2015
DOI: 10.1371/journal.pntd.0003986
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First Documented Transmission of Trypanosoma cruzi Infection through Blood Transfusion in a Child with Sickle-Cell Disease in Belgium

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Cited by 18 publications
(17 citation statements)
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“…Explanations provided for this apparent discrepancy in transmission rates include a parasite predilection for platelet (PLT) products, chronologically remote infection among seropositive donors, and asymptomatic infections with low to intermittent parasitemia, but none of these provide a clear and compelling answer. While most transmission cases have implicated PLT products, a recently published case from Belgium indicates that red blood cells (RBCs) may also play a role, albeit limited . The observation that Spain has reported higher relative rates of transfusion transmission than the United States suggests the need to examine alternative explanations .…”
mentioning
confidence: 99%
“…Explanations provided for this apparent discrepancy in transmission rates include a parasite predilection for platelet (PLT) products, chronologically remote infection among seropositive donors, and asymptomatic infections with low to intermittent parasitemia, but none of these provide a clear and compelling answer. While most transmission cases have implicated PLT products, a recently published case from Belgium indicates that red blood cells (RBCs) may also play a role, albeit limited . The observation that Spain has reported higher relative rates of transfusion transmission than the United States suggests the need to examine alternative explanations .…”
mentioning
confidence: 99%
“…In our results, RBCs had the second highest concentration of parasites and would therefore carry a high risk of transfusion transmission of Chagas disease if not leukoreduced. The first published case of transmission of T. cruzi infection through RBC transfusion occurred recently in Belgium, involving a boy with sickle cell disease . However, the authors did not mention in their article whether or not the transfused RBCs had been leukoreduced or, if so, whether it was pre‐ or poststorage filtration.…”
Section: Discussionmentioning
confidence: 99%
“…8 Recently, a case of transfusion transmission involving red blood cells (RBCs) has been described. 9 The development of sensitive and specific molecular tools based on polymerase chain reaction (PCR) methods has improved the detection of T. cruzi, with regard to less sensitive methods like direct detection or parasite culture. 10 Real-time PCR is a relatively new technology that allows the parasite load in a sample to be quantified in a specific manner.…”
Section: Discussionmentioning
confidence: 99%
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