First report of high levels of clindamycin‐resistant Propionibacterium acnes carrying erm(X) in Japanese patients with acne vulgaris

Nakase, Keisuke; Nakaminami, Hidemasa; Noguchi, Norihisa; Nishijima, Satoshi; Sasatsu, Masanori

doi:10.1111/j.1346-8138.2011.01423.x

Cited by 41 publications

(44 citation statements)

References 8 publications

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“…In spite of the high frequency of antibiotic use, however, a low rate of antibiotic-resistant strains (4-20.9%) has been reported in some Japanese studies [20,21,22]. The reason for this has not been well investigated.…”

Section: Discussionmentioning

confidence: 90%

Analysis of Facial Skin-Resident Microbiota in Japanese Acne Patients

et al. 2013

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Objectives: We investigated the facial skin microbiota of Japanese acne patients. Methods: Skin swab samples were obtained from 100 acne patients and 28 healthy controls to evaluate Propionibacterium and Staphylococcus spp. using a culture method. Malassezia spp. were evaluated using a nonculture method. Antibiotic resistance of Propionibacterium spp. was also examined. Results: Acne patients and controls did not show significant differences in Propionibacterium and Staphylococcus spp. populations. However, the number of Malassezia globosa from patients was greater than that from controls. Moreover, the number of Propionibacterium spp. from patients carrying antibiotic-resistant strains was significantly greater than that from patients not carrying them. Conclusions: The present study characterized the facial skin microbiota of Japanese acne patients, suggesting a correlation between acne and quantitative differences in Malassezia microbiota. It was also found that the antibiotic resistance of Propionibacterium spp. may affect its abundance in the skin.

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Section: Discussionmentioning

confidence: 90%

Analysis of Facial Skin-Resident Microbiota in Japanese Acne Patients

et al. 2013

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“…There is widespread resistance in P. acnes due to overuse of topical and systemic antibiotics for treatment of acne vulgaris [3,[8][9][10][11][12][13][14][15][16], as shown in Table 4. Various studies have used different interpretative criteria to estimate the resistance among P. acne strains to different anti-acne drugs.…”

Section: Discussionmentioning

confidence: 99%

In vitro antimicrobial susceptibility patterns of Propionibacterium acnes isolated from patients with acne vulgaris

Biswal

Gaind

Kumar

et al. 2016

J Infect Dev Ctries

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Introduction: Propionibacterium acnes has been implicated in the development of acne vulgaris. Rampant use of topical and systemic antibiotics for acne vulgaris has led to resistance due to selective pressure. This study aimed to determine antibiotic resistance of P. acnes. Methodology: A total of 102 samples were collected from acne lesions and cultured onto sheep's blood agar and brain-heart infusion agar supplemented with 5 g/L glucose and 2 mg/L furazolidone) (BHIg) under aerobic and anaerobic conditions. Species identification was done by conventional methods and the VITEK2 Compact system. The isolates were tested for penicillin, erythromycin, clindamycin, ciprofloxacin, nadifloxacin, and tetracycline by E-test, and minimum inhibitory concentration (MIC) of minocycline was determined by agar dilution on BHIg. MIC results were interpreted as per EUCAST (European Committee on Antimicrobial Susceptibility Testing) and CLSI (Clinical Laboratory Standards Institute) guidelines. Results: P. acnes was the most common anaerobe (66%) isolated. Resistance rates using EUCAST and CLSI breakpoints were 10.6% and 6.1%, 7.6% and 0%, 7.8% and 0% for erythromycin, clindamycin, and minocycline, respectively. Tetracycline resistance was observed in 9.2% isolates irrespective of the interpretative criteria used. MIC50 and MIC90 values for nadifloxacin (0.25 and 1 µg/mL) were found to be twofold lower than those for ciprofloxacin (0.5 and 1 µg/mL). Similarly, MIC50 and MIC90 values for minocycline (0.125 and 0.5 µg/mL) were also two-to threefold lower than those for tetracycline (0.38 and 1 µg/mL). Conclusions: To the best of our knowledge, this is the first study focusing on P. acnes resistance from India.

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“…Topical nadifloxacin and clindamycin are frequently used for the treatment of acne vulgaris and impetigo in Japan [3,4], while topical gentamicin and fusidic acid are used for the treatment of a wide range of skin infections [5]. Recently, clindamycin-resistant P. acnes, which contribute to refractory skin infections, have been frequently isolated in the USA, Europe, and Japan [2,6]. Methicillin-resistant S. aureus (MRSA) is a well-known major pathogen in healthcare-associated infections.…”

Section: Introductionmentioning

confidence: 99%

“…Propionibacterium acnes and Staphylococcus aureus are pathogens of skin infections, such as acne vulgaris and impetigo, respectively [1,2]. Topical nadifloxacin and clindamycin are frequently used for the treatment of acne vulgaris and impetigo in Japan [3,4], while topical gentamicin and fusidic acid are used for the treatment of a wide range of skin infections [5].…”

Section: Introductionmentioning

confidence: 99%

Determination of the Mutant Prevention Concentration and the Mutant Selection Window of Topical Antimicrobial Agents against Propionibacterium acnes

et al. 2016

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Determination of the mutant prevention concentration (MPC) and the mutant selection window (MSW) of antimicrobial agents used to treat pathogenic bacteria is important in order to apply effective antimicrobial therapies. Here, we determined the MPCs of the major topical antimicrobial agents against Propionibacterium acnes and Staphylococcus aureus which cause skin infections and compared their MSWs. Among the MPCs of nadifloxacin and clindamycin, the clindamycin MPC was determined to be the lowest against P. acnes. In contrast, the nadifloxacin MPC was the lowest against S. aureus. Calculations based on the minimum inhibitory concentrations and MPCs showed that clindamycin has the lowest MSW against both P. acnes and S. aureus. Nadifloxacin MSWs were 4-fold higher against P. acnes than against S. aureus. It is more likely for P. acnes to acquire resistance to fluoroquinolones than S. aureus. Therefore, topical application of clindamycin contributes very little to the emergence of resistant P. acnes and S. aureus strains.

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First report of high levels of clindamycin‐resistant Propionibacterium acnes carrying erm(X) in Japanese patients with acne vulgaris

Cited by 41 publications

References 8 publications

Analysis of Facial Skin-Resident Microbiota in Japanese Acne Patients

Analysis of Facial Skin-Resident Microbiota in Japanese Acne Patients

In vitro antimicrobial susceptibility patterns of Propionibacterium acnes isolated from patients with acne vulgaris

Determination of the Mutant Prevention Concentration and the Mutant Selection Window of Topical Antimicrobial Agents against <b><i>Propionibacterium acnes</i></b>

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