179 publications

References 1 publication

COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis

COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis

ENT emergencies during the first wave of COVID-19 pandemic in Spain: Our experience

A Normalized Mortality Rate Showed the Diverse Severity of COVID-19 and Its Association With Other Chronic Diseases

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