First Report of Fusarium Rot of Phalsa (<i>Grewia asiatica</i>) Caused by <i>Fusarium solani</i> in Pakistan

Moosa, Anam; Farzand, Ayaz; Ahmad, Tanvir; Khan, Sajid Aleem; Abbas, Huma; Khan, Waqas; Jabbar, Abdul; Mohsan, Muhammad

doi:10.1094/pdis-04-19-0688-pdn

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…For example, lycopene improved oxidative stress and endoplasmic reticulum stress-induced damage on neuroblastoma cells by reducing expression levels of 8-hydroxydeoxyguanosine, malondialdehyde (MDA), and protein carbonyls and inhibiting the protein kinase-like endoplasmic reticulum kinase (PERK) signaling pathway [ 48 ]. Grewia asiatica berry is a popular berry in Pakistan that is mainly consumed in the form of carbonated drinks and fresh juices and is rich in phenols, anthocyanins, vitamin C, and flavonoids [ 49 ]. Grewia asiatica berry juice could improve depressive symptoms by decreasing oxidative damage in the brain through increasing superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels [ 50 ].…”

Section: Depressionmentioning

confidence: 99%

Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

Zhou

et al. 2022

Antioxidants

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Depression and anxiety are severe public health problems and have attracted more and more attention from researchers of food science and nutrition. Dietary natural products and nutrients, such as fish, coffee, tea, n-3 PUFA, lycopene, and dietary fiber, could play a vital role in the prevention and management of these diseases. The potential mechanisms of action mainly include inhibiting inflammation, ameliorating oxidative stress, modulating the microbiota–gut–brain axis, suppressing hypothalamic–pituitary–adrenal axis hyperactivity, and regulating the levels of monoamine neurotransmitters. In this narrative review, we summarize the most recent advancements regarding the effects of dietary natural products and nutrients on depression and anxiety, and their underlying mechanisms are discussed. We hope that this paper can provide a better understanding of the anti-depressive and anxiolytic action of dietary natural products, and that it is also helpful for developing dietary natural products for functional food, dietary supplements, or auxiliary agents for the prevention and management of these diseases.

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Section: Depressionmentioning

confidence: 99%

Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

Zhou

et al. 2022

Antioxidants

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“…Grewia asiatica L. is a unique plant which grows wild as well as cultivated domestically. It produces an acidic, sour fruit used in South East Asia and its adjacent regions (Moosa et al, 2019). Plant fruit is edible, delicious, and known, locally, as phalsa.…”

Section: Grewia Asiatica Lmentioning

confidence: 99%

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2022

Pak. J. Pharm. Sci.,

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Grewia asiatica L. is a potential medicinal plant used for various diseases in traditional medicine. Current study was aimed to evaluate the cardio protective, anti-inflammatory, analgesic and CNS depressant activities of Grewia asiatica L. fruit extract. In cardio protective activity myocardial injury was produced by injection of Isoproterenol (200 mg/kg, s.c), G. asiatica 250 and 500mg/kg treated groups significantly (p<0.05) decreased the level of serum AST, ALT, LDH and CKMB, hence produced cardio protective effect. In analgesic activities G. asiatica produced significant (p<0.05) analgesic effects in acetic acid induced writhing, formalin, paw pressure and tail immersion test. G. asiatica at 250 and 500mg/kg oral dose, significantly (p<0.05) reduced the rat paw edema in carrageen an induced rat paw edema test. G. asiatica extract also produced significant CNS depressant effects in open field, hole board and thiopental sodium induced sleeping time. Findings of the current study suggest that G. asiatica fruit extract showed potential pharmacological effects and can be utilized in alternative medicine.

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“…Out of these, about 10 species are found in Pakistan ( 6 ). Grewia asiatica L. is one variety that grows wild and is cultivated as well, providing a sour, acidic fruit used in South Asian countries ( 7 ). The fruit of this plant is locally known as phalsa.…”

Section: Introductionmentioning

confidence: 99%

Grewia asiatica Berry Juice Diminishes Anxiety, Depression, and Scopolamine-Induced Learning and Memory Impairment in Behavioral Experimental Animal Models

et al. 2021

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Grewia asiatica L. fruit natively called phalsa is a popular berry of Pakistan and widely consumed in the form of fresh juices and carbonated drinks in the summer season. The berry is enriched with antioxidants such as phenols, flavonoids, anthocyanins, and vitamin C. Scientifically, it is the least explored berry in terms of neuromodulatory activities, and therefore, in the designed study, chronically fed rats with the different dilutions (5%−30%) of fruit juice were subjected to behavioral assessment for anxiety, depression, and cognition (spatial memory) followed by biochemical analysis of isolated brains. Results revealed a prominent impact of 20 and 30% dilutions of fruit exudate as treated animals showed anxiolytic behavior to central zone (P < 0.05) of open field test (OFT) and open arms of elevated plus maze (EPM) (P < 0.05) in anxiety models. Overall, immobility of rats treated with a higher concentration of exudate in forced swim test (FST) was reduced (P < 0.05) presenting antidepressant-like activity. Moreover, in learning and memory experimental models, the treated animals reversed scopolamine-induced amnesic effects as evident from improved step-through latencies (P < 0.05 vs. scopolamine; passive avoidance test), spontaneous alternation behavior (P < 0.05 vs. scopolamine; Y-maze test), discrimination index (P < 0.05 vs. scopolamine; novel object recognition test), and escape latencies (P < 0.05 vs. scopolamine; Morris water maze). Biochemical studies of isolated brains from treated rats demonstrated significantly elevated levels of superoxide dismutase and glutathione peroxidase (P < 0.05), whereas levels of acetylcholinesterase and malondialdehyde level (P < 0.05) were reduced, indicating its potential to reduce oxidative damage in the brain and modulation with the cholinergic system. The outcomes of studies support the benefits of phytoconstituents possessed by G. asiatica fruit in the amelioration of neurological disorders that could be due to their antioxidative capacity or due to interaction with GABAergic, serotonergic, and cholinergic systems in the brain.

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First Report of Fusarium Rot of Phalsa (Grewia asiatica) Caused by Fusarium solani in Pakistan

Cited by 4 publications

References 5 publications

Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

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Grewia asiatica Berry Juice Diminishes Anxiety, Depression, and Scopolamine-Induced Learning and Memory Impairment in Behavioral Experimental Animal Models

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