First Report of Oncological Outcome and Prognostic Analysis in a First-Line Setting of Short Hydration Gemcitabine and Cisplatin Chemotherapy for Patients with Metastatic Urothelial Carcinoma

Naiki, Taku; Nagai, Takashi; Sugiyama, Yosuke; Etani, Toshiki; Nozaki, Satoshi; Iida, Kei; Noda, Yusuke; Shimizu, Nobuhiko; Isobe, Teruki; Matsumoto, Daisuke; Kubota, Hirokazu; Hamamoto, Shuzo; Ando, Ryosuke; Kawai, Noriyasu; Yasui, Takahiro

doi:10.1159/000517326

Cited by 8 publications

(18 citation statements)

References 29 publications

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“…Table 1 shows the typical characteristics of the included studies. The articles considered were published in full-text format in the English language between 2015 and 2022 (14)(15)(16)(17)(18)(19)(20)(21). Four studies were performed in Japan (15,16,19,21), two in China (14,20), and one each in Korea (17) and Taiwan (18).…”

Section: Features Of the Included Researchmentioning

confidence: 99%

“…The articles considered were published in full-text format in the English language between 2015 and 2022 (14)(15)(16)(17)(18)(19)(20)(21). Four studies were performed in Japan (15,16,19,21), two in China (14,20), and one each in Korea (17) and Taiwan (18). The sample sizes ranged from 68 to 4,591, with a median of 319.5.…”

Section: Features Of the Included Researchmentioning

confidence: 99%

“…The sample sizes ranged from 68 to 4,591, with a median of 319.5. Four studies recruited patients with RCC (14,15,17,20), two studies enrolled patients with PCa (16,18), and two studies included patients with UC (19,21). Seven studies were retrospective studies (15)(16)(17)(18)(19)(20)(21) and one was a prospective trial (14).…”

Section: Features Of the Included Researchmentioning

confidence: 99%

“…Previous research has revealed the predictive usefulness of the GNRI in many different forms of cancer, including gastric cancer (11), hepatocellular carcinoma (9), pancreatic cancer (12), and oral squamous cell carcinoma (13). The prognostic factor of GNRI in patients with UC has been the subject of several studies with varying results (14)(15)(16)(17)(18)(19)(20)(21). We collated relevant literature and conducted this study to evaluate the correlation between prognosis and GNRI in patients.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic impact of geriatric nutritional risk index on patients with urological cancers: A meta-analysis

Ye²

2023

Front. Oncol.

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BackgroundDespite previous research examining the predictive value of the geriatric nutritional risk index (GNRI) in individuals with urological cancers (UCs), results have been conflicting. This study aimed to comprehensively explore the potential link between GNRI and the prognosis of UCs using a meta-analysis.MethodsThe Cochrane Library, PubMed, Embase, and Web of Science databases were systematically and exhaustively searched. We estimated the prognostic importance of the GNRI in patients with UCs by calculating the pooled hazard ratios (HRs) and 95% confidence intervals (CIs) on survival outcomes. Publication bias was identified using Egger’s test and Begg’s funnel plot.ResultsEight trials with 6,792 patients were included in our meta-analysis. Patients with UCs who had a lower GNRI before treatment had a higher risk of experiencing worse overall survival (HR = 2.62, 95% CI = 1.69–4.09, p < 0.001), recurrence-free survival/progression-free survival (HR = 1.77, 95% CI = 1.51–2.08, p < 0.001), and cancer-specific survival (HR = 2.32, 95% CI = 1.28–4.20, p = 0.006). Moreover, the subgroup analysis did not change the predictive significance of the GNRI in individuals with UCs. Neither Egger’s nor Begg’s test indicated substantial bias in this analysis.ConclusionAs a result of our meta-analysis, we found that a low GNRI strongly predicts poor prognosis for patients with UCs. A lower pretreatment GNRI indicates poor survival outcomes in UCs.

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Section: Features Of the Included Researchmentioning

confidence: 99%

Section: Features Of the Included Researchmentioning

confidence: 99%

Section: Features Of the Included Researchmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic impact of geriatric nutritional risk index on patients with urological cancers: A meta-analysis

Ye²

2023

Front. Oncol.

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“…Systemic inflammation, which can detrimentally affect solid tumors, is measured by assessing peripheral blood [19][20][21][22][23]. Numerous studies have identified serum biomarkers associated with oncological outcomes in patients with metastatic or localized bladder cancer receiving systemic chemotherapy [24,25] or radical treatment [26,27]. Of such prognostic markers, the modified Glasgow prognostic score (mGPS) is used to assess nutrition and is convenient and easy to use since it is based on C-reactive protein (CRP) and serum albumin (Alb) levels [28].…”

Section: Introductionmentioning

confidence: 99%

Survival Outcome after Reduced-Port Laparoscopic Radical Cystectomy for Bladder Cancer: Long-Term Follow-Up Analysis

et al. 2022

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Introduction: This study had two objectives: (i) to evaluate oncological outcomes in a long-term follow-up of patients with bladder cancer after reduced-port laparoscopic radical cystectomy (RP-LRC) and (ii) to assess the effect of modified Glasgow prognostic scores (mGPS) on patient outcomes. Methods: Consecutive patients (n = 100) who received RP-LRC between March 2012 and December 2018 at our institution and affiliated hospital were retrospectively reviewed. Preoperative serum albumin and C-reactive protein levels were determined. Patients were grouped based on clinical T stage (≤cT2: n = 75, ≥cT3: n = 25) using pooled cumulative data. Oncological outcomes and mGPS as a prognostic biomarker were analyzed retrospectively. Kaplan-Meier curves displayed recurrence and survival rates. Univariate and multivariate Cox regression analyses evaluated potential prognostic factors for recurrence-free survival (RFS) and cancer-specific survival (CSS). Results: Patient characteristics between the two groups were statistically similar for preoperative hematological and mGPS status, blood loss level, rate of allogeneic transfusion, and pneumoperitoneum time. After a median follow-up period of 55 months, 40/100 patients experienced disease relapse. RFS and CSS for ≤cT2 were significantly less than for ≥cT3 (p < 0.001, p < 0.05, respectively). Distant metastasis occurred in 30 patients with similar distributions of relapse sites between T-stage cohorts. Median RFS for mGPS 1/2 were 18.9 (95% confidence interval [CI]: 8.8–not assessed [NA]) and 35.0 (95% CI: 8.7–NA) months, respectively, significantly worse than for mGPS 0 (median NA, 95% CI: NA–NA); CSS was similar. Univariate and multivariate analyses revealed ≥cT3 stage, worse clinical N stage, and poor mGPS status were significant prognostic factors for short RFS and CSS. Conclusions: A large proportion of bladder cancer patients who undergo RP-LRC experience relapse, with ≥cT3 stage, worse clinical N stage or poor mGPS status identified as significant prognostic factors. Our findings may contribute to improved surgical procedures for such patients.

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Geriatric nutritional risk index as a prognostic marker for patients with upper tract urothelial carcinoma receiving radical nephroureterectomy

Chang

Hung

Chen

et al. 2023

Sci Rep

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To investigate the prognostic value of the geriatric nutritional risk index (GNRI) in patients with upper tract urothelial cell carcinoma (UTUC) receiving radical nephroureterectomy (RNU). Between January 2001 and December 2015, we enrolled 488 patients with UTUC underwent RNU in Taichung Veterans General Hospital. GNRI before radical surgery was calculated based on serum albumin level and body mass index. The malnutritional status was defined as GNRI < 92.0. Using Kaplan–Meier analyses and Cox proportional hazards models to analyze the risk factors on disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS). 386 patients were categorized as normal nutritional status (GNRI ≥ 92) and 102 patients as malnutritional status (GNRI < 92). We used the receiver operating characteristic (ROC) curve for determined the association between GNRI and OS, with area under the curve (AUC) being 0.69. The 5-year survival rate of DFS, CSS and OS were 48.6%, 80.5% and 80.5% in the normal nutritional group and 28.0%, 53.2% and 40% in the malnutritional group. Using the multivariate analysis, malnutritional status was found as an independent risk factor for OS (hazard ratio [HR] = 3.94, 95% confidence interval [CI] 2.70–5.74), together with age (HR = 1.04, 95% CI 1.02–1.06), surgical margin positive (HR = 1.78, 95% CI 1.13–2.82), pathological T3 (HR = 2.54, 95% CI 1.53–4.21), pathological T4 (HR = 6.75, 95% CI 3.17–14.37) and lymphovascular invasion (HR = 1.81, 95% CI 1.16–2.81). We also found GNRI index as independent risk factor in DFS (HR = 1.90, 95% CI 1.42–2.54) and CSS (HR = 5.42, 95% CI 3.24–9.06). Preoperative malnutritional status with low GNRI is an independent marker in predicting DFS, CSS and OS in UTUC patients underwent RNU.

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First Report of Oncological Outcome and Prognostic Analysis in a First-Line Setting of Short Hydration Gemcitabine and Cisplatin Chemotherapy for Patients with Metastatic Urothelial Carcinoma

Cited by 8 publications

References 29 publications

Prognostic impact of geriatric nutritional risk index on patients with urological cancers: A meta-analysis

Prognostic impact of geriatric nutritional risk index on patients with urological cancers: A meta-analysis

Survival Outcome after Reduced-Port Laparoscopic Radical Cystectomy for Bladder Cancer: Long-Term Follow-Up Analysis

Geriatric nutritional risk index as a prognostic marker for patients with upper tract urothelial carcinoma receiving radical nephroureterectomy

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