Monitoring, measuring and controlling electronic systems in space exploration, automotive industries, downhole oil and gas industries, oceanic environment, geothermal power plants, etc. require materials and processes that can withstand harsh environments. Such harshness can come from the surrounding temperature, varying pressure, intense radiation, reactive chemicals, humidity, salinity, or a combination of any of these conditions. Here, we review recent progress in the development of flexible and stretchable electronic devices for harsh environment applications. We consider studies on how the selection of a specific material is important for a specific application and how the selection of the material plays critical role in sustained performance. We present specific examples for selected applications. We also look at works on methods and designs for achieving flexibility and stretchability in devices designed for harsh environments. Finally, we look at studies on Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation packaging techniques that enable deployment of conventional electronic devices in harsh environment applications and offer a few examples.