Objective: To find out the outcome of intermittent Kangaroo Mother Care KMC) in terms of weight-gain among low birth weight (LBW) neonates in Neonatal Intensive Care Unit (NICU). Study Design: A randomized controlled trial. Place and Duration of the Study: This study was conducted at Department of Pediatrics Gulab Devi Hospital, Lahore from March 2020 to February 2021. Methodology: A total of 226 (113 KMC Group and 113 controls) neonates of both genders with birth weight between 1500 grams to 2499 grams admitted to NICU with their mothers available for KMC application were enrolled. KMC Groups received KMC whereas controls were given conventional care. KMC was started from 8th post-natal day and a separate block of NICU was dedicated for the implementation of KMC. Body weight of all the neonates was measured from day-zero (8th post-natal day) up to day-7 (15th post-natal day). Results: Out of a total of 226 neonates, 121 (53.5%) were boys and 105 (46.5%) girls, Overall, mean gestational age was calculated to be 34.8±2.6 weeks. Most frequent main diagnosis at the time of admission was pneumonia, 64 (28.3%) neonates. Mean body weight was significantly increased among neonates of KMC Group in comparison to control at day-4, day-6 and day-7 (p<0.05). Total weight gain from day-0 to day-7 was found to be 0.24±0.1 kg in KMC groups and 0.15±0.1 kg among controls (p<0.0001). Mean duration of hospital stay was noted to be 17.5±2.9 days in KMC Group versus 20.7±3.4 days among controls (p<0.0001). Conclusion: In comparison to conventional care, intermittent KMC was found to significantly more effective in terms of improvement in weight gain and reduction in duration of hospitalization. Keywords: Exclusive breast-feeding, Kangaroo mother care, neonatal intensive care unit, pneumonia.