First isolation of ciprofloxacin-resistant Salmonella enterica serovar Typhi in Taiwan

Abstract

The first ciprofloxacin-resistant S. Typhi infection in Taiwan is reported. The emergence and spread of antimicrobial-resistant S. Typhi infection as a result of international travel may become a threat to public health in Taiwan. Clinicians should be well alert when treating patients who may have acquired resistant infections associated with international travel among endemic regions.

Molecular characterization of antimicrobial susceptibility of Salmonella isolates: First identification of a plasmid carrying qnrD or oqxAB in Taiwan

“…6,7 Quinolone resistance in Enterobacteriaceae is mainly due to point mutations in the quinolone resistancedetermining regions (QRDRs) of the target genes that encode topoisomerases, namely DNA gyrase (gyrA and gyrB) and DNA topoisomerase IV (parC and parE ). 8,9 Downexpression of porins or over-production of efflux pumps also contribute to quinolone resistance by leading to decreased membrane permeability, thus causing a reduction in the concentration of antimicrobial agents in the cytoplasm. 8,10 The major efflux pump systems identified in Salmonella are resistanceenodulationedivision (RND) efflux transporters (AcrAB-TolC and AcrEF) and EmrAB (belongs to the major facilitator superfamily, MFS).…”

Lack of efflux mediated quinolone resistance in Salmonella enterica serovars Typhi and Paratyphi A

“…Typhi and S . Paratyphi A human isolates from India or from Taiwan (Gaind et al, 2006; Lee et al, 2013). …”

Food Safety and Antimicrobial Resistance an Approach to the Genus <i>Salmonella</i> spp.

“…While some serotypes such as Salmonella typhi, causative agent of typhoid fever, are known to present multi-drug resistance, ciprofloxacin being the only effective antibiotic against it [18]. However in 2015, Lee et al [40] isolated first of ciprofloxacin-resistant Salmonella enterica serovar typhi in Taiwan. The emergence and spread of antimicrobial-resistant S. typhi infection as a result of international travel may become a threat to public health in Taiwan.…”