First report of OXA-181 and NDM-1 from a clinical Klebsiella pneumoniae isolate from Nigeria

Uwaezuoke, Nkolika Stella; Kieffer, Nicolas; Iregbu, Kenneth; Nordmann, Patrice

doi:10.1016/j.ijid.2017.05.004

Cited by 19 publications

(14 citation statements)

References 10 publications

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“…Recent studies have remarked the emergence of K. pneumoniae and other Enterobacteriaceae producing both carbapenemases from Turkey and some other countries. 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 For that, our result was found to be significant in terms of the reliability of RESIST-3 O.K.N. K-SeT in detecting NDM and OXA-48 co-producers.…”

Section: Discussionsupporting

confidence: 49%

“… 31 , 32 , 33 , 34 , 35 Moreover the detection of CR Kp isolates harboring NDM together with OXA-48 was considered as a premonitory outcome of the study because it shows the spread of CR Kp NDM and OXA-48 co-producers. 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 On the other hand, this report has been the third one from Turkey presenting the isolation of KPC producing K. pneumoniae , so far. 41 , 42 Kuskucu et al also isolated KPC enzymes in two E. coli isolates in Turkey.…”

Section: Discussionmentioning

confidence: 71%

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Performance of “RESIST-3 O.K.N. K-SeT” immunochromatographic assay for the detection of OXA-48 like, KPC, and NDM carbapenemases in Klebsiella pneumoniae in Turkey

Sağıroğlu

Hasdemir

Gelmez

et al. 2018

Brazilian Journal of Microbiology

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In this study, the performance of the “RESIST-3 O.K.N. K-SeT” (Coris BioConcept, Gembloux, Belgium) immunochromatographic assay was evaluated in 132 Klebsiella pneumoniae comprising 102 carbapenem resistant and 30 carbapenem susceptible isolates. Genotypically known isolates of Gram negative bacteria (n = 22) including various species were also tested by the assay as controls. The isolates tested by the immunochromatographic assay and also were run PCR for blaKPC, blaIMP, blaVIM, blaNDM, and blaOXA-48. The rates of blaNDM, blaOXA-48, and blaKPC in carbapenem resistant isolates were found at 52.9%, 39.2%, and 2.0%, respectively. Both blaNDM and blaOXA-48 were found in six (5.9%) isolates. The results of the assay showed 100% concordance with those obtained by PCR in 132 K. pneumoniae. The agreement between the two methods was found to be identical at the isolate level. The assay also correctly detected all genotypically known isolates of Escherichia coli, Serratia marcescens, Citrobacter freundii, Enterobacter cloacae, K. pneumoniae carrying blaKPC, blaNDM, and/or blaOXA-48. On the other hand, the assay did not exhibit any cross-reaction in control isolates harboring blaIMP and blaVIM. We conclude that the RESIST-3 O.K.N. K-SeT is a reliable, rapid, and user friendly test and we recommend it for routine diagnostic laboratories.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 71%

Performance of “RESIST-3 O.K.N. K-SeT” immunochromatographic assay for the detection of OXA-48 like, KPC, and NDM carbapenemases in Klebsiella pneumoniae in Turkey

Sağıroğlu

Hasdemir

Gelmez

et al. 2018

Brazilian Journal of Microbiology

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“…Nonetheless, OXA-48-like and NDM-like enzymes seem to be the main carbapenemases identified in this continent (4), with the exception of South Africa, where NDM and KPC producers have additionally been found (9,10). Isolates producing OXA-48-like enzymes seem to be predominant in the Northern part of the continent (4,10), and strains producing OXA-181 are widespread in South Africa, Nigeria, and Angola (11)(12)(13). All of those areas are in mainland Africa and have connections to many other countries, which may explain the recurrent importations and spread of those resistance determinants.…”

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confidence: 92%

Screening and Characterization of Multidrug-Resistant Gram-Negative Bacteria from a Remote African Area, São Tomé and Príncipe

Poirel

Aires-de-Sousa

Kudyba

et al. 2018

Antimicrob Agents Chemother

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The occurrence of resistance to last-resort antibiotics was evaluated among isolates recovered from hospitalized children in a remote African archipelago, São Tomé and Príncipe, where there is limited access to those antibiotics. Fifty patients were screened for colonization by carbapenem-, pan-aminoglycoside-, or polymyxin-resistant A total of 36 isolates (including 30 and 4) were recovered from 23 patients, including 26 isolates harboring the carbapenemase gene, a single isolate harboring the 16S rRNA methylase gene encoding pan-resistance to aminoglycosides, and 8 isolates coharboring both genes. A single isolate possessed the plasmid-borne colistin resistance gene A high clonal relationship was found for OXA-181-producing (4 clones), and conversely, three of the four OXA-181-producing isolates were clonally unrelated. This study overall showed a high prevalence of resistance to last-resort antibiotics in this country, where no epidemiological data were previously available.

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“…5,6 The gene encoding OXA-181, bla OXA-181 , is often found to be located on plasmids of incompatibility group (Inc) X that are defined as X3 type (IncX3). [7][8][9] These plasmids are known to disseminate various carbapenemase genes, including bla KPC and bla NDM . 10,11 To date, only two OXA-181-producing E. coli isolates have been reported in China, namely, in Sichuan and Henan.…”

Section: Introductionmentioning

confidence: 99%

<p>First Report of OXA-181-Producing <em>Klebsiella pneumoniae</em> in China</p>

Liu

Fang

Zeng

et al. 2020

IDR

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We present here the first report of an OXA-181-producing Klebsiella pneumoniae isolated from the fecal specimen of a patient in China. The OXA-181-encoding gene bla OXA-181 was located on a 51 kb IncX3-type plasmid. Conjugation assay and wholegenome sequencing analysis revealed that this transferrable plasmid in the K. pneumoniae isolate might have originated from Escherichia coli and have the potential to mediate the spread of bla OXA-181 .

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First report of OXA-181 and NDM-1 from a clinical Klebsiella pneumoniae isolate from Nigeria

Cited by 19 publications

References 10 publications

Performance of “RESIST-3 O.K.N. K-SeT” immunochromatographic assay for the detection of OXA-48 like, KPC, and NDM carbapenemases in Klebsiella pneumoniae in Turkey

Performance of “RESIST-3 O.K.N. K-SeT” immunochromatographic assay for the detection of OXA-48 like, KPC, and NDM carbapenemases in Klebsiella pneumoniae in Turkey

Screening and Characterization of Multidrug-Resistant Gram-Negative Bacteria from a Remote African Area, São Tomé and Príncipe

<p>First Report of OXA-181-Producing <em>Klebsiella pneumoniae</em> in China</p>

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