First Report of Whole-Genome Sequence of Colistin-Resistant <i>Klebsiella quasipneumoniae</i> subsp. <i>similipneumoniae</i> Producing KPC-9 in India

Shankar, Chaitra; Karunasree, Susmitha; Manesh, Abi; Veeraraghavan, Balaji

doi:10.1089/mdr.2018.0116

Cited by 10 publications

(1 citation statement)

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“…similipneumoniae was described in India. 28 The characteristics of hm/hv in MDR and non-MDR K. quasipneumoniae subsp. similipneumoniae have already been reported; however, not in the same strain, as described in this study (i.e., MDR-hm/ hv K. quasipneumoniae subsp.…”

Section: Resultsmentioning

confidence: 99%

Genomic Characterization of a Multidrug-Resistant and Hypermucoviscous/Hypervirulent Klebsiella quasipneumoniae subsp. similipneumoniae ST4417 Isolated from a Sewage Treatment Plant

Furlan

Gallo

Campos

et al. 2020

Microbial Drug Resistance

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Clinical strains of Klebsiella quasipneumoniae subsp. similipneumoniae have been reported worldwide. Multidrug-resistant (MDR) hypermucoviscous (hm)/hypervirulent (hv) lineages have become a global problem for public health worldwide. Therefore, this study aimed to characterize by whole-genome sequencing a MDRhm/hv K. quasipneumoniae subsp. similipneumoniae SWT10 strain belonging to the new sequence type ST4417 isolated from a sewage treatment plant. Results: The SWT10 strain was recovered from a sewage treatment plant in Brazil and presented the hm and MDR phenotypes. Resistome analysis showed antimicrobial resistance genes associated with resistance to fluoroquinolones, b-lactams, tetracyclines, trimethoprim, aminoglycosides, sulfonamides, macrolides, and fosfomycin as well as several heavy metal resistance genes. Virulome analysis showed virulence factors related to hv lineages. Multilocus sequence typing analysis revealed the new ST4417, which was grouped in CC1584 by the minimum-spanning tree. Besides, five plasmid incompatibility groups, two prophage-related sequences, and 66 genomic islands were detected. Conclusion: This study reports for the first time the genome sequence of a MDR-hm/hv K. quasipneumoniae subsp. similipneumoniae recovered from the environment, which contributes to a better understanding about these lineages as well as for surveillance studies worldwide.

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Section: Resultsmentioning

confidence: 99%