First complete genomic characterization of a porcine parvovirus 5 isolate from China

Wu, Rui; Wen, Yiping; Huang, Xiaobo; Wen, Xintian; Yan, Qiguai; Huang, Yong; Ma, Xiaoping; Cao, Sanjie

doi:10.1007/s00705-013-1948-4

Cited by 16 publications

(16 citation statements)

References 20 publications

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“…PPV5 and PPV6 represent very recently identified PPV genotypes in China and the USA (Xiao et al., ; Ni et al., ; Wu et al., ; Schirtzinger et al., ), but knowledge of their circulating in Europe is still limited (Cui et al., ; Fan et al., ). In Poland, the overall prevalence rate of PPV5 was only 4.0%.…”

Section: Discussionmentioning

confidence: 99%

“…PPV4, which in contrast to other pig parvoviruses possesses an additional ORF3, was identified in pigs coinfected with PCV2 in 2010 (Cheung et al., ). In 2013 and 2014, PPV5 and PPV6 have been discovered in China and North America (Xiao et al., ; Ni et al., ; Wu et al., ; Schirtzinger et al., ). PPV4, PPV5 and PPV6 are closely related and form a distinct branch based on phylogenetic analysis (Ni et al., ; Schirtzinger et al., ).…”

Section: Introductionmentioning

confidence: 99%

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Circulation of Porcine Parvovirus Types 1 through 6 in Serum Samples Obtained from Six Commercial Polish Pig Farms

Cui

Biernacka

Fan

et al. 2016

Transbound Emerg Dis

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Porcine parvoviruses are small non-enveloped DNA viruses, very resistant to inactivation, and ubiquitous in the global pig population. Porcine parvovirus type 1 (PPV1) has been known since the 1960s and is a major causative agent of reproductive failure in breeding herds. During the last decade, several new parvoviruses have been identified in pigs by molecular methods and have been consecutively designated as PPV2 through PPV6. Epidemiology data for these viruses are limited, and the impact of these newly recognized parvoviruses on pigs is largely unknown. To further generate knowledge on the distribution of PPVs in pigs, a total of 247 serum samples were collected from six commercial Polish pig farms during 2013-2015 and tested by PCR assays and ELISAs. The pigs ranged from two to 18 weeks of age at sample collection. Breeding herds supplying the investigated farms were routinely vaccinated against PPV1. While all growing pig samples were negative for PPV1 DNA, young pigs were frequently negative for PPV1 antibodies and seroconversion to PPV1 was commonly seen at 9-10 weeks of age. The PPV2 antibody detection was highest in young pigs (2-6-week-old) and decreased in older pigs indicating passively acquired antibodies. The DNA prevalence rates in the serum samples analysed were 19% for PPV2, 7.7% for PPV3, 2.4% for PPV4, 4.0% for PPV5 and 6.1% for PPV6. Most PPV DNA-positive samples were identified in 9- to 18-week-old pigs with no obvious association with disease on the farm. All recently emerging PPV genotypes were detected in Polish farms. Similar to previous reports in other pig populations, PPV2 was the most frequent PPV genotype circulating in Poland.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circulation of Porcine Parvovirus Types 1 through 6 in Serum Samples Obtained from Six Commercial Polish Pig Farms

Cui

Biernacka

Fan

et al. 2016

Transbound Emerg Dis

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“…PPV was first isolated from pigs with fever in 1965 [4]. It is commonly found in diseased pigs and is the cause of significant economic loss for the swine industry today [1,[5][6][7][8][9]. Currently, vaccination is the primary measure for prevention of PPV.…”

Section: Introductionmentioning

confidence: 99%

Antiviral effect of lithium chloride on infection of cells by porcine parvovirus

et al. 2015

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Porcine parvovirus (PPV) causes reproductive failure in pigs, which leads to economic losses to the industry. As reported previously, LiCl efficiently impairs the replication of a variety of viruses, including the coronavirus infectious bronchitis virus (IBV), transmissible gastroenteritis virus (TGEV), and pseudorabies herpesvirus. We demonstrate for the first time that inhibition of PPV replication in swine testis (ST) cells by LiCl is dose-dependent, and that the antiviral effect of LiCl occurred in the early phase of PPV replication. These results indicate that LiCl might be an effective anti-PPV drug to control PPV disease. Further studies are required to explore the mechanism of the antiviral effect of LiCl on PPV infection in vivo.

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“…Unlike PPV1, these new emerging parvoviruses in pigs belong to one of the two new genera, Tetraparvovirus (PPV2 and PPV3) and Copiparvovirus (PPV4, PPV5, and PPV6). PPV5, initially detected mainly in grow-finish pigs in the United States in 2013 (4, 5) and subsequently also identified in China in 2014 (6), is most closely related to PPV4, with an overall genome similarity of 64.1% to 67.3%. Unlike PPV4, which has an additional open reading frame 3 (ORF3), PPV5 like other PPV strains has two ORFs.…”

Section: Genome Announcementmentioning

confidence: 99%

First Genome Sequences of Porcine Parvovirus 5 Strains Identified in Polish Pigs

et al. 2016

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First complete genomic characterization of a porcine parvovirus 5 isolate from China

Cited by 16 publications

References 20 publications

Circulation of Porcine Parvovirus Types 1 through 6 in Serum Samples Obtained from Six Commercial Polish Pig Farms

Circulation of Porcine Parvovirus Types 1 through 6 in Serum Samples Obtained from Six Commercial Polish Pig Farms

Antiviral effect of lithium chloride on infection of cells by porcine parvovirus

First Genome Sequences of Porcine Parvovirus 5 Strains Identified in Polish Pigs

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