First Molecular Characterization of Poxviruses in Cattle, Sheep, and Goats in Botswana

Modise, Boitumelo Magret; Settypalli, Tirumala Bharani Kumar; Kgotlele, Tebogo; Xue, Dingrong; Ntesang, K.; Kumile, Kago; Naletoski, Ivancho; Nyange, J.; Thanda, Carter; Macheng, Kenny Nametso; Marobela-Raborokgwe, Chandapiwa; Viljoen, G. J.; Cattoli, Giovanni; Lamien, Charles Euloge

doi:10.21203/rs.3.rs-419694/v1

Cited by 2 publications

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References 17 publications

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“…Poxviruses are complex, linear, enveloped, double-stranded DNA viruses with large genomes [ 48 ], which are responsible for several economically significant zoonotic diseases affecting humans, wildlife, farm animals, and domestic animals [ 23 ]. They belong to the Poxviridae family, which is divided into two subfamilies: Entomopoxvirinae, which infect invertebrates, and Chordopoxvirinae, which infect vertebrates [ 30 , 42 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

“…They belong to the Poxviridae family, which is divided into two subfamilies: Entomopoxvirinae, which infect invertebrates, and Chordopoxvirinae, which infect vertebrates [ 30 , 42 , 45 ]. Among the Chord poxvirus subfamily, Capripoxvirus is capable of infecting the cattle, sheep, and goats, which is comprised of goat pox virus (GTPV), sheep pox virus (SPPV), and LSDV and Parapoxvirus [ 5 , 16 , 21 , 48 , 72 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and molecular studies on cattle naturally infected with lumpy skin diseases in selected districts of Wolaita Zone, Southern Ethiopia

et al. 2022

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Background Lumpy skin disease is a contagious viral disease of cattle caused by LSDV that results in huge economic losses in the cattle industry. This study characterizes LSDV in cattle through clinicopathological and molecular techniques in selected districts of Wolaita Zone, Southern Ethiopia. Methods A crossectional study was conducted from November 2020 to June 2021 using Real-time polymerase chain reaction and Histopathological techniques to confirm LSDV. Result This study revealed that the percentage of positivity of cattle for LSDV was 36.2%. Clinically, cattle infected with LSDV revealed fever (39–41 °C), nodular lesions on the skin and mucous membranes, and lymphadenopathy. Histopathologically, affected tissue revealed ballooning degenerations of the epidermis, infiltration of mononuclear inflammatory cells, vasculitis, and intracytoplasmic eosinophilic inclusion bodies. RT-PCR confirmed that DNA extracts from skin biopsies of virus isolates were positive for LSDV. Conclusion The present study confirms that LSDV is widely circulating in cattle of selected districts of the Wolaita zone. Thus, effective control measures through regular vaccination and further confirmation of circulating strains of LSDV through detailed molecular analysis should be recommended.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinicopathological and molecular studies on cattle naturally infected with lumpy skin diseases in selected districts of Wolaita Zone, Southern Ethiopia

et al. 2022

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Lumpy Skin Disease: A review of epidemiological study and preventive measures

Ahmed

2024

BJVM

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Background: Lumpy skin disease (LSD) is a highly infectious and economically important transboundary disease that is rapidly spreading to the globe. The disease causes high morbidity and a low mortality rate of infection. The animals show acute or chronic illnesses depending on the immune responses of the hosts. The economic burden of LSD manifested the poor-quality hides, a drop in milk and meat production, abortion, and death. Methods: This systematic literature review was accomplished according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The literature on lumpy skin disease has been explored over the last two decades and searched keywords on online databases such as Google Scholar, PubMed, and Scopus. Both automated and manual searching tools were used to screen the articles. The literature published other than English was rejected during the screening process. Conference papers were excluded during the screening. Results: LSD is transmitted by blood-sucking arthropods and is most prevalent in summer and rainy seasons. Exotic-bred cattle and calves are highly susceptible. Although the disease has low mortality, the high mortality of the disease prevails in endemic regions in complicated cases. Calves from unvaccinated cows should be vaccinated at any age, on the other hand, the calves from vaccinated cows should be immunized at 3 months of age. Animals should be vaccinated before the risk period. Strict biosecurity, quarantine, and immunoprophylaxis can reduce the prevalence of the disease. Conclusions: Lumpy skin disease (LSD) is an acute infectious and contagious disease affecting cattle and water buffaloes. The disease causes serious economic loss due to decreased production, skin problems, and mortality in complicated cases. Further details on genetic characterization, transmission dynamics, and host-pathogen interaction should be performed to prevent the prevalence of the disease in emerging or re-emerging countries.

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First Molecular Characterization of Poxviruses in Cattle, Sheep, and Goats in Botswana

Cited by 2 publications

References 17 publications

Clinicopathological and molecular studies on cattle naturally infected with lumpy skin diseases in selected districts of Wolaita Zone, Southern Ethiopia

Clinicopathological and molecular studies on cattle naturally infected with lumpy skin diseases in selected districts of Wolaita Zone, Southern Ethiopia

Lumpy Skin Disease: A review of epidemiological study and preventive measures

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