First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020

Spiteri, Gianfranco; Fielding, James E; Diercke, Michaela; Campese, C; Enouf, Vincent; Gaymard, Alexandre; Bella, Antonino; Sognamiglio, Paola; Moros, María José Sierra; Riutort, Antonio Nicolau; Demina, Yulia V.; Mahieu, Romain; Broas, Markku; Bengnér, Malin; Buda, Silke; Schilling, Julia; Filleul, Laurent; Lepoutre, A.; Saura, C.; Mailles, Alexandra; Lévy-Brühl, Daniel; Coignard, B.; Bernard-Stoecklin, Sibylle; Behillil, Sylvie; Werf, Sylvie van der; Valette, Martine; Lina, Bruno; Riccardo, Flavia; Nicastri, Emanuele; Casas, Inmaculada; Larrauri, Amparo; Castell, Magdalena Salom; Pozo, Francisco; Maksyutov, Rinat А.; Martin, Charlotte; Ranst, Marc Van; Bossuyt, Nathalie; Siira, Lotta; Sane, Jussi; Tegmark-Wisell, Karin; Palmérus, Maria; Broberg, Eeva; Beauté, Julien; Jorgensen, Pernille; Bundle, Nick; Pereyaslov, Dmitriy; Adlhoch, Cornelia; Pukkila, Jukka; Pebody, Richard; Olsen, Sonja J.; Ciancio, Bruno Christian

doi:10.2807/1560-7917.es.2020.25.9.2000178

Cited by 484 publications

(330 citation statements)

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“…15 In the first report of COVID-19 from the WHO European Region, a low frequency of gastrointestinal symptoms was also found. 14 In contrast, among 140 cases also from Wuhan, Zhang J-J et al, reported a higher frequency (39.6%) of gastrointestinal symptoms. In their series, nausea was the most common symptom while the frequency of diarrhea was very similar (12.9%).…”

Section: Resultsmentioning

confidence: 94%

“…[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Thirteen papers were from China, 5-13, 15-17, 19 one from Singapore, 18 and one from the World Health Organization European Region. 14 (Table 1) These papers analyzed a total of 2800 patients. Of them 210 (7.5%) reported diarrhea, 125 (4.5%) nausea, 124 (4.4%) anorexia, 15 (0.5%) abdominal pain, 9 (0.3%) belching and reflux, and 7 (0.25%) patients from one study reported a combination of different symptoms (i.e.…”

Section: Resultsmentioning

confidence: 99%

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Alerta: los síntomas gastrointestinales podrían ser una manifestación de la COVID-19

Schmulson¹,

Dávalos²,

Berúmen³

2020

Revista de Gastroenterología de México

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Alerta: los síntomas gastrointestinales podrían ser una manifestación de la COVID-19

Schmulson¹,

Dávalos²,

Berúmen³

2020

Revista de Gastroenterología de México

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“…Case fatality rates (CFR), not accounting for delays, were calculated by age and sex and smoothed with the locally weighted regression method. CFRs by age were also calculated by calendar period of diagnosis (i.e., before 4 th , [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. A multilevel (clustered by Region/AP) multivariable logistic model was applied to evaluate characteristics associated with death, including age group (i.e., ≤40, 40-49, 50-59, 60-69, 70-79, 80-89, 90+ years), sex, HCW status, and week of diagnosis.…”

Section: Resultsmentioning

confidence: 99%

“…With the aim to increase the understanding of the disease dynamics in Italy and support the planning of public health actions, a case-based surveillance system was established on the 27 th of February 2020, building on a previously existing surveillance system focused only on suspected and confirmed COVID-19 severe respiratory infections (12). The system contains data on all laboratory confirmed cases of COVID-19 as per the case definition published and regularly updated online by the European Centre for Disease Prevention and Control (ECDC) (13).…”

Section: The Italian Integrated Covid-19 Surveillance Systemmentioning

confidence: 99%

Epidemiological characteristics of COVID-19 cases in Italy and estimates of the reproductive numbers one month into the epidemic

Riccardo

Ajelli

Andrianou

et al. 2020

Preprint

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Background In February 2020, a locally-acquired COVID-19 case was detected in Lombardia, Italy. This was the first signal of ongoing transmission of SARS-CoV-2 in the country. The outbreak rapidly escalated to a national level epidemic, amid the WHO declaration of a pandemic. MethodsWe analysed data from the national case-based integrated surveillance system of all RT-PCR confirmed COVID-19 infections as of March 24 th 2020, collected from all Italian regions and autonomous provinces. Here we provide a descriptive epidemiological summary on the first 62,843 COVID-19 cases in Italy as well as estimates of the basic and net reproductive numbers by region.Findings Of the 62,843 cases of COVID-19 analysed, 71·6% were reported from three Regions (Lombardia, Veneto and Emilia-Romagna). All cases reported after February 20 th were locally acquired. Estimates of R0 varied between 2·5 (95%CI: 2·18-2·83) in Toscana and 3 (95%CI: 2·68-3·33) in Lazio, with epidemic doubling time of 3·2 days (95%CI: 2·3-5·2) and 2.9 days (95%CI: 2·2-4·3), respectively. The net reproduction number showed a decreasing trend starting around February 20-25, 2020 in Northern regions. Notably, 5,760 cases were reported among health care workers. Of the 5,541 reported COVID-19 associated deaths, 49% occurred in people aged 80 years or above with an overall crude CFR of 8·8%. Male sex and age were independent risk factors for COVID-19 death.Interpretation The COVID-19 infection in Italy emerged with a clustering onset similar to the one described in Wuhan, China and likewise showed worse outcomes in older males with comorbidities. Initial R0 at 2·96 in Lombardia, explains the high case-load and rapid geographical spread observed. Overall Rt in Italian regions is currently decreasing albeit with large diversities across the country, supporting the importance of combined non-pharmacological control measures.Funding: routine institutional funding was used to perform this work.

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“…The analysis of the first 7,755 cases of COVID-19 in Korea showed a first increase of cases in specific geographic region comparable to the epidemiological situation in China and Italy (4,5). In Korea, despite a relevant number of cases per week in late February and early March, the peak seemed to have levelled off, yet the first wave did not go away.…”

Section: Discussionmentioning

confidence: 71%

Coronavirus disease-19: The First 7,755 Cases in the Republic of Korea

Choe

2020

Preprint

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We report the first 7,755 patients with confirmed COVID-19 in Korea as of March 13, 2020. A total of 66 deaths were identified, resulting case fatality proportion of 0.9%. Older people, and those with coexisting medical conditions were at risk for fatal outcomes. The highest number of cases were from Daegu, followed by Gyeongbuk, with elevated age-stratified case fatality.This summary may help to understand the disease dynamics in the early phase of COVID-19 outbreak, therefore, to guide future public health measures.

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First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020

Cited by 484 publications

References 5 publications

Alerta: los síntomas gastrointestinales podrían ser una manifestación de la COVID-19

Alerta: los síntomas gastrointestinales podrían ser una manifestación de la COVID-19

Epidemiological characteristics of COVID-19 cases in Italy and estimates of the reproductive numbers one month into the epidemic

Coronavirus disease-19: The First 7,755 Cases in the Republic of Korea

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