First-degree atrioventricular block in 14-year-old child due to Lyme disease

Lytvyn, Halyna; Basa, Natella; Slivinska-Kurchak, Khrystyna; Avramenko, Iryna

doi:10.3855/jidc.15071

Cited by 3 publications

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“…Як правило, на момент звернення, пацієнти з бореліозною лімфоцитомою є серопозитивними. Бореліозна лімфоцитома часто реєструється у пацієнтів з Європи, проте, дуже рідко трапляється у США [4,5].…”

Section: вступunclassified

Borrelial Lymphocytoma in a Child. Clinical Case

Lytvyn,

Nadragа,

Zinchuk

et al. 2024

Buk. Med. Herald

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Lyme borreliosis is a multisystem infectious disease caused by bacteria of the Borrelia burgdorferi sensu lato complex.The course of the disease is characterized by three stages: early localized, early disseminated and late disseminated. One of the rare forms of the early disseminated stage of Lyme disease in children is lymphocytoma.We present a clinical case of borrelial lymphocytoma caused by a combination of three types of Borrelia (Borrelia afzelii, Borrelia burgdorferi, Borrelia garinii) in a 6-year-old girl. The disease manifested as multiple migratory erythema on the child's face, mistaken for allergic dermatitis. According to the parents, the child had no history of tick bites. The diagnosis was confirmed by the ELISA method and immunoblot analysis. The patient was prescribed a 21-day course of doxycycline at 50 mg twice daily. Three weeks after the initiation of antibiotic therapy, complete regression of the lymphocytoma was observed. The purpose of the study is to draw the attention of doctors of various specialties to rare forms of Lyme borreliosis against the background of the absence of a verified fact of tick bite.Material and methods. Confirmation of the diagnosis by ELISA and immunoblot analysis.Research results. A clinical case of borrelial lymphocytoma caused by a combination of three Borrelia species (Borrelia afzelii, Borrelia burgdorferi, Borrelia garinii) in a 6-year-old girl is presented. The disease manifested as multiple migratory erythema in the area of the child's face, which was mistaken for allergic dermatitis. According to the parents, the child had no history of a tick bite. The diagnosis was confirmed by ELISA and immunoblot analysis. The patient was prescribed doxycycline treatment for 21 days at 50 mg twice a day. Three weeks after the start of antibiotic therapy, a complete regression of the lymphocytoma was observed.Conclusions. Doctors of various specialties have difficulties in diagnosing Lyme disease in its various stages, especially in children with a heavy allergic history. With the presented clinical case, we want to emphasize the importance of early and timely diagnosis of Lyme borreliosis, in particular, in the absence of an episode of tick bite in the anamnesis.

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Section: вступunclassified

Borrelial Lymphocytoma in a Child. Clinical Case

Lytvyn,

Nadragа,

Zinchuk

et al. 2024

Buk. Med. Herald

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“…Çà ð³âíåì çàõâîðþâàíîñò³ ³ ïîøèðåíîñò³, âàaeê³ñòþ êë³í³÷íèõ ïðîÿâ³â, ÷àñòèì ïåðåõîäîì äî ðåöèäèâíîãî ³ çàòÿaeíîãî ïåðåá³ãó Ëàéì-áîðåë³îç (ËÁ) º îäí³ºþ ç íàé-á³ëüø àêòóàëüíèõ ïðîáëåì ñó÷àñíî¿ ³íôåêö³é-íî¿ ïàòîëîã³¿ Ï³âí³÷íî¿ Àìåðèêè, Àç³¿ ³ áàãàòüîõ êðà¿í ªâðîïè [2]. Íà äàíèé ÷àñ â³äáóâàºòüñÿ çá³ëüøåííÿ ÷èñåëüíîñò³ ³ ê³ëüêîñò³ êë³-ù³â ³íô³êîâàíèõ áîðåë³ÿìè, ùî â ñâîþ ÷åðãó ïðèçâîäèòü äî çá³ëüøåííÿ ê³ëüêîñò³ ³íô³êîâàíèõ ä³òåé [3].…”

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“…In terms of the level of morbidity and prevalence, the severity of clinical manifestations, and the frequent transition to a recurrent and protracted course, Lyme borreliosis (LB) is one of the most relevant problems in contemporary infectious pathology in North America, Asia, and many European countries [2]. At present, there is an increase in the number and quantity of ticks infected with Borrelia, leading to an increase in the number of infected children [3].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Laboratory Features of Lyme Arthritis and Arthritides of Other Etiologies in Children of Lviv Region

Lytvyn,

Basa

2023

AML

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Introduction. Lyme disease is one of the most common transmissible infections, which is characterized by the predominant damage to the skin, cardiovascular system, nervous system, and musculoskeletal system. Lyme arthritis is almost twice as common in children as in adults, and is the most common manifestation of late-stage Lyme disease without the presence of erythema migrans. Aim. To study and analyze the clinical and laboratory features of Lyme arthritis and arthritides of other etiology. Materials and Methods. A total of 16 children under observation applied to the "Lviv Regional Infectious Disease Clinical Hospital" with suspicion of Lyme arthritis. ELISA and immunoblot to B.burgorferi, complete blood count, C-reactive protein, interleukin-6, and creatine phosphokinase-MB were used to identify the cause of the joint syndrome. Results and Discussion. The participants were subdivided into 2 clinical groups: the first included patients with suspicion of Lyme arthritis, while the second consisted of children with confirmed Lyme arthritis. In group 1, boys comprised 66.7%, and in group 2 - 42.9%. Conversely, girls accounted for 33.3% and 57.1% of the respective groups. CRP was found to be four times higher in patients from group 2, reaching 16.9 mg/l, whereas in patients from group 1, it was 4.0 mg/l. The IL-6 level was observed to be <1.5 pg/ml more frequently (in 71.4% of cases) in group 2 compared to clinical group 1, where the proportion of patients with such levels of this indicator was 44.4%. None of our patients in group 2 and only 1 patient in group 1 (11.1%) had an IgM level <2 IU/ml. Significantly (p=0.02) higher levels of IgG >200 IU/ml were more often found in group 2, where the percentage of such patients was 42.9%, while in group 1, IgG was not detected in any of the patients. Conclusions. The cause of Lyme arthritis in children is a combination of several types of Borrelia. The laboratory criterion for Lyme arthritis is positive IgG to B. burgdorferi in enzyme immunoassays and immunoblot analyses. Significantly (p=0.02) higher levels of IgG >200 IU/ml were more often found in 42.9% of patients with Lyme arthritis. To identify the causes of joint syndrome in children, in the absence of a history of tick bites and erythema migrans, a two-stage method for diagnosing Lyme arthritis is necessary.

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Частота І Клінічні Прояви Уражень Серцево-Судинної Системи При Лайм-Бореліозі

Андрейчин,

Бількевич,

Кавецька

2024

ІХ

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Проаналізовано дані наукової літератури щодо епідеміології уражень серця при Лайм-бореліозі (ЛБ), розглянуто патогенез цих уражень; частоту, терміни виникнення та клінічне значення кардіологічних симптомів цієї недуги. Акцентовано увагу на причинах труднощів клінічної діагностики Лайм-кардиту на сучасному етапі. Зазначено, що актуальність ЛБ не зменшується, незважаючи на успіхи в лікуванні, а у ряді країн продовжує зростати, що зумовлено кліматичними змінами та іншими факторами. Детально описано зміни, які виникають у період ранньої дисемінації збудника. Зокрема досліджено такий потенційно життєво загрозливий стан як атріовентрикулярна блокада (AV-блокада). Аналізуються повідомлення про синдром слабкості синусового вузла, синоатріальну блокаду, а також порушення ритму серця. Ряд клінічних аспектів ЛБ потребують глибшого вивчення. Це стосується міокардиту та перикардиту борелійної етіології, які часто перебігають малосимптомно. Найменш вивченими є кардіологічні ускладнення у хронічній стадії ЛБ, про які є лише поодинокі повідомлення. Потребує подальших досліджень питання діагностики міокардиту та пізніх уражень серця при ЛБ, необхідне встановлення чітких діагностичних критеріїв таких уражень. В ендемічних щодо ЛБ регіонах потрібна настороженість щодо можливості борелійної етіології уражень серця не лише у разі AV-блокади, а й інших порушень ритму та провідності.

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First-degree atrioventricular block in 14-year-old child due to Lyme disease

Cited by 3 publications

References 0 publications

Borrelial Lymphocytoma in a Child. Clinical Case

Borrelial Lymphocytoma in a Child. Clinical Case

Clinical and Laboratory Features of Lyme Arthritis and Arthritides of Other Etiologies in Children of Lviv Region

Частота І Клінічні Прояви Уражень Серцево-Судинної Системи При Лайм-Бореліозі

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