First‐in‐human implantation of a fully bioabsorbable drug‐eluting stent: The BVS poly‐<scp>L</scp>‐lactic acid everolimus‐eluting coronary stent

Ormiston, John A.; Webster, Mark; Armstrong, Guy

doi:10.1002/ccd.20895

Cited by 118 publications

(59 citation statements)

References 4 publications

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“…2 Currently, the everolimus-eluting BVS stent (Abbott Vascular, Santa Clara, USA), a coronary polymer stent based on PLLA, is being investigated in the ABSORB clinical trial. 19 Recent data on the in vivo performance of this stent, which has a strut thickness of 150 lm at a nominal diameter of 3.0 mm, is very promising and demonstrates an acute recoil comparable to a metallic stent. 25 A larger number of groups have already demonstrated the high potential of their technology in the experimental stage.…”

Section: Introductionmentioning

confidence: 94%

A Biodegradable Slotted Tube Stent Based on Poly(l-lactide) and Poly(4-hydroxybutyrate) for Rapid Balloon-Expansion

et al. 2007

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Abstract-Safe vascular stent application requires rapid expansion of the stent to minimize the risk of procedural ischemia. While high expansion speeds can be achieved with metallic stents, they are not necessarily feasible with biodegradable polymeric stents due to the viscoelastic material behavior. This study reports on a novel biodegradable polymer blend material based on poly(L-lactide) (PLLA) and poly(4-hydroxybutyrate) (P4HB), and describes the mechanical properties and in vitro degradation behavior of a balloon-expandable slotted tube stent concept. The stent prototypes with nominal dimensions of 6.0 · 25 mm were manufactured by laser machining of solution cast PLLA/ P4HB tubes (I.D. = 2.8 mm, d = 300 lm). The stents were expanded within 1 min by balloon inflation to 8 bar, after 5 min preconditioning in 37°C water. Recoil and collapse pressure were 4.2% and 1.1 bar, respectively. During in vitro degradation collapse pressure initially increased to a maximum at 4 w and then decreased thereafter. After 48 w, molecular weight was decreased by 82%. In summary, the PLLA/P4HB slotted tube stents allowed for rapid balloonexpansion and exhibited adequate mechanical scaffolding properties suitable for a broad range of vascular and nonvascular applications.

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Section: Introductionmentioning

confidence: 94%

A Biodegradable Slotted Tube Stent Based on Poly(l-lactide) and Poly(4-hydroxybutyrate) for Rapid Balloon-Expansion

et al. 2007

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“…Bioresorbable scaffolds (BRS), developed to theoretically overcome most of such limitations, are the so-called 4th revolution in interventional cardiology and have the potential to significantly improve coronary artery disease treatment (6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Magmaris: a new generation metallic sirolimus-eluting fully bioresorbable scaffold: present status and future perspectives

Rapetto¹,

Leoncini²

2017

J. Thorac. Dis.

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Drug-eluting stents (DES) have reached a high safety and efficacy profile, becoming the best option for percutaneous coronary interventions (PCI) based revascularization. However, despite their optimal performance, a few concerns remain regarding their use, mainly due to permanent caging of the vessels and its consequences, first of all late stent thrombosis (ST). Bioresorbable scaffolds (BRS) aim to overcome these issues. The results achieved in randomized controlled trials (RCT) by the first generation of poly-L-lactic acid (PLLA) based scaffolds were promising at 1 year, but the first long term reports (albeit flawed by nonoptimal implantation technique) have been disappointing, showing, for instance, an increased risk of ST and target vessel myocardial infarction (TV-MI). In such a scenario the advent of a newer generation magnesium (Mg) based BRS is welcome, mainly because of its innovative mechanical and chemical features coupled with well proven biocompatibility. Despite being in its infancy, this technology seems to promise a great potential.In our article, we review the Magmaris (Biotronik AG, Bülach, Switzerland) Mg BRS development from animal models to human use, underscore its best qualities and weaknesses, and provide hints of its possible future perspectives.

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“…In the ABSORB I Trial, 12 months after implantation restenosis rates were slightly higher in case of BVS (22.9 %) compared to BMS stents (19.3 %). The mean percent acute recoil was also higher for BVS stent (6.85 ± 6.96 % vs. 4.27 ± 7.08 %) [7][8][9][10]. On the basis of these results it was concluded that BVS stents were characterized by weaker scaffolding properties than the Xience V metallic implants.…”

Section: Introductionmentioning

confidence: 99%

Mechanical, rheological, fatigue, and degradation behavior of PLLA, PGLA and PDGLA as materials for vascular implants

et al. 2012

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The biggest challenge in the treatment of arterial stenosis remains the issue of optimization of stent design. Despite continuous improvement in surgical techniques and use of intensive pharmacotherapy, the results of stent coronary interventions may be unsatisfactory, and long-term interaction of a metal implant with a blood vessel results in complications such as recurrent stenosis and thrombosis. Therefore, it is necessary to search for new materials and stent designs to obtain a stent capable of restoring flow in the vessel and disappearing after fulfilling its function. Such stent must also be compatible with the vessel wall to enable regeneration of new structure of endothelium and deeper artery layers damaged during implantation. Consequently, there is ongoing search for functional solutions with minimum effects of long-term implant-tissue interaction. In light of the above, the team investigated the possibility of using biodegradable polymers already mentioned in the literature as a construction material for vascular stent. The study used three polyhydroxyacids based on lactic acid and glycolic acid: poly(l-lactide), poly(lactideco-glycolide) and poly(d,l-lactide-co-glycolide). The research focused on assessing changes in mechanical, thermomechanical, rheological, and fatigue properties during the process of hydrolytic degradation. The analysis also covered the rate of release of degradation products. The results of the conducted tests indicate the possibility of developing a vascular stent with biodegradable polymers.

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First‐in‐human implantation of a fully bioabsorbable drug‐eluting stent: The BVS poly‐L‐lactic acid everolimus‐eluting coronary stent

Cited by 118 publications

References 4 publications

A Biodegradable Slotted Tube Stent Based on Poly(l-lactide) and Poly(4-hydroxybutyrate) for Rapid Balloon-Expansion

A Biodegradable Slotted Tube Stent Based on Poly(l-lactide) and Poly(4-hydroxybutyrate) for Rapid Balloon-Expansion

Magmaris: a new generation metallic sirolimus-eluting fully bioresorbable scaffold: present status and future perspectives

Mechanical, rheological, fatigue, and degradation behavior of PLLA, PGLA and PDGLA as materials for vascular implants

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