First Evidence of Polymorphism in Furosemide Solvates

Abstract

Several polymorphs of solvates of furosemide with dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) have been obtained, and their crystal structures were solved and analyzed. The structures differ from each other in both conformation of the furosemide molecule (particularly with respect to the orientation of the furanylmethylamino fragment) and molecular packing. The arrangement of solvent molecules—DMSO and DMF—is different in different polymorphs: either in the channels or between the layers. Layered polymorphs can be formed on rapid crystallization using water as an antisolvent, whereas a slower crystallization on evaporation promotes the growth of channeled structures. Despite different crystal structures, F-DMSO-I, F-DMSO-II, F-DMSO-III, and F-DMF-II give the same phase on desolvation, namely, furosemide polymorph I, which is the thermodynamic form at ambient conditions

Solvates of acotiamide hydrochloride: characterization and phase transformation

“…DMF and DMSO are usually employed as crystallization solvents. These two solvents generally interact with APIs only as classic hydrogen-bond acceptors in crystals (Brychczynska et al, 2012;Beloborodova et al, 2017). Thus, AH may interact with DMF or DMSO via a novel interaction mode if it forms solvates with DMF and DMSO.…”

Development and Structure Analysis of Crystal Forms of Apabetalone: Solvates and Polymorphs

“…Polymorphism, which refers to different arrangements or conformations of the same molecules in the crystal structure, is a common phenomenon widely observed in the preparation and storage process of organic crystals. , Different crystal forms have different properties, − which significantly influence the quality and efficacy of the final product. Aspirin and paracetamol, for instance, are representative of widely used pharmaceuticals, and their newly discovered forms improved tableting (lowering production costs) and bioavailability. , Therefore, the research on polymorphs is of critical importance to help us find the desired crystal form with excellent performance. − …”

A Combined Crystallographic and Computational Study on Dexketoprofen Trometamol Dihydrate Salt

“…X-ray crystallography is the key to studying structure-property relationships and single crystal X-ray diffraction (SCXRD) is the method of choice for molecular and crystal structure determination when crystals are available, as well as X-ray powder diffraction (XRPD), which provides an alternative valuable tool for the characterization of crystalline powder materials [10]. Both of these techniques [11][12][13][14][15], complemented by differential scanning calorimetry [16][17][18], solid state NMR [19], IR-UV and Raman spectroscopy [20][21][22] and modelling [23][24][25][26][27][28][29], can be successfully used to characterize the solid state features and behavior (e.g., phase stability, polymorphism, phase transformation) of a large variety of compounds including APIs' key precursors, well-known APIs as well as new promising active pharmaceutical compounds.…”