First report of infection of Lutzomyia longipalpis by Leishmania (Leishmania) infantum from a naturally infected cat of Brazil

Silva, Sydnei Magno da; Rabelo, Priscila Fonte Boa; Gontijo, Nelder F.; Ribeiro, Raul Rio; Melo, Maria Norma; Ribeiro, Vítor Márcio; Michalick, Marilene Suzan Marques

doi:10.1016/j.vetpar.2010.08.005

Cited by 79 publications

(90 citation statements)

References 27 publications

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“…In Brazil, the presence of L. infantum promastigotes in the midgut of Lutzomyia longipalpis, as demonstrated by xenodiagnosis, recently confirmed the presence of parasites in the skin of a cat, suggesting the ability of this animal to act as a source of infection 5 .…”

Section: Visceral Leishmaniasis (Vl) Is a Protozoan Disease Caused Bymentioning

confidence: 80%

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Detection of antibodies against Leishmania infantum in cats (Felis catus) from the State of Pernambuco, Brazil

Silva

Ramos

Pimentel

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de MedicinaABSTRACT Introduction: Little information is available concerning infection by Leishmania infantum in cats. Therefore, the aim of this study was to perform a serological study in domestic cats. Methods: Serum samples (n=153) obtained from animals living in the Cities of Recife and Petrolina, State of Pernambuco, Brazil, were tested by ELISA/S7 ® (Biogene). Results: Anti-L. infantum antibodies were detected in 3.9% (6/153) of the cats. All seroreagent animals were from Petrolina. Conclusions: These results serve as an important alert, and future studies are needed to better understand the possible role of cats in the epidemiology of visceral leishmaniasis (VL) in this area.

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Section: Visceral Leishmaniasis (Vl) Is a Protozoan Disease Caused Bymentioning

confidence: 80%

“…Moreover, it is important to assess infection by vectors that feed on L. infantumpositive cats 4,5 . The present study was the first serological study performed on cats from Pernambuco.…”

Section: Conflict Of Interestmentioning

confidence: 99%

Detection of antibodies against Leishmania infantum in cats (Felis catus) from the State of Pernambuco, Brazil

Silva

Ramos

Pimentel

et al. 2014

Rev. Soc. Bras. Med. Trop.

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“…This finding contributed to the implementation of the largest epidemiological investigation ever carried out in cats in Brazil (ROSSI, 2007). In these studies, the sample prevalence obtained by RIFI and ELISA varied from 0.5% to 23%, respectively (SILVEIRA NETO et al, 2011;CARDIA et al, 2013), which demonstrates that the serological technique employed may influence the diagnosis. Moreover, a poor correlation of the Kappa coefficient was observed among the techniques of direct detection, such as cytology and immunohistochemistry, and indirect detection, such as RIFI and ELISA (VIDES et al, 2011;SOBRINHO et al, 2012).…”

Section: Diagnosismentioning

confidence: 93%

“…Cats infected by L. donovani and L. infantum may be urban reservoirs of visceral leishmaniasis, as they can transmit the protozoan to phlebotomine sandflies used in xenodiagnosis (SILVA et al, 2010;MAROLI et al, 2007), and present high parasitism in the skin as assessed by immunohistochemistry (VIDES et al, 2011). Interestingly, in 2004 an autochthonous case of feline visceral leishmaniasis was reported in Cotia -SP, where no cases of canine or human disease had been detected (SAVANI et al, 2004).…”

Section: Malnourishedmentioning

confidence: 99%

“…present exclusively skin changes. Moreover, studies used mainly cytology or antibody detection as diagnostic techniques, which were restricted to identify the parasite genus (SOUZA et al, 2005(SOUZA et al, , 2009FIGUEIREDO et al, 2009;SILVEIRA NETO et al, 2011). Currently, feline leishmaniasis is assessed by PCR followed by sequencing and genetic alignment, a diagnostic tool that facilitates the identification of the protozoan species.…”

Section: Clinical Signsmentioning

confidence: 99%

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Clinical and epidemiological aspects of feline leishmaniasis in Brazil

et al. 2015

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Tegumentary and visceral leishmaniasis are severe and unfortunately common parasitic diseases in Brazil. Among domestic animals, dogs are considered the main urban reservoir of the protozoan parasites, however, there is evidence that infected cats can also contribute towards the disease pool. The number of cats diagnosed with leishmaniasis has greatly increased in the last few years, highlighting the importance of thorough investigations on the role of the cat in the epidemiological cycle of the disease and in public health related issues. The main clinical manifestations of leishmaniasis suffered by cats, even when infected with Leishmania chagasi, a viscerotropic species, are skin abnormalities, which can be confounded with multiple other diseases. Indirect ELISA should be used as a screening test in epidemiological investigations for being a sensitive technique, followed by more specific laboratory tests. The standardization and validation of rapid, economical and reproducible diagnostic methods, to be employed in epidemiological surveillance, are still required. Key words: Leishmania spp., cat, epidemiology, diagnosis, zoonosis, prevalence ResumoLeishmaniose tegumentar e visceral são doenças parasitárias graves e, infelizmente, comuns no Brasil. Entre os animais domésticos, o cão é considerado o principal reservatório urbano do parasito protozoário; no entanto, há indícios de que gatos infectados também possam contribuir para essas doenças. O número de gatos com diagnóstico de leishmaniose aumentou muito nos últimos anos, destacando a importância de investigações aprofundadas sobre o papel desse hospedeiro no ciclo epidemiológico da doença e em Saúde Pública. As principais manifestações clínicas da leishmaniose felina são anormalidades na pele, o que pode ser confundida com várias outras doenças, mesmo em casos de infecção por Leishmania chagasi, uma espécie viscerotrópica. ELISA indireto poderia ser usado como teste de triagem em investigações epidemiológicas, por ser um método sensível, seguido de exames laboratoriais mais específicos. A padronização e validação de métodos de diagnóstico rápidos, econômicos e reprodutíveis a serem empregados na vigilância epidemiológica ainda são necessárias.

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Leishmaniosis

Pennisi¹

2020

Feline Dermatology

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Leishmania spp. affecting cats include L. infantum, L. mexicana, L. venezuelensis, L. amazonensis, and L. braziliensis. Leishmania infantum is the species most frequently reported in cats and causes feline leishmaniosis (FeL). Cats exposed to L. infantum are able to mount a cell-mediated immune response that does not parallel antibody production. Cats with L. infantum-associated clinical disease have positive blood PCR and low to very high antibody levels. About half of the clinical cases of FeL are diagnosed in cats with impaired immunocompetence. Skin or mucocutaneous lesions are the most common clinical findings; however, FeL is a systemic disease. Skin or mucocutaneous lesions and lymph node enlargement are seen in at least half of cases, ocular or oral lesions and some aspecific signs (weight loss, anorexia, lethargy) in about 20-30% of cases, and many other clinical signs (e.g., respiratory, gastrointestinal) are sporadically observed. Ulcerative and nodular lesions due to diffuse granulomatous dermatitis are the most frequent skin manifestations, mainly distributed on the head or symmetrically on the distal limbs. Diagnosis can be obtained by cytology and histology, and immunohistochemistry is useful to confirm the causative role of Leishmania infection in the dermopathological manifestations; however, other skin diseases may coexist with FeL. Polymerase chain reaction is used in case of suggestive lesions with lack of parasites and for Leishmania speciation. Comorbidities, coinfections, and chronic renal disease influence the prognosis and should be investigated. Treatment is currently based on the same drugs used for canine leishmaniosis, and generally clinical cure is obtained; however recurrence is possible.

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First report of infection of Lutzomyia longipalpis by Leishmania (Leishmania) infantum from a naturally infected cat of Brazil

Cited by 79 publications

References 27 publications

Detection of antibodies against Leishmania infantum in cats (Felis catus) from the State of Pernambuco, Brazil

Detection of antibodies against Leishmania infantum in cats (Felis catus) from the State of Pernambuco, Brazil

Clinical and epidemiological aspects of feline leishmaniasis in Brazil

Leishmaniosis

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