First evaluation of drug-in-cyclodextrin-in-liposomes as an encapsulating system for nerolidol

Azzi, Joyce; Auezova, Lizette; Danjou, Pierre-Edouard; Fourmentin, Sophie; Greige‐Gerges, Hélène

doi:10.1016/j.foodchem.2018.02.055

Cited by 58 publications

(45 citation statements)

References 39 publications

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“…The initial burst release in the first 8 hr can be related to phenolic compounds entrapped in the external monolayer of the membrane, which can be released more quickly from nanoliposomes (Azzi, Auezova, Danjou, Fourmentin, & Greige-Gerges, 2018). The initial burst release in the first 8 hr can be related to phenolic compounds entrapped in the external monolayer of the membrane, which can be released more quickly from nanoliposomes (Azzi, Auezova, Danjou, Fourmentin, & Greige-Gerges, 2018).…”

Section: In Vitro Releasementioning

confidence: 99%

Manufacturing of nanoliposomal extract from Sargassum boveanum algae and investigating its release behavior and antioxidant activity

Savaghebi

Barzegar

Mozafari

2019

Food Science & Nutrition

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In this paper, the fabrication of algal extract-loaded nanoliposomes was optimized based on the central composite response surface design. Different concentrations of phenolic compounds (500, 1,000, and 1,500 ppm) of algal extract and lecithin (0.5, 1.25, and 2% w/w) were applied for preparation of nanoliposomes at process temperatures of 30, 50, and 70°C. Dependent variables were zeta potential, entrapment efficiency, size, and particle size distribution. The particle size of the loaded nanoliposomes ranged from 86.6 to 118.7 nm and zeta potential from −37.3 to −50.7 mV.The optimal conditions were as follows: 0.5% lecithin, 30°C process temperature, and 1,313 ppm of the phenolic compounds extracted from algae. Under these conditions, the experimental entrapment efficiency of the phenolic compounds was 45.5 ± 1.2%. FTIR analysis has verified the encapsulation of algal extract in nanoliposomes. Algal extract phenolic compounds also increased phase transition temperature (Tc) of nanoliposomes (1.6°C to 6.3°C). Moreover, the thermo-oxidative protection of nanoliposomes for the algal extract has been proved by examining the DSC thermograms.It has been demonstrated that the formulated nanoliposomes have a good stability during storage conditions, and they are able to control the release of phenolic compounds at different pH values. During the encapsulation process, the antioxidant activity of the algal extract has been maintained to an acceptable level. Consequently, algal extract-loaded nanoliposomes can be used as a natural antioxidant in lipidbased foods. K E Y W O R D Salgal extract, antioxidant, encapsulation, nanoliposome, polyphenols 300 |

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Section: In Vitro Releasementioning

confidence: 99%

Manufacturing of nanoliposomal extract from Sargassum boveanum algae and investigating its release behavior and antioxidant activity

Savaghebi

Barzegar

Mozafari

2019

Food Science & Nutrition

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“…DCL–DL is also being investigated for loading substances to be used as additives for providing the photoprotection and preservation of essential oils [26] or food nutraceuticals [27,28].…”

Section: Introductionmentioning

confidence: 99%

Novel Findings about Double-Loaded Curcumin-in-HPβcyclodextrin-in Liposomes: Effects on the Lipid Bilayer and Drug Release

et al. 2018

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In this study, the encapsulation of curcumin (Cur) in “drug-in-cyclodextrin-in-liposomes (DCL)” by following the double-loading technique (DL) was proposed, giving rise to DCL–DL. The aim was to analyze the effect of cyclodextrin (CD) on the physicochemical, stability, and drug-release properties of liposomes. After selecting didodecyldimethylammonium bromide (DDAB) as the cationic lipid, DCL–DL was formulated by adding 2-hydroxypropyl-α/β/γ-CD (HPβCD)–Cur complexes into the aqueous phase. A competitive effect of cholesterol (Cho) for the CD cavity was found, so cholesteryl hemisuccinate (Chems) was used. The optimal composition of the DCL–DL bilayer was obtained by applying Taguchi methodology and regression analysis. Vesicles showed a lower drug encapsulation efficiency compared to conventional liposomes (CL) and CL containing HPβCD in the aqueous phase. However, the presence of HPβCD significantly increased vesicle deformability and Cur antioxidant activity over time. In addition, drug release profiles showed a sustained release after an initial burst effect, fitting to the Korsmeyer-Peppas kinetic model. Moreover, a direct correlation between the area under the curve (AUC) of dissolution profiles and flexibility of liposomes was obtained. It can be concluded that these “drug-in-cyclodextrin-in-deformable” liposomes in the presence of HPβCD may be a promising carrier for increasing the entrapment efficiency and stability of Cur without compromising the integrity of the liposome bilayer.

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“…The average size of liposomal nerolidol was 132.3 nm, which is in accordance with the standard values reported in the literature [ 44 , 45 , 46 ]. Nevertheless, according to Azzi et al [ 20 ], the variations in the size of liposomal vesicles may occur due to changes in the arrangement of lipids induced by the incorporated substance.…”

Section: Discussionmentioning

confidence: 99%

“…In this context, our group has recently demonstrated that the incorporation of nerolidol into carrier nanoparticles, including liposomes, improved its physicochemical characteristics, which could result in improved biopharmaceutical properties [ 20 ]. Accordingly, studies have shown that liposomes can increase absorption, improve distribution, and prolong biological half-lives, thus improving the therapeutic index of several drugs [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole

et al. 2020

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(1) Background: Infections by Candida species represent a serious threat to the health of immunocompromised individuals. Evidence has indicated that nerolidol has significant antifungal properties. Nonetheless, its use is restricted due to a low water solubility and high photosensitivity. The incorporation into liposomes may represent an efficient alternative to improve the physicochemical and biopharmaceutical properties of this compound. The present study aimed to characterize the antifungal properties of liposomal nerolidol, alone or in combination with fluconazole. Of note, this is the first study reporting the antifungal activity of liposomal nerolidol and its potentiating effect in association with fluconazole. (2) Methods: The Inhibitory Concentration 50%-IC50 and minimum fungicide concentrations (MFC) of the substances against Candida albicans (CA), Candida tropicalis (CT), and Candida krusei (CK) were established by subculture in a solid medium. To evaluate the antifungal-enhancing effect, the MFC of fluconazole was determined in the presence or absence of subinhibitory concentrations of nerolidol (free or liposomal). The analysis of fungal dimorphism was performed through optical microscopy and the characterization of liposomes was carried out considering the vesicular size, polydispersion index, and zeta medium potential, in addition to a scanning electron microscopy analysis. (3) Results: The physicochemical characterization revealed that liposomes were obtained as homogenous populations of spherical vesicles. The data obtained in the present study indicate that nerolidol acts as an antifungal agent against Candida albicans and Candida tropicalis, in addition to potentiating (only in the liposomal form) the effect of fluconazole. However, the compound had little inhibitory effect on fungal dimorphism. (4) Conclusions: The incorporation of nerolidol into liposomes improved its antifungal-modulating properties.

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First evaluation of drug-in-cyclodextrin-in-liposomes as an encapsulating system for nerolidol

Cited by 58 publications

References 39 publications

Manufacturing of nanoliposomal extract from Sargassum boveanum algae and investigating its release behavior and antioxidant activity

Manufacturing of nanoliposomal extract from Sargassum boveanum algae and investigating its release behavior and antioxidant activity

Novel Findings about Double-Loaded Curcumin-in-HPβcyclodextrin-in Liposomes: Effects on the Lipid Bilayer and Drug Release

Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole

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