First-in-class and best-in-class dendrimer nanoplatforms from concept to clinic: Lessons learned moving forward

Poly(amidoamine) Dendrimers as Nanocarriers for 5-Fluorouracil: Effectiveness of Complex Formation and Cytotoxicity Studies

“…Despite their unique properties, dendrimers have not yet been implemented into medical practice on a larger scale. The first marketed product based on dendrimers is Vivagel ® , an antiviral and antibacterial agent developed by pharmaceutical company Starpharma Ltd. [ 13 ]. The implementation of a dendrimer-based product into clinical practice proves their practical applicability.…”

First-in-Class Phosphorus Dendritic Framework, a Wide Surface Functional Group Palette Bringing Noteworthy Anti-Cancer and Anti-Tuberculosis Activities: What Lessons to Learn?

“…The advantages of low-generation phosphorus dendrimers and dendrons should be as follows: few chemical steps leading to G0 in high overall yield; high water solubility; strong chemical stability for more than 1 year; ability to be prepared under good manufacturing conditions in large quantities; ease of modifying the nature and the number of terminal groups to build diverse libraries; and cheap starting materials. An important part of our research was the use of phenotypic screening as a powerful tool for identifying new active chemical entities, in our case phosphorus dendrimers and dendrons, with an original mechanism of action reinforcing the concept of chemical space availability by the increase of affinity and selectivity towards their respective targets [ 49 ] using, for instance, dendrimers and dendrons (and biologics) versus small molecules or peptides [ 23 ]. In a nutshell, phosphorus dendrimers and dendrons, active per se, present a new strategy for the medicinal chemist in the development of new drugs, with much research still to be done and fundamental tenets to be discovered.…”

“…As advocated by Frechet and Szoka et al [ 18 ] and Khandare and Haag et al [ 19 ], the success of dendrimers in nanomedicine, both as nanocarriers and as drugs, is strongly related to their in vivo biocompatibility. The challenges and limitations during active research development, such as clinical translation factors and the challenge of current dogmas of carefully assembled dendrimers as first-in-class and best-in-class, were recently emphasized [ 20 , 21 , 22 , 23 ]. Nanoparticles in general, and dendrimers in particular, that encapsulate or conjugate biologically active molecules or drugs can be considered best-in-class when used clinically.…”

The Influence of School Factors on Students’ Mathematics Achievements in Trends in International Mathematics and Science Study (TIMSS) in Abu Dhabi Emirate Schools

“…According to Incikabi et al [59], the principal's experience plays a vital role in determining and influencing teachers' professional development. That reflects in teachers helping their students achieve better performance in their education [60].…”