First Isolation of a Oseltamivir-Resistant Influenza A (H1N1) Strain in Argentina

Cané, Alejandro; Casanueva, Enrique; Iolster, Tomás; Sticco, Nicolás; Richards, Lucía; Sosa, Patricia; Pontoriero, Andrea; Avaro, Martín; Zcech, Andrea; Carabajal, Eliana; Campos, Ana Maria de; Baumeister, Elsa; Diez, María Avila; Rojas, María; Rivarola, Manuel Rocca

doi:10.1097/inf.0b013e3181cd7244

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…The use of antibiotic and/or neuraminidase inhibitors in the treatment of patients with influenza was reported in three studies 2,71,72 . Oseltamivir resistance of influenza A (H1N1) 2009 virus was reported in two studies in Argentina 85,86 …”

Section: Resultsmentioning

confidence: 99%

“…2,71,72 Oseltamivir resistance of influenza A (H1N1) 2009 virus was reported in two studies in Argentina. 85,86 Influenza-like illnesses also resulted in absenteeism and workdays lost, being the total number of work days lost (in unvaccinated population) of 17, 1 102, 45 and 150 days 45 in the three analyzed studies, respectively. Hospitalization due to influenza or ILI led to several direct (e.g., hospitalization, diagnosis, and treatment) and indirect costs (domestic help, transportation, loss of productivity due to absenteeism).…”

Section: Use Of Resourcesmentioning

confidence: 99%

See 1 more Smart Citation

Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis

Savy

Ciapponi

Bardach

et al. 2012

Influenza Resp Viruses

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Please cite this paper as: Savy et al. (2012) Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12036. Objective Influenza causes severe morbidity and mortality. This systematic review aimed to assess the incidence, etiology, and resource usage for influenza in Latin America and the Caribbean. Design Meta‐analytic systematic review. Arcsine transformations and DerSimonian Laird random effects model were used for meta‐analyses. Setting A literature search from 1980 to 2008 in MEDLINE, Cochrane Library, EMBASE, LILACS, Ministries of Health, PAHO, proceedings, reference lists, and consulting experts. Sample We identified 1092 references, of which 31 were finally included, in addition to influenza surveillance reports. We also used information from the 10 reports from the collaborative group for epidemiological surveillance of influenza and other respiratory virus (GROG), and information retrieved from the WHO global flu database FLUNET. Main outcome measures Incidence, percentage of influenza specimens out of the total received by influenza centers and resource‐use outcomes. Results A total of 483 130 specimens of patients with influenza were analyzed. Meta‐analysis showed an annual rate of 36 080 (95%CI 28 550 43 610) influenza‐like illness per 100 000 persons‐years. The percentage of influenza out of total specimens received by influenza centers ranged between 4.66% and 15.42%, with type A the most prevalent, and A subtype H3 predominating. The mean length of stay at hospital due to influenza ranged between 5.8 12.9 days, total workdays lost due to influenza‐like illnesses were 17 150 days, and the mean direct cost of hospitalization was US$575 per laboratory‐confirmed influenza case. Conclusions Our data show that seasonal influenza imposes a high morbidity and economic burden to the region. However, the vaccine‐uptake rate has been low in this region. Population‐based cohort studies are required to improve the knowledge about incidence and resource utilization, which would inform healthcare authorities for decision making.

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Section: Resultsmentioning

confidence: 99%

Section: Use Of Resourcesmentioning

confidence: 99%

Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis

Savy

Ciapponi

Bardach

et al. 2012

Influenza Resp Viruses

View full text Add to dashboard Cite

show abstract

“…There is no information that any of these isolates were obtained from persons who were treated or were in close contact with another individual who was treated with antiviral drugs. Therefore, oseltamivir resistance is unlikely to be related to antiviral medication of patients, as in other countries, where there are few instances of resistant viruses being isolated from persons who have been treated or have been in close contact with another individual who was treated with oseltamivir (25,26).…”

Section: Discussionmentioning

confidence: 99%

Virological surveillance and antiviral resistance of human influenza virus in Argentina, 2005-2008

Pontoriero¹,

Baumeister²,

Campos³

et al. 2011

Rev Panam Salud Publica

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This study describes a high incidence of amantadine-resistant influenza A(H3N2) viruses since 2006 and an unprecedented increase in oseltamivir resistance detected only in influenza A(H1N1) viruses isolated in 2008. Influenza A and B viruses were more sensitive to oseltamivir than to zanamivir, and influenza A viruses were more sensitive to both neuraminidase inhibitors than the influenza B viruses. The national data generated and analyzed in this study may help increase knowledge about influenza antiviral drug resistance, which is a problem of global concern.

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Commentary: A Historical Review of Centers for Disease Control and Prevention Antiviral Treatment and Postexposure Chemoprophylaxis Guidance for Human Infections With Novel Influenza A Viruses Associated With Severe Human Disease

Havers

Campbell

Uyeki

et al. 2017

The Journal of Infectious Diseases

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Human infections with novel influenza A viruses are of global public health concern, and antiviral medications have a potentially important role in treatment and prevention of human illness. Initial guidance was developed by the U.S. Centers for Disease Control and Prevention after the emergence of human infections with avian influenza A(H5N1) and has evolved over time, with identification of influenza A(H7N9) virus infections in humans, as well as detection of avian influenza viruses in birds in the United States. This commentary describes the historical context and current guidance for the use of influenza antiviral medications for treatment and post-exposure chemoprophylaxis of human infections with novel influenza A viruses associated with severe human illness, or with the potential to cause severe human disease, and provides the scientific rationale behind current recommendations.

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First Isolation of a Oseltamivir-Resistant Influenza A (H1N1) Strain in Argentina

Cited by 5 publications

References 2 publications

Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis

Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis

Virological surveillance and antiviral resistance of human influenza virus in Argentina, 2005-2008

Commentary: A Historical Review of Centers for Disease Control and Prevention Antiviral Treatment and Postexposure Chemoprophylaxis Guidance for Human Infections With Novel Influenza A Viruses Associated With Severe Human Disease

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