First evidence of toxin production by bacteria in a marine organism.

Kosuge, Takuo; Tsuji, Kiichiro; Hirai, Koichi; Fukuyama, Toshinori

doi:10.1248/cpb.33.3059

Cited by 43 publications

(19 citation statements)

References 5 publications

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“…The fungal strain was cultured in a mediumcontaining glucose, peptone and yeast extract in artifical seawater. The MeOHextract of the mycelium was purified by bioassay-directed fractionation employing a combination of Sephadex LH-20 and silica gel column chromatographies and HPLCto afford leptosins I (2) and J (3).…”

Section: Resultsmentioning

confidence: 99%

Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures.

et al. 1994

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Section: Resultsmentioning

confidence: 99%

Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures.

et al. 1994

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“…This is the first report on the production of organic iodine other than iodomethane by marine bacteria, although there have been some previous reports on the production of organic bromine, including pentabromopseudiline and neosurugatoxin, by marine bacteria [35,36]. Further study of the mechanism of iodination and the distribution of iodinating bacteria in the ocean will provide useful insight into the global circulation of iodine.…”

Section: Resultsmentioning

confidence: 85%

Production of free and organic iodine byRoseovariusspp.

Fuse

Inoue

Murakami

et al. 2003

FEMS Microbiology Letters

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Two strains of iodine-producing bacteria were isolated from marine samples. 16S rRNA gene sequences indicated the strains were most closely related to Roseovarius tolerans, and phylogenetic analysis indicated both belong to the same genus. 5 mM iodide inhibited the growth of strain 2S5-2 almost completely, and of strain S6V slightly. Both strains produced free iodine and organic iodine from iodide. CH 2 I 2 , CHI 3 and CH 2 ClI were the main organic iodines produced by strain 2S5-2, and CHI 3 and CH 2 I 2 by strain S6V. Experiments using cells and spent media suggested that the organic iodines were produced from the compounds released or contained in the media and cells were necessary for the considerable production of CH 2 I 2 and CH 2 ClI, though CHI 3 was produced by spent media with H 2 O 2 or free iodine. ß

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“…Evidence of bacterial toxin production was first obtained for the interesting, but not widespread toxin neosurugatoxin (35). First found along with prosurugatoxin as an unexpected toxicant in the edible Japanese mollusk, Babylonia japonica (Kosuge et al, 1972), this unique toxin was later traced to an unexpected source, a Gram-positive, coryneform bacterium isolated directly from the digestive gland of the animal (Kosuge et al, 1985). It appears that environmental conditions were generated which allowed this bacterium to attain large numbers in Babylonia.…”

Section: Symbiotic Marine Bacteria-origins Of Marine Toxinsmentioning

confidence: 99%