A second United States death from severe outcomes in the face of monkeypox infection has, along with the first and others in Spain, Brazil, India, Ecuador, Peru, Mexico and Cuba confirmed one of the monkeypox predictions of the theory of “The origin of the mysterious multi-country monkeypox outbreak in non-endemic countries” of June 2, 2022 which was obtained with the superior Einsteinian method that illustrates the reality in which phenomena occur and deduces only the consequences of the results obtained to ascertain their perfect correspondence with the data of experience and their mutual relations. The current theory is unable to explain how severe outcomes which it logically deduced to be direct consequences of the transmission of a virus that causes a single respiratory and skin disease should, in some of the infected, include conditions such as encephalitis. And just as no hypothesis was able to modify Sir Isaac Newton’s theory of gravitation in a manner that could give it the capacity to account for the behavior of the orbit of Mercury, the “immunodeficiency” hypothesis is unable to give the current theory the capacity to account for the occurrence of such severe outcomes which occur even in healthy individuals such as the two who were killed by them in Spain. And just as the exact behavior of the orbits of all planets, which was not anticipated or explained by the Newtonian theory of gravitation, is a consequence of the results of the illustration of physical reality which enabled Albert Einstein to predict and explain it, the spectrum of clinical outcomes that appear in the infected is neither expected nor explained by the current theory because such outcomes are all consequences of the illustration of biological reality which permitted the predictions of June 2, 2022. The results of this illustration revealed that the severe outcomes that cause deaths in the infected do not occur because of mere transmission of the pathogen but rather because of the disappearance of the immunological conditions that prevent pathological mechanisms from responding to the influences of the pathogen and the causes of diseases in the same immunological spectrum as the disease it causes (the infectious disease). And the consequence of the disappearance of such conditions that protect us from all the diseases in the immunological spectrum of the disease that the monkeypox virus causes is the co-manifestation of such diseases which, depending on which among their causes are present alongside the virus, may result in encephalitis or other conditions which would appear to be unrelated to this infectious disease (monkeypox) for as long as we see it as a single respiratory and skin disease that is being transmitted by the monkepox virus through the lens of the current theory of infectious disease pathogenesis. If the disappearance of such immunological conditions should become sufficiently widespread before we understand them enough to restore them wherever they have disappeared, our populations will be decimated by such severe outcomes irrespective of how little we have deduced the virulence of the pathogen to be from case fatality ratios. The abandonment of the current theory of infectious disease pathogenesis which is clearly fatal to medical progress in favor of the spectral theory will demonstrate our readiness for the illustration of biological reality that leads to such understanding and our willingness to do all we must for the completion of this most important illustration in the shortest possible time.