First report of New Delhi metallo-β-lactamase-6 (NDM-6) among  pneumoniae ST147 strains isolated from dialysis patients in Iran

Bahramian, Aghil; Shariati, Aref; Azimi, Taher; Sharahi, Javad Yasbolaghi; Bostanghadiri, Narjess; Gachkar, Latif; Ghalavand, Zohreh; Chirani, Alireza Salimi; Erfanimanesh, Soroor; Hashemi, Ali

doi:10.1016/j.meegid.2019.01.030

Cited by 35 publications

(26 citation statements)

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“…44 According to high antibiotic resistance among bacteria, in order to prevent undesirable effects of sepsis and septicemia, as well as in order to reduce the mortality rate due to these infections, precise detection and use of effective antibiotics for an efficient treatment are critical. 8,[45][46][47] Consequently, awareness of the antibiotic resistance patterns among common pathogens, holding workshops to correct prescription of empiric treatment, and changes in antimicrobial use are warranted and highly recommended. Finally, the results of DDM and MIC tests are of great importance, and individuals' free access to antibiotics should be prevented.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the antimicrobial resistance patterns among major bacterial pathogens isolated from clinical specimens taken from patients in Mofid Children’s Hospital, Tehran, Iran: 2013–2018

Azimi

Maham

Fallah

et al. 2019

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Background: This study evaluates the epidemiology and antimicrobial resistance profile of Gram-negative bacteria (GNB) and Gram-positive bacteria (GPB) isolated from clinical specimens in children admitted to Mofid Children's Hospital. Methods: This was a retrospective study of the patients' clinical specimens collected from January 2013 until the end of December 2018. All specimens were evaluated to determine the presence of infection-causing agents using a BACTEC 9120 blood culture. Isolation and identification of bacterial strains were performed using conventional biochemical tests. Antibiotic resistance was determined using Kirby-Bauer disk diffusion and broth microdilution methods. Results were interpreted according to CLSI and EUCAST. Results: A total of 1130 different pathogenic bacteria were detected from 14,690 different clinical specimens and the overall detection rate was 7.7% (1130/14,690). Among bacterial pathogen isolated from clinical specimens, 55% (n=622) were GNB and 45% (n=508) were GPB. The predominant GNB isolates were Pseudomonas aeruginosa, Klebsiella spp., Acinetobacter baumannii, Escherichia coli, Enterobacter spp., Citrobacter spp., respectively. Among GPB, CoNS was the most frequent and Enterococcus spp. was found to have low levels of resistance to linezolid. In GNB, most A. baumannii and P. aeruginosa were ceftriaxone resistant. P. aeruginosa was found to have low levels of resistance to levofloxacin and ciprofloxacin. Conclusions: Our findings revealed that the resistance rate among GNB and GPB associated with different infections in children is very high. These results suggest a constant screening and follow-up programs for the detection of antibiotic resistance, and it also suggests to develop antimicrobial stewardship programs in Tehran, Iran.

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Section: Discussionmentioning

confidence: 99%

Evaluating the antimicrobial resistance patterns among major bacterial pathogens isolated from clinical specimens taken from patients in Mofid Children’s Hospital, Tehran, Iran: 2013–2018

Azimi

Maham

Fallah

et al. 2019

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“…86,87 On the other hand, it should be noted that of extensively drug-resistant tuberculosis (XDR-TB), MDR Clostridium difficile and newly identified transmissible carbapenamase, New Delhi metallo-betalactamases (NDM) in Enterobacteriaceae are expanding all over the world, especially in developing countries, and may become a big problem in the coming years. 3,88,89 Intrinsic properties, such as external barriers, which prevent the entry of drugs into bacteria, natural mutations in antibiotic targets and acquired features, such as sequestration of the drug, efflux pumps and enzyme-dependent drug alterations cause such high levels of resistance to existing antibiotics. 11 Genetic transmission of resistance agents by plasmids, integrons, transposons, and other mobile genetic elements, in addition to widespread antibiotic resistance, also transforms commensal bacteria into pathogens.…”

Section: Global Concern For Mdr Xdr and Pdr Pathogensmentioning

confidence: 99%

“…1,2 Several antibacterial resistance profiles have been detected recently including the multidrug-resistant (MDR), extensively drugresistant (XDR) and pan drug-resistant (PDR) phenotypes. [3][4][5][6] Accordingly, the human health and efficiency of commonly used antibiotics are threatened seriously by MDR and XDR bacteria. Studies showed that at least 25,000 patients die each year in the European hospitals from an infection due to MDR bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…Studies showed that at least 25,000 patients die each year in the European hospitals from an infection due to MDR bacteria. [1][2][3][4][5][6] Furthermore, the mortality rate for patients infected by XDR organisms is reported to be over 50 percent, which has led to increased healthcare costs. 1,2,[4][5][6] The impacts of resistant infections to healthcare costs are estimated at about $ 20 billion yearly and they also result in 8 million additional hospital days in the United States.…”

Section: Introductionmentioning

confidence: 99%

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How Phages Overcome the Challenges of Drug Resistant Bacteria in Clinical Infections

Moghadam

Amirmozafari

Shariati

et al. 2020

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Nowadays the most important problem in the treatment of bacterial infections is the appearance of MDR (multidrug-resistant), XDR (extensively drug-resistant) and PDR (pan drug-resistant) bacteria and the scarce prospects of producing new antibiotics. There is renewed interest in revisiting the use of bacteriophage to treat bacterial infections. The practice of phage therapy, the application of phages to treat bacterial infections, has been around for approximately a century. Phage therapy relies on using lytic bacteriophages and purified phage lytic proteins for treatment and lysis of bacteria at the site of infection. Current research indicates that phage therapy has the potential to be used as an alternative to antibiotic treatments. It is noteworthy that, whether phages are used on their own or combined with antibiotics, phages are still a promising agent to replace antibiotics. So, this review focuses on an understanding of challenges of MDR, XDR, and PDR bacteria and phages mechanism for treating bacterial infections and the most recent studies on potential phages, cocktails of phages, and enzymes of lytic phages in fighting these resistant bacteria.

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“…Bahramian et al published the rst report about metallo-β-lactamase-6 (NDM-6) among K. pneumoniae in New Delhi. ST147 strains were also isolated from dialysis patients in Iran (15). Firoozeh et al reported 20 (11.1%) K. pneumoniae isolates harboring bla NDM−1 gene (16).…”

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confidence: 99%

First Report of New Delhi Metallo-β-Lactamase-1 (NDM-1) Among Escherichia Coli Strains Isolated from Leukemia Patients in Iran

Roshani¹,

Goodarzi²,

Dehbashi³

et al. 2020

Preprint

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Background: Escherichia coli has appeared as an important opportunistic pathogen responsible for nosocomial infections in Patients with immunodeficiency particularly in leukemia patients. New Delhi metallo-β-lactamase (NDM-1) is an enzyme that class of beta-lactam antibiotics and is used in treatment of multi-drug resistant (MDR) infections. Case Presentation: In this study, 80 isolates of Escherichia coli and Klebsiella pneumoniae collected over the course of two years from two medical centers of Tehran, Iran. Production of carbapenemase was detected of the isolates using MHT. New Delhi metallo-beta-lactamase 1 (blaNDM-1) genes were detected by polymerase chain reaction (PCR) ampliﬁcation with speciﬁc primers 2 blaNDM-1 producing E.coli strains were isolated from 2 leukemia of patients, The isolates were resistant to carbapenems (imipenem, meropenem),two isolates were positive for carbapenemase production by Modified Hodge test.Conclusions: The emerging of NDM-1 producing E. coli is a threat for leukemia patients in Oncology and hematology departments. We concluded that the incidence of MDR pathogens increased amang patients with leukemia and is life threatening.

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First report of New Delhi metallo-β-lactamase-6 (NDM-6) among pneumoniae ST147 strains isolated from dialysis patients in Iran

Cited by 35 publications

References 12 publications

<p>Evaluating the antimicrobial resistance patterns among major bacterial pathogens isolated from clinical specimens taken from patients in Mofid Children’s Hospital, Tehran, Iran: 2013–2018</p>

<p>Evaluating the antimicrobial resistance patterns among major bacterial pathogens isolated from clinical specimens taken from patients in Mofid Children’s Hospital, Tehran, Iran: 2013–2018</p>

<p>How Phages Overcome the Challenges of Drug Resistant Bacteria in Clinical Infections</p>

First Report of New Delhi Metallo-β-Lactamase-1 (NDM-1) Among Escherichia Coli Strains Isolated from Leukemia Patients in Iran

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